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Up Directory CCL 18.04.04 PostDoc in Cheminformatics; AstraZeneca, Gothenburg, Sweden
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Date: Wed Apr 4 11:09:34 2018
Subject: 18.04.04 PostDoc in Cheminformatics; AstraZeneca, Gothenburg, Sweden
Accurate permeability prediction for New Modalities compounds using
novel 3D physics-based descriptors

Were currently looking for talented scientists to join our innovative 
academic-style Postdoc. From our centre in Gothenburg, youll be in a 
global pharmaceutical environment, contributing to live projects right 
from the start. Youll take part in a comprehensive training programme, 
including a focus on drug discovery and development, given access to our 
existing Postdoctoral research, and encouraged to pursue your own 
independent research in cutting edge laboratories. Its a newly expanding 
programme spanning a range of therapeutic areas across a wide range of 
Whats more, youll have the support of a leading academic advisor, 
wholl provide you with the guidance and knowledge you need to develop 
your career. This is an exciting area that hasnt been explored to its 
full potential, making this an opportunity to make a real difference to 
the future of medical science.
AstraZeneca is a global, innovation-driven biopharmaceutical business that 
focuses on the discovery, development and commercialisation of prescription
medicines for some of the worlds most serious diseases. But we're more 
than one of the world's leading pharmaceutical companies. At AstraZeneca, 
we're proud to have a unique workplace culture that inspires innovation 
and collaboration. Here, employees are empowered to express diverse 
perspectives - and are made to feel valued, energised and rewarded for 
their ideas and creativity.
Our Respiratory, Inflammation and Autoimmunity team offers definitive 
expertise to colleagues across the business. Youll help respiratory 
patients in areas with medical needs that arent being fully met, including
chronic obstructive pulmonary disease and asthma and rheumatic disorders 
tackling these diseases from three areas lung immunity, lung epithelium, 
and lung remodelling/regeneration. Right now, We are a leading figure in 
inhaled drug development, and our new Inhalation Centre in Gothenburg, 
Sweden coupled with our work in new modalities is set to extend that lead 
even further.
The successful candidate will join a truly multi-functional 
cross-disciplinary (computational chemistry, DMPK and Medicinal Chemistry)
in the RIA iMED biotech therapy area and cross-cultural (industry-academia)
team, where interaction with other disciplines (AZ internally and 
externally) will broaden the Postdocs network and enrich his/her experience
 portfolio with an industrial and pharmaceutical experience.
With access to multiple resources, instruments, big data and 
state-of-the-art techniques, there will be the opportunity to interact and 
learn from AZ scientists, world leading academic experts and other 
Postdocs. The Postdoc will join the vibrant international AZ Postdoc 
community and enjoy the diverse training opportunities (including some 
advanced courses in Drug Discovery and Medicinal Chemistry) as well as the
 opportunity to acquire many valuable soft skills not easily developed in 
academic placements.
Accountabilities and Responsibilities:
This is a great opportunity for a highly motivated individual with a strong
 desire to succeed in his/her research career and who is willing to 
contribute to the success of both AZ and the RIA therapy area in the 
New Modalities arena.
You will be expected to work independently under the supervision and 
guidance of world leading scientists from AZ and The University of 
Strathclyde, with an expectation to publish papers in a high-quality 
journal (at least one per year) and attend a conference each year and at 
each occasion present a poster or give an oral presentation.
The supervision of the Postdoc will be done jointly between AZ and the 
University of Strathclyde, where the successful candidate is expected to 
spend some time hosted in the Department of Chemistry and benefitting from
 world-class computational facilities, including the ARCHIE-WeSt 
supercomputing centre (  Training 
opportunities will be provided through the Researcher Development 
Framework (, which can lead to PGCert or PGDip 
Periodic meetings (TC, VC) including F2F meetings will be organised as 
required between Strathclyde advisors , AZ supervisors and Postdoc 
(Evaluate progress, discussions and consulting).
The Postdoc will be involved in real AZ Pharma projects and he/she will 
therefore have the opportunity to contribute to the exciting process of 
designing the drugs of the future.

Education and Experience Required:

As a postdoctoral scientist in cheminformatics specializing in 
computational modelling of permeability the following qualifications are 

o	Highly motivated individual with a strong desire to succeed and 
        the ability to work independently
o	Excellent communication skills in both written and spoken English
o	A PhD in a relevant subject (cheminformatics, computational 
        chemistry, chemistry)
o	Basic knowledge in programming
o	Basic knowledge in machine learning
o	Basic knowledge in Cheminformatics and QSPR modelling
o	Basic Knowledge of molecular modelling

o	Basic knowledge in medicinal chemistry
o	Basic knowledge in phys-chem properties
o	Experience in modelling peptides and macrocycles
o	Proven experience in programming in a language relevant to the 
        project like C++ and/or Python
o	Application of machine learning to relevant scientific problems 
       (prediction of phys-chem properties)
o	Knowledge in Reference Interaction Site Model (RISM) of the 
        Integral Equation Theory
o	Knowledge in quantum chemistry and statistical mechanics

Skills and Capabilities required:
As a RIA DMPK & Cheminformatics Postdoctoral Scientist you will be:
o	Extracting and integrating data sets
o	Applying state-of-the-art machine learning algorithms
o	Calculating novel type of descriptors to be applied to novel 
        beyond-rule-of-5 compounds
o	Interact closely with experimentalists that will validate your 
o	Aiming to publish in high-impact cheminformatics and medicinal 
        chemistry journals

This is a 3 year programme.  2 years will be a Fixed Term Contract, with 
a 1 year extension which will be merit based.  The role will be based at  
AZ Gothenburg (Sweden) with a short stay at the University of 
Strathclyde, Glasgow (Scotland) with a competitive salary on offer.
To apply for this position, please click any of the links below:
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Modified: Wed Apr 4 15:09:35 2018 GMT
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