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Up Directory CCL 20.12.14 Two Phd student positions in biomolecular simulation and machine learning for drug design, Edinburgh, UK
From: jobs at ccl.net (do not send your application there!!!)
To: jobs at ccl.net
Date: Mon Dec 14 18:17:30 2020
Subject: 20.12.14 Two Phd student positions in biomolecular simulation and machine learning for drug design, Edinburgh, UK
The Michel lab has two PhD studentship opportunities starting in 
September 2021.

1) ''A hybrid molecular simulation/machine-learning framework for rapid 
and accurate computation of absolute binding free energies of lead-like 
molecules''

42 month CASE PhD studentship in collaboration with Dr Daniel Cole 
(Newcastle University) and Dr Graeme Robb (AstraZeneca Cambridge)
This PhD project will focus on new methodologies that combine molecular 
simulations and machine learning to deliver step-changes in accuracy and 
efficiency of absolute binding free energy calculation of drug-like 
molecules.
See details  

https://www.julienmichel.net/lab/media/attachments/2020/12/14/phd-afe-az-cole-michel-1220.pdf 

Applications will be reviewed as received and until a suitable candidate 
has been identified. 

2) ''A high-throughput FEP pipeline for optimisation of hits into leads for 
novel drug targets''

42 month CASE PhD studentship in collaboration with Dr Tahsin Kellici and 
Dr Inaki Morao (Evotec)

This PhD project will deliver an optimized pipeline for high throughput 
protein-ligand binding free energy calculation studies using open source 
free energy perturbation software. Cutting-edge forcefields and sampling 
methodologies will be implemented and benchmarked on drug-targets of 
current interest in the pharmaceutical industry. 

See details

https://www.julienmichel.net/lab/media/attachments/2020/12/14/phd-rbfe-evotec-michel-1220.pdf

Applications will be reviewed as received and until a suitable candidate
 has been identified.
 Candidates should have or be about to obtain a 2.i or 1st class degree 
in a relevant discipline.
 To apply, please submit initially by email a CV, covering-letter 
describing your previous research experience and reasons for applying, as 
well as the names and email address of two referees in pdf format to 
Dr. Julien Michel julien.michel_._ed.ac.uk.
Informal enquiries are encouraged.
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Modified: Mon Dec 14 23:17:30 2020 GMT
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