PostDoctoral Fellow

At GlaxoSmithKline, scientists in Research and Development are committed 
to capturing this moment. They bring to it their own very considerable 
abilities, the resources of a parent company devoted to the scientific 
enterprise, and the urgency of knowing that their highest purpose is the 
relief of human suffering. In pursuit of this purpose, they desire to make 
of GlaxoSmithKline a magnet for others who share their talents, whether as
prospective corporate colleagues or as collaborators in industry, academe,
and government.

GlaxoSmithKline is dedicated to an innovative workplace and supports you 
with career long opportunities and learning.We offer a competitive benefits
and compensation package designed to attract and retain the very best.

Basic Qualifications  PhD or equivalent experience in computational 
chemistry and will have relevant skills and competencies enabling you 
to perform in a high level computational chemistry research environment. 
You will have a thorough understanding and practical expertise of 
computational chemistry methods, including protein structure-based 
and small-molecule modelling techniques together with data analysis.
Good written and oral communication skills and the ability to work as part
of multi-disciplinary teams are also a requirement for this role. 
   
  
Preferred Qualifications The following competencies would be an 
advantage.
Practical experience supporting of medicinal chemistry projects
Structure-based design
Small-molecule modelling, ligand-based design
Data analysis techniques
   

Details GlaxoSmithKline (GSK) is a world leading research-based 
pharmaceutical company that combines both individual talent and 
technical resources to create a platform for the delivery for strong 
growth in a rapidly changing healthcare market. Our mission is to improve 
the quality of human life by enabling people to do more, feel better and 
live longer. 

As part of a new project to identify and develop a novel class of 
antibacterials targeting gram negative pathogens, a postdoctoral 
position in computational chemistry has been created within our 
Computational and Structural Chemistry department to work with 
the chemists, biologists and structural scientists on the team. 
You will apply a variety of computational techniques to design molecules 
and arrays, often taking multiple factors into account such as potency, 
selectivity and ADMET (Absorption, Distribution, Metabolism, Elimination, 
Toxicity) properties. The analysis of SAR data and the interpretation of 
results are also important aspects of the role together with the full 
exploitation of highly novel emerging protein structural information 
from our protein crystallography group. This position will be based at 
our Upper Providence, PA site. However, as part of a large transnational 
team it is also anticipated that the position will provide you with the 
opportunity to spend a small percentage of time working at our Stevenage, 
UK site.

In this role you will provide computational chemistry support for gram 
negative drug discovery activities. Working with the project team, you 
will design and optimize ligands to deliver candidate molecules. 
You will be expected to use ligand-based and structure-based design 
techniques for the identification of hits and their optimisation, and 
ensure that ADMET properties are incorporated into the design of molecules.
In addition, you may assist in the construction of focused screening sets,
the acquisition of compounds, library design and de novo template design.
Another aspect of this role will be the analysis of data from SAR and 
high-throughput screens. You will be expected to report computational 
results in a timely manner, in a format suitable for comprehension by 
business partners, and to work collaboratively with scientists from a 
variety of disciplines to achieve these objectives. 
In addition to these compound design activities, in this role you will 
also have the opportunity to develop novel computational methodologies 
to address design goals of the project team.

We offer a competitive total compensation package as well as an 
environment conducive to personal and professional growth.
No agency referrals please.
Developing talent through equality of opportunity, M/F/D/V.
For confidential consideration and efficient processing, please 
apply online at: www.gsk.com requisition number #49732