|CCL 18.08.21 Chemoinformatics Scientist, DiCE Molecules, Redwood City, CA|
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To: jobs at ccl.net
Date: Tue Aug 21 11:48:26 2018
Subject: 18.08.21 Chemoinformatics Scientist, DiCE Molecules, Redwood City, CA
Chemoinformatics Scientist, DiCE Molecules, Redwood City, CA
DiCE Molecules is focused on the development of DNA-programmed chemical synthesis and its application to drug discovery. Our innovative platform unites the power of directed evolution with organic synthesis to identify and optimize hits against challenging pharmaceutical targets. We are a startup with ~ 25 employees located in Redwood City, California. Join our team and take part in transforming traditional Medicinal Chemistry by performing optimization on a massive scale.
We seek an exceptional chemoinformatics scientist to join our Informatics team. Responsibilities include building and utilizing tools to analyze results from DNA- programmed libraries of small molecules to prioritize hits for resynthesis as well as identifying commercially available building blocks to develop structure activity relationships. The candidate will work closely with the chemistry team during the library design, synthesis, and hit profiling stages on multiple targets and libraries.
Candidate must (i) have a firm understanding of the medicinal chemistry process and drug property design (ii) be comfortable manipulating and drawing conclusions from large datasets, taking many factors and types of data into consideration and (iii) have familiarity and skills in chemoinformatics including physicochemical property prediction, library enumeration, chemical fingerprinting, and substructure searching. Familiarity with tools such as Pipeline Pilot, Vortex/Spotfire, Knime, R, Python, and experience with chemical registration databases (e.g. Dotmatics) is preferred.
Key Skills Required:
Education and Experience:
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