CNIBR is a world class fully integrated drug discovery center of 
excellence committed to discovering and developing innovative therapies. 
This newly established Novartis R&D center is dedicated to discovering 
innovative medicine for treating cancer, viral infection, and other 
diseases that are prevalent in China and Asia countries.

Job Description 


We have a career opportunity within our organization for the following 
position of CHEMINFORMATICS 

The successful candidate will employ cheminformatics in support of drug 
discovery projects and will work in close collaboration with 
multidisciplinary drug discovery teams (Chemistry, Biology, HTS, etc.). 
The candidate will suggest and develop new approaches leading to the 
identification of novel hit and lead molecules through the mining
of screening campaign databases and published literature. 
It will also design and maintain a cutting-edge Cheminformatics 
platform of relevant resources both in terms of software, chemical 
database and scientific information which will be actively used by the 
project. 

Qualifications:

Candidates should at least possess a Ph.D. degree / Post doc (or 
equivalent) in computational chemistry, computational biology or a 
relevant field with at least two year industry experiences, preferably 
with up-to-date biological screening paradigms. Candidates should 
possess an in-depth knowledge and comprehension of cheminformatics 
in drug discovery, especially on the stage of hit-to-lead, e.g., 
virtual screening.

o A Proven track record in the use of standard cheminformatics approaches 
(e.g., PCA analysis, Support-Vector Machine and Recursive Partitioning) 
and cheminformatics software (e.g., PipelinePilot, Spotfire, 
physico-chemical prediction algorithms) and use of standard and 
comprehensive statistical analysis/methods. 

o Demonstrate skills in the fields of molecular descriptors (knowledge of 
existing fragment counts, pharmacophore fingerprints and design of new 
terms), and structure-activity relationships. Demonstrated expertise in 
handling/maintenance of large databases, clustering, QSAR, and virtual 
library design.

o Experienced in protein modeling, structural analysis and docking. 
A good understanding of bioinformatics to enhance target knowledge (e.g., 
biological pathways, gene expression data, etc.)

o Background on medicinal chemistry and basic knowledge of synthetic 
organic chemistry.

o  Strong programming skills in two or more of the following: C, C++, 
Perl, Python, UNIX shell scripting.

o Self-motivated, proactive and a team player. Excellent written and 
oral communication skills.

Please apply online by visiting our website www.novartis.com/careers and 
search for Job ID 62975BR. You can find more openings by quoting 
NIBR Shanghai as the keyword.