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Date: Wed May 23 13:40:01 2018
Subject: 18.05.23 Senior Computational Chemist (Fragment-Based Lead Generation)
Position:    Senior Computational Chemist (Fragment-Based Lead Generation)
Location:    Cambridge, UK.
Salary:      Very competitive with excellent benefits

At AstraZeneca we turn ideas into life changing medicines. Working here means being 
entrepreneurial, thinking big and working together to make the impossible a reality.

Our scientific leadership ambition rests on our ability to attract and retain the best 
scientists. We continue to attract senior scientists from academia and industry, who are 
excited by the quality of our science, and the potential of our pipeline that makes the 
Innovative Medicines and Early Development (IMED) Biotech Unit a great place to work.

At the same time, we are committed to inspiring the next generation of scientists by giving 
them opportunities to develop their skills and follow the science they are passionate about. 

This is an opportunity for an experienced computational chemist to play an influential role 
in Fragment Based medicinal chemistry projects across Innovative Medicines at AstraZeneca, 
based in Cambridge UK.  You will guide chemistry design on multiple projects collaborating 
with other computational & medicinal chemists, structural biologists, biophysicists and 
biologists across multiple therapeutic areas. These include Cardiovascular Renal & Metabolic 
disease, Oncology, Neuroscience and Respiratory & Inflammation. This will draw upon your 
ability to work proactively across multiple projects within a dynamic team environment to 
help develop high-quality lead compounds, ultimately leading to new clinical candidate drugs.

With a strong background in modern computational medicinal chemistry techniques for small 
molecule optimisation, structure-based drug discovery and data analysis you will play a key 
role in the success of the global fragment based lead generation group within drug discovery.

We will encourage you to share our passions for drug discovery through publishing your science 
in internationally recognised journals and conferences and contribute to the development of 
computational chemistry and medicinal chemistry disciplines. You will do this by identifying 
and driving improvements and innovations that advance computational capabilities to positively 
impact drug discovery projects.

You will have;
A Ph.D in the area of computational chemistry or B.Sc./M.Sc. degrees with experience of working 
in the area of computational chemistry.

Experience of:
Guiding a team in the application of computational methods to drive compound design.
Identifying opportunities for strategic computational capability enhancements, including liaison 
with external software providers and academia (as required).
Working in a drug discovery unit or fragment chemistry group.
And competence in structure-based and ligand-based design techniques.

Understanding of:
Broader medicinal chemistry concepts and strategy with a track record of applying innovative solutions 
that have positively impacted project delivery.
How computational chemistry contributes to and influences drug discovery projects together with a good 
Appreciation of other relevant disciplines, especially medicinal chemistry and structural biology. 
Working in/across multidisciplinary project teams
Guiding medicinal chemists on the timely application of computational methods and data analytics to 
influence compound design.

Apply now to join us and help turn ideas into life changing medicines!
AstraZeneca is an equal opportunity employer.  AstraZeneca will consider all qualified applicants for employment 
without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, 
race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil 
partnership status, protected veteran status (if applicable) or any other characteristic protected by law.
Please apply on our website by following the link below:
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