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Date: Wed Feb 28 09:12:38 2018
Subject: 18.02.28 Principal Computational Chemist - Drug Discovery Unit
Principal Computational Chemist

	Starting salary from: 35,800- 61,400 (GBP) per annum (dependent upon experience) 
	Job Ref: MI/18/08 
	Duration: Fixed term until 31 March 2019 (in the first instance)

About the role:
As part of the expansion of the CRUK Manchester Institute Drug Discovery Unit
we are seeking enthusiastic and proactive experts in Structure Guided
Drug Design to help drive our programmes from early lead identification
through to candidate selection.  An expert in the use of packages such
as the Schrodinger Suite, MOE, Pipeline Pilot and Cresset to drive lead
generation and lead optimisation activities, you will work closely with
our synthetic and medicinal chemists, applying both our
industry-standard tools and your own expertise to help guide and focus
chemistry strategy across our project portfolio, from hit identification
to pre-clinical candidate selection.  You will also have significant
impact in the identification, assessment and prioritisation our future
drug discovery opportunities.
Alongside these project roles, you will influence and develop our group
capabilities and collaborations in structure-guided drug design,
structural biology and chemoinformatics and seek innovative ways of
interacting with our chemistry team to maximise the use of computation
techniques in the delivery of human drug candidates.  You will also have
responsibility for the on-going support and future enrichment of our
Dotmatics informatics platform across all drug discovery disciplines.

About you:
The successful applicant should have a PhD in Chemistry or a related
subject along with extensive experience in structure-guided drug design,
computational lead generation campaigns and interactions with chemists
at different stages of drug discovery programmes.  

Why choose Cancer Research UK Manchester Institute?
The Cancer Research UK Manchester Institute (,
an Institute of The University of Manchester (, is
a world-leading centre for excellence in cancer research.  The Institute
is core funded by Cancer Research UK (, the
largest independent cancer research organisation in the world.  We are
currently situated at the internationally-renowned life sciences campus
at Alderley Park in Cheshire England, 15 miles from Manchester, a
vibrant and dynamic city surrounded by beautiful countryside

We are partnered with The Christie NHS Foundation Trust (adjacent to the
CRUK MI Paterson Building) in South Manchester (,
one of the largest cancer treatment centres in Europe.  These factors
combine to provide an exceptional environment in which to pursue basic,
translational and clinical research programmes.
For any informal enquiries about these posts, please contact Dr Allan
Jordan via email: 
The deadline for receipt of applications is: 29 March 2018.
How to apply?
To apply for this position please visit our website:
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