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CCL 17.10.17 Postdoctoral position in Computational Drug Design | ||||||||||||
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From: jobs at ccl.net (do not send your application there!!!) To: jobs at ccl.net Date: Tue Oct 17 11:52:28 2017 Subject: 17.10.17 Postdoctoral position in Computational Drug Design This position is a joint appointment with a nonprofit, mission focused research institute, The Baruch S. Blumberg Institute (BSBI), and an emerging computational chemistry company, Conifer Point Pharmaceuticals (Conifer). About US The Baruch S. Blumberg Institute is an independent, nonprofit research institute established in 2003 by the Hepatitis B Foundation to conduct discovery research and nurture translational biotechnology around common research themes such as chronic hepatitis, liver disease, and liver cancer in an environment conducive to interaction, collaboration and focus. It was renamed in 2013 to honor Baruch S. Blumberg, who won the Nobel Prize for his discovery of the hepatitis B virus and co-founded the Hepatitis B Foundation. www.blumberginstitute.org The mission of Conifer is to be the premier provider of web-based, drug design tools so that researchers can access rigorous molecular modeling in user friendly format. To do this, the team at Conifer Point has made several key scientific breakthroughs in recent years in the field of fragment-based drug design that promise to have a transformative impact on the discovery of drugs. To make these innovations broadly available, we have developed a prototype Cloud-hosted Web application for chemical modeling and drug discovery including fragment-based design software that is unavailable in any other commercial software package. Other industry standard methodologies (energy minimization, docking) are also included. A computational platform arising from our efforts will be a first-in-class molecular design application that is delivered via a browser with fragment searches being run in the Cloud (Amazon Web Services). www.coniferpoint.com BSBI and Conifer are located in a 112,000 ft2 facility known as the Pennsylvania Biotechnology Center (PA Biotech Center) in Doylestown, PA. The Center is a nonprofit business incubator, funded in part by a grant from the Commonwealth of Pennsylvania, whose mission is to nurture entrepreneurship and biotechnology in the region. It is home to nearly 40 research and biotechnology companies and two non-profits, the Blumberg Institute and the Hepatitis B Foundation. The facility provides a shared infrastructure and a collaborative intellectual community allowing for synergistic operations of the companies. www.pabiotechbc.org. Project The Modeling and Informatics group is seeking a creative, self-motivated computational chemist with exceptional interpersonal and problem-solving skills to join our scientific team in Doylestown, PA. The successful candidate will be responsible for the design and optimization of novel drug candidates using advanced computational techniques, including ligand- and structure-based methods. The applicant will apply computation to develop understanding of drug resistance and mutation. In addition to participating in the support of medicinal chemistry programs, the applicant will be expected to continue research in new areas of molecular modeling relevant to the drug discovery and development process. Qualifications Education: Ph.D. (or expected in next 3 months) in chemistry, biochemistry, biophysics or chemical biology with a computational emphasis Required: Fluency in English and experience in writing scientific papers Evidence of creative application of computational approaches to problems of pharmaceutical interest Evidence of integration of chemical biology, target or SAR knowledge into computational design Track record of publications, posters, and speaking engagements Experience in modern molecular modeling techniques (docking, molecular simulation, homology modeling, pharmacophore modeling, quantum mechanics, QSAR, ligand- and structure-based design) Experience with The Schrodinger Drug Discovery Suite, PyMOL Experience in scientific programming (C++, Javascript, Perl, Python) Stipend levels follow NIH guidelines. To apply please email a cover letter describing scientific background and detailed interest in this appointment and a CV with a complete list of publications to john.kulp#%#bblumberg.org or john.kulp#%#coniferpoint.comNOTE THAT E-MAIL ADDRESSES HAVE BEEN MODIFIED!!! All @ signs were changed to #%# to fight spam. Before you send e-mail, you need to change #%# to @ For example: change joe#%#big123comp.com to joe@big123comp.com Please let your prospective employer know that you learned about the job from the Computational Chemistry List Job Listing at http://www.ccl.net/jobs. If you are not interested in this particular position yourself, pass it to someone who might be -- some day they may return the favor. |
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