10.07.15 Group Leader, Computational Chemistry

Group Leader, Computational Chemistry

Dart NeuroScience LLC (DNS) is a privately held Texas Limited Liability Company headquartered in Dallas TX with its research facility in San Diego CA. DNS will discover new technologies and develop new therapies to help maintain cognitive vitality throughout life. DNSs Scientific Computing department focuses on (i) general IT infrastructure to support company research and administration, (ii) design and implementation of bioinformatic tools, (iii) workflow and inventory management for chemistry, compound management and general research (including robotics and automation), (iv) computational modeling of small molecule-protein interactions, virtual library enumeration and screening.

The Group Leader of Computational Chemistry will have broad hands-on experience in computational chemistry with proven success using computer-aided drug design, molecular docking and dynamics, pharmacophore generation, ligand based drug design, QSAR, ADMET prediction, and cheminformatics. Familiarity with drug discovery, medicinal and combinatorial chemistry, and relevant biological disciplines (e.g. biochemistry, molecular biology, pharmacology) is required, along with the ability to integrate with these disciplines to design new bioactive compounds. The successful candidate will have expertise with a variety of modeling packages, machine learning, and programming/scripting experience to contribute to the development of computational chemistry infrastructure, lead identification and lead optimization. An ability to plan, prioritize and execute experiments in an efficient and time-effective manner with a proven track record of successfully completing projects is required. Self-starting abilities are expected. Experience with CNS targets is preferred. Additional responsibilities may include development and implementation of innovative methods and algorithms to enhance computational approaches in areas including virtual screening, library design, and cheminformatics. Contributions to the intellectual property of projects are anticipated. Viable candidates require strong written and verbal communication skills, good problem solving abilities and an ability to work effectively with a diverse team of co-workers.

Requirements:

1. A PhD chemist with 7+ years

2. Demonstrated experience with molecular modeling, computational chemistry, cheminformatics, QSAR and ADMET modeling.

3. Ability to work independently and ability to interact with a multidisciplinary team of medicinal chemists, biologists, pharmacologists and external collaborators.

4. Supervision of additional computational chemists and contractors.

5. Ability to evaluate intangible variables, requiring regular use of ingenuity and creativity.

6. Ability to contribute to scientific literature and conferences through publication and presentation of research results.

7. Experience with the generation of chemistry patent applications.

DNS offers competitive salaries and a great benefits package including incentive bonuses, healthcare, vision, dental, long-term disability, life insurance and a 401(k) retirement savings plan.

Interested individuals should send a cover letter, curriculum vitae, a brief summary of research experience and accomplishments, research interests and goals and list of publications to Dr. Tim Tully, CSO, at the address below or to ttully#dartneuroscience.com.

Alternatively you can also apply directly on our web site at http://www.dartneuroscience.com/cgi-bin/main.pl?section=Careers;page=Current_jobs.

PDF files are encouraged.