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Up Directory CCL 21.01.07 PhD position (m/f/d) in computational chemistry, Heildelberg, Germany
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To: jobs at ccl.net
Date: Fri Feb 12 11:09:51 2021
Subject: 21.01.07 PhD position (m/f/d) in computational chemistry, Heildelberg, Germany

Applications are invited for one PhD student position in the Computational Pharmaceutical Chemistry & Molecular Bioinformatics
group (Prof. Dr. Holger Gohlke; http://cpclab.uni-duesseldorf.de) at the Heinrich-Heine-University, Dsseldorf, Germany.

Title: Functional state modulation of membrane proteins by dynamic association and dissociation

Topic: The central question we intend to investigate within the DFG-funded Collaborative Research Center (CRC) 1208 (Identity
and dynamics of membrane systems From molecules to cellular function) is how dynamic association and dissociation modulates
the functional state of membrane proteins under the condition of conserving their molecular identity.
We will address this question on molecular components central for ethylene perceptionin plants located at the ER and Golgi membranes
(Binder et al., Annu Plant Rev 2012; Gohlke and coworkers, Sci Rep 2018 & 2019). This (multi)membrane system plays a crucial role
in the spatial coordination of dynamic association and dissociation. By molecular simulation and modeling studiesat an atomic level
closely connected with experimental validation studies, we intend to provide insights into the role and transport of the copper cofactor
for ethylene receptor biogenesis and ethylene perception in plants.
As none or only static atomic-level information is available, it is mandatory to develop a conceptual framework of adequate computational
approaches for model building and hypothesis generation and high-content experimental platforms to validate and provide feedback.
The molecular simulation and modeling studies will be performed by the PhD student in the Gohlke lab. The PhD student will work closely
together with scientists of the Groth (http://www.biochemplant.hhu.de/) labs for experimentally validating the established models and
generated hypothesis.

Availability: As of now.

Requirements: Ideal candidates will have a record of excellence and a strong background in computational biochemistry/chemistry or structural
bioinformatics, a high interest in working in an interdisciplinary collaboration, and profound knowledge in state-of-the-art molecular dynamics
simulations (Amber) software, molecular modelling (in particular, protein-protein docking), and QM/MM calculations.

How to apply:
Deadline for applications is April 15, 2021; the starting date is negotiable between now and October 2021. Visit https://www.h-its.org/research/ccc/jobs-ccc/ for more details on the position and application procedure.
For more details about the CCC group visit https://www.h-its.org/research/ccc/. General inquiries should be sent directly to Dr. Ganna (Anya) Grynova: ganna.grynova^^^h-its.org. Applicants should submit a one-page letter of motivation with their on line application: why they are interested in the respective project and how they can contribute to the projects success together with a current CV, and contact data of three references.
Please provide all documents as one PDF file and specify for which position you are applying.
Detailed information about living and studying in Dsseldorf is provided here: http://www.uni-duesseldorf.de/home/leben-in-duesseldorf.html


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