Applications are invited for a Postdoc position and a Wissenschaftliche
Hilfskraft (PhD student) position immediately available in the
Computational Pharmaceutical Chemistry & Molecular Bioinformatics group
(Prof. Dr. Holger Gohlke) at the Heinrich-Heine-University, Duesseldorf,
Germany.

* Postdoc position: In this project, the applicability of free energy methods
for lead optimization shall be evaluated in collaboration with an industrial
partner. Two methods shall be tested, thermodynamic integration (TI), a free 
energy pathway method, and MM/PBSA, an end-point method. These methods shall 
be applied to datasets of ligands from previous lead optimization phases. 
Ideal candidates would have a strong background in computational or 
theoretical chemistry, biochemistry, structural biology. Experience in 
molecular modeling and simulation of biological systems, preferentially with 
the AMBER package, structure-based drug design, advanced programming skills 
(Perl, Python), and familiarity with the UNIX/Linux operating system is 
highly desirable.

* Wissenschaftliche Hilfskraft (PhD student) position: Applications are invited
for a Wissenschaftliche Hilfskraft position starting immediately. The 
initial appointment will be for one year with reappointment to a PhD student 
position afterwards by mutual agreement. The research topic of the PhD 
thesis will originate from one of the areas described here: 
http://cpclab.uni-duesseldorf.de/research .
Ideal candidates would have a strong background in pharmaceutical sciences,
chemistry, or biochemistry. A good command of the German tongue is 
mandatory. Experience in molecular modeling and simulation of biological 
systems, programming skills (C, Perl, Python), familiarity with the 
UNIX/Linux operating system, and an interest in developing new 
methodologies is highly desirable.

Detailed information about living and studying in Duesseldorf is provided 
here: http://www.uni-duesseldorf.de/home/Fakultaeten/math_nat/Graduiertenkollegs/biostruct/Application/duesseldorf

Applicants should submit applications (a current CV, description of 
scientific experience and interests, and contact data of three references) 
by email to gohlke|a|uni-duesseldorf.de .