Self-Consistent Ensemble Optimization

[gabriel' at \`jg1.bchem.temple.edu (Dr. Jerome L. Gabriel)]

 Dear CCL Members,
 I am interested in applying the Self-Consistent Ensemble Optimization
 method( Christopher Lee, J. Mol. Biol. 236, 918-939, 1994) to predict
 the overal side chain packing for models of various mutant proteins.
 As I understand, the method was developed to predict the effects of
 point mutations on local side chain packing. I also understand that
 the SCEO method has been made available as part of the Look software
 package referred to as the program CARA.
 I would appreciate receiving information on either the CARA program
 or on other methods which could be applied to predict the effects of
 point mutations on local side chain packing.
 I appreciate you help in this matter.
 Thank you
 Jerome L. Gabriel
    Jerome L. Gabriel
    Department of Biochemistry , 407A MRB             HAVE  PROTEIN
    Temple University Medical School
    3420 N. Broad Street                                 -------
    Philadelphia, PA 19140
                                                       WILL  MODEL
    E-mail
    gabriel' at \`jg1.bchem.temple.edu