|CCL 17.07.13 PhD fellowship in computational protein and drug design (KU Leuven, Belgium)|
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To: jobs at ccl.net
Date: Thu Jul 13 09:15:02 2017
Subject: 17.07.13 PhD fellowship in computational protein and drug design (KU Leuven, Belgium)
For the Biochemistry, Molecular and Structural Biology Section of the University of Leuven (Belgium) we are looking for a highly motivated doctoral researcher who will perform scientific research and contribute to didactic tasks within the division. The laboratory of biomolecular modelling and design has an expertise in biomolecular modelling, structural bioinformatics as well as experimental biophysics and protein crystallography. Our focus is on the rational design of of novel bio-active molecules such as drugs (including protein protein interaction targets and nuclear receptors) or novel proteins (with applications ranging from catalysis to bionanotechnology and biopharmaceuticals) via computational and experimental methods. In this proposal we are currently looking to redesign nuclear receptors, a common drug target for a variety of diseases, to bind a novel ligand in order to establish an orthogonal signalling pathway for synthetic biology applications but also to understand the mechanism of these class of receptors which may help to identify novel therapeutic strategies. While this project is mainly computational, there will be also some experimental work involved. In this project we are currently looking to redesign nuclear receptors, a common drug target for a variety of diseases, to bind a novel ligand in order to establish an orthogonal signalling pathway for synthetic biology applications but also to understand the mechanism of these class of receptors which may help to identify novel therapeutic strategies. In this project, you will mainly apply computational methods (molecular dynamics, computational protein design relying on the Rosetta protein modelling suite, computational drug design methods, pharmacophore modelling and chemo-informatics). There will be also some experimental work involved at our collaborators experimental laboratory. Profile You have a masters degree in Bio-Engineering, Biology, Biochemistry, Biomedical or Pharmaceutical sciences with a passion for scientific research, in particular computational protein and drug design as well as structural biology. Experiences in this field is an asset. You have experiences with Linux, Python and/or R. You are proficient in English, both speaking and writing. You are a team-player but can also work independently, and take initiative. You are prepared and motivate to learn novel computational and experimental methods, and stay up to date with literature. You are capable to successfully complete the doctoral training and research under supervision of an advisor. We offer a fulltime scholarship (salary) tentatively starting in October 2017. After a positive evaluation the first year, the fellowship will be extended to a total of 4 years, leading to a doctoral thesis.
please contact the group leader : arnout.voet_-_kuleuven.be or utilise the online application: https://icts.kuleuven.be/apps/jobsite/vacatures/54249555?lang=enNOTE THAT E-MAIL ADDRESSES HAVE BEEN MODIFIED!!!
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