Job description  	

We are seeking an expert in the field chemical/protein structure 
information analysis and management. You will be responsible for 
transforming our efforts in cheminformatics by providing innovative 
links to our clinical and molecular data analysis efforts. 
Working closely with members of our in silico Discovery team you 
will be responsible for applying novel approaches to the analysis 
and organization of large and complex datasets, particularly directed 
towards the fields of alternative medical use and combinatorial 
therapy prediction.


Profile 	

The applicant must be knowledgeable and experienced in a variety of 
current chemistry and structural biology resources. Specifically, 
the successful candidate will be adept in a diversity of computational 
chemistry pursuits, such as molecular modelling (e.g. protein-ligand 
interactions) structure-based drug design and/or in silico screening. 
You will furthermore be responsible for managing the integration of 
chemical content and biological structure information with our 
existing bioinformatics infrastructure. Experience with bioinformatics 
tools a clear benefit.

 

Responsibilities:

The suitable candidate will be responsible for ->

* leading and innovating our efforts in the chemical biology domain

* the application and customization of computational chemistry 
approaches to a variety of clinically/biologically focused discovery 
pursuits.

* developing strategies and processing workflows for chemistry 
database integration efforts and in silico discovery processes

* integrating chemical and structural content from reference 
databases into a modular life science informatics platform;

 
Demands 	

The successful candidate must be a team player with the following attributes:

* min. 4-yrs cheminformatics/structural biology/chemical biology experience;

* Experience with a wide array of data formats employed to depict chemistry 
information (MOL/SDF/RDF, PubChem XML, CML, PDB, MIF, InChI/SMILES);

* Experience in one or more of molecular modeling, structure-based drug 
design and/or in silico screening - FLEXX

* Experience with toolkits commonly employed to capture, index and/or 
manipulate chemistry data (MDL/Isentris, JChem/MarvinBeans, OpenBabel, MOE);

* Experience developing and optimizing database driven applications;

* Experience with chemical/protein structure visualization tools 
(MDL/Chime, Cn3D, MarvinView, KegDraw)

* Experience with chemical structure databases (CAS, PubChem,
Crossfire Beilstein);

* Sound understanding of organic/medicinal chemistry and familiarity 
with concepts from molecular biology and bioinformatics.



ABOUT LIFE Biosystems: 

LIFE Biosystems is working at the forefront of a new Era in molecular 
medicine. Developing and applying innovative new approaches to the 
in silico analysis of clinical and molecular information, we explore 
the boundaries of knowledge surrounding targeted therapeutic intervention. 
Our commitment to patient benefit is reflected in all that we do: 
we are a company driven by the knowledge that our discovery approaches 
can make a difference. With human disease providing a formidable 
molecular foe, we are seeking individuals who can demonstrate 
the innovation, creativity and knowledge to help us tip the balance 
in patients favour. In return, we offer prospective employees exciting 
challenges, unique opportunities for career growth, and a fast-paced 
scientific environment that emphasizes innovation and achievement.

To apply, please submit a short Curriculim Vitae to:

Dr. David Jackson
LIFE Biosystems GmbH
Poststr. 34
D-69115 Heidelberg
Germany

or email it to: careers(at)lifebiosystems.com