Subject: Drugs directed to GPCRs

From: Amiram Goldblum <[email-masked]>
Date: Wed, 17 May 2000 14:01 +0300

Dear All,

In its March 17 issue on drug discovery (Vol. 287 No. 5460),
Science published a review on drug discovery that had a diagram
(Fig. 3, p. 1962) of biochemical classes of drug TARGETS of
current therapies. It demonstrates that out of 483 targets, 45%
are receptors, and 7% more are "unknown" targets.

- May we safely assume that more than 45% of those targets are GPCRs ?

In addition, I am looking for the following information (including refereces
if possible):

1. The percentage of drugs on the market that are directed to GPCRs
    (based on the NUMBER of drugs on the market)

2. The percentage of sales of drugs directed to GPCRs out of the
     total sales of drugs (it will be helpful to have both % and $$)

3. A few examples of drugs for GPCRs that were recently ( 5 yrs) introduced.

I thank you in advance and promise to summarize.

Sincerely,

Amiram Goldblum

______________________________________
Amiram Goldblum, Ph.D.
Prof. of Medicinal Chemistry
School of Pharmacy

Hebrew University of Jerusalem, Israel 91120

Tel: 972-2-6758701 FAX: 972-2-6410740
email: [email-masked]
______________________________________