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To: jobs at ccl.net
Date: Fri May 14 10:47:20 2010
Subject: 10.05.14 Cheminformatics Research Associate
Job Summary:
The Center for Molecular Innovation and Drug Discovery (CMIDD) at
Northwestern University near Chicago, IL has an immediate opening for a
Cheminformatics Specialist. This research position is responsible for the
operation and maintenance of computational workflows supporting
multi-investigator small molecule drug discovery, with an emphasis on the
hit-to-lead stage. 
Primary workflows managed will include ones for compound and data
management, search, and analysis; compound property and diversity analysis;
virtual library enumeration and synthetic set design; bioisosteric
elaboration; and pharmacophore and lead-hopping methods.

Specific Responsibilities:
- Oversees daily operation of cheminformatics tasks and workflows in
  support of a multiple-investigator industrialized academic
  hit-to-lead/hit-to-probe drug discovery center.

- Operates, maintains, and develops PC- and server-based computational
  capabilities related to the hit-to-lead stage, as well as general lead
  and probe discovery efforts.

- Integrates data input/output between workflow components and between
  workflows and users.

- Participates in developing cheminformatics operations in response to
  changing Center needs, including development of the informatics
  associated with a first-stage compound storage plan.

Minimum Qualifications:
- A Ph.D. in Chemistry with relevant experience in small molecule
  cheminformatics, or a Ph.D. in Cheminformatics with experience in modern
  medicinal chemistry.

- At least one year of postdoctoral or professional experience related to
  this position with evidence of productivity (publications or patents).

- Experience with developing and maintaining cross-OS server- and PC-based
  advanced small molecule cheminformatic workflows and molecular modeling
  applications.
- Experience with specific cheminformatic packages including Pipeline Pilot
  and OpenEye.

- Track record of successful work in a modern research enterprise.

- English fluency and excellent team, oral and written communication and
  reporting skills.

Preferred Qualifications:
- Two or more years of productive experience in a professional and
  technologically advanced work environment, with practical pharma
  experience most beneficial.

- Experience with advanced Pipeline Pilot-based HTS followup, and virtual
  library and fragment/structure-based drug discovery computational
  workflows.

- Unix-level operational ability, broad familiarity with practical small
  molecule computational tools (Accelrys, Tripos, CCG, MolNetworks, etc.),
  and ability to integrate selected tools via scripting.

- Experience integrating small molecule and macromolecule representation
  and computation, including molecular modeling and virtual screening (e.g.
  Pymol, COOT, GRASP, GOLD, etc.).

- Other advanced CAMD/CADD experience in a pharmaceutical context, and
  practical operational experience supporting multi-user computational
  needs.
Submit application through Northwestern University's Job website 
http://www.northwestern.edu/hr/jobs/
Job ID:  15917, Job Title: Research Associate
Must include salary requirement and contact information for 3 references.
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Modified: Sat May 15 04:14:24 2010 GMT
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