From: chemistry-request at ccl.net <br />
To: chemistry-request at ccl.net<br />
Date: Fri Sep 15 08:15:25 2023<br />
Subject: 23.10.12 <span class="fancysmall">Identifying leads with targeted selectivity through virtual screening, Online Webinar</span><br />

<pre>Identifying leads with targeted selectivity through virtual screening - 
optimizing the starting point to predict the molecules most likely to succeed

Register here - <a href="https://www.cresset-group.com/about/events/identifying-leads/" target="_blank">https://www.cresset-group.com/about/events/identifying-leads/</a>

Cannabinoid (CB) receptors selectivity is an active area of research interest 
for several therapeutic reasons. The limited pool of potent analgesics 
has resulted in widespread use of opioid analgesics, causing rising cases of 
opioid addiction in the US. Targeting CB2 selectively has the potential 
to introduce a potent analgesic, without the psychoactive effects of CB1 binding, 
potentially reducing the usage of opioid based analgesics.

Virtual screening can be a great first step in designing receptor subtype-specific 
ligands and can be performed using protein-ligand structural data.
We demonstrate how, by applying ligand-based computational methods 
combined with knowledge of structural biology and chemistry, we can define a novel 
ligand starting point prior to carrying out a virtual screen, resulting in hits 
with better receptor subtype selectivity.

Date: Thursday 12th October, 2023
Time: 2pm BST / 3pm CEST / 9am EDT / 6:30pm IST
Duration: 45 minutes
Format: Webinar

Register Here - <a href="https://www.cresset-group.com/about/events/identifying-leads/" target="_blank">https://www.cresset-group.com/about/events/identifying-leads/</a></pre>
<b>NOTE THAT E-MAIL ADDRESSES HAVE BEEN MODIFIED!!!</b><br />
All @ signs were changed to {=} to fight spam. Before you send e-mail, you
need to change {=} to @<br />
For example: change joe{=}big123comp.com to joe@big123comp.com<br />
<em>Please let colleagues know about conference listingts at
Computational Chemistry List Conference Page at</em>
<a href="http://www.ccl.net/chemistry/a/conferences/"
class="link">http://www.ccl.net/chemistry/a/conferences/</a>.