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Up Directory CCL 21.01.08 Senior/Principal Molecular Modeler, Galapagos nv, Romainville, FR
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Date: Fri Jan 8 05:59:16 2021
Subject: 21.01.08 Senior/Principal Molecular Modeler, Galapagos nv, Romainville, FR
Pleased to meet you, we are Galapagos, a dynamic fast growing Biotech
company with offices in Europe in Belgium (Mechelen), France (Romainville
 & Paris), the Netherlands (Leiden), Switzerland (Basel), Italy (Milano),
Spain (Madrid), the UK (London), Germany (Mnchen), and in the US(Boston)

Were in the business of changing lives. In our quest to discover and
develop life-improving medicines we go where no one has ever gone before. 
In every challenge we face, we see new opportunities. We want to 
challenge the impossible. We need thought leaders and rapid thinkers, 
entrepreneurs in spirit and status quo-fighters. Collaborative innovators
and perseverant idealists. We need the best-in-class. In other words, 
we need you.

We are looking for a Senior/Principal Molecular Modeler - Romainville,FR

Scope of the job

As member of the Molecular Modelling & Design team (part of the 
Computational Research group, 10 people), your primary responsibility 
will be the judicious application of computational methods to the 
discovery and optimization of drug candidates.

You will be involved in structure-based (SB) and ligand-based (LB) drug 
design, compound selection and acquisition, HTS data analysis and triage
,virtual screening, statistical modelling, and ADMET prediction. You will
be working closely with medicinal chemists, biologists, DMPK scientists 
and other project team members to define and achieve project goals.

You will also have the opportunity to participate in evaluating, 
developing, implementing and applying new computational methodologies and
strategies. You will identify areas of scientific improvement within 
computational sciences and their potential for application to projects. 

You will contribute to the development of new computational capabilities 
and maintain an up to date awareness of recent literature and current 
developments within the field.

Who are you?

-A Ph.D. degree followed by at least 3 years of experience in 
 computer-aided support to drug discovery projects in a 
 multi-disciplinary project team. Experience in an industrial setting 
 would be an advantage.
-Expertise in structure- and ligand-based drug design, with strong 
 experience in common molecular modelling techniques (protein homology 
 modelling, docking, pharmacophore modelling, target- and ligand-based 
 virtual screening)
-Strong expertise in at least one of the following techniques: ADMET and 
 physicochemical property prediction, machine learning, molecular 
 simulations (MD), FEP, quantum mechanics calculations
-A good background in organic chemistry and a solid knowledge of 
 medicinal chemistry concepts
-Additional required skills:
 Experience with data-workflow tools (such as Pipeline Pilot or Knime)
 Programming, scripting (Python)
 Good knowledge of Linux and awareness of the latest hardware and cloud 
 Knowledge of drug target families (kinases, GPCRs, proteases, PDEs)
 Experience with databases and querying languages (such as SQL) would be 
 a plus

Whats in it for you?

You will be part of a fast growing and amazing company. As 
make-it-happener you will get all the support you need to make your 
job successful. At Galapagos we aim to recruit the best people, who stand
out among their peers, with integrity and excellent interpersonal and 
organizational skills. Our employees are the strength behind Galapagos, 
a highly motivated team, eager to maintain Galapagos leading position 
and achieve breakthroughs in pharmaceutical research. Galapagos offers a 
competitive remuneration package and a dynamic work environment.

We are Galapagos : together we can make it happen!
You can show your interest by sharing your application with Wim Vanhaele,
Talent Acquisition Lead Research - wim.vanhaele** 
Looking forward to speaking with you.
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