Subject: Re: CCL:Zn ion coordination

From: Laurence Cuffe <[email-masked]>
Date: Mon, 07 Jan 2002 12:44:40 +0000

Date sent:      	Sun, 06 Jan 2002 18:06:20 +0100
From:           	Sergio Manzetti <[email-masked]>
Subject:        	CCL:Zn ion coordination
To:             	Chemistry Discussion G <[email-masked]>

>Dear CCLers, a Zn ion gives me headaches since it occurs hexa-coordinated in
>a molecular simulations, is tricoordinated in the crystal structures, but is
>cited to be tetra- and penta-coordinated at transition states in
>metalloenzymes. The neighbours chelating this Zn-ion are: Imidazole ring,
>Glutamate and a backbone carbonyl oxygen.
>
>Can anybody recommend a good review or publication of Zn in metalloenzymes?
>I have Parkin (2001), but my questions still remains after reading it.
>
Have you seen Nadassy's web site?
www.ebi.ac.uk/~nadassy/analysis.htm
 also Alberts I.L. Nadassy K. Wodak, S. J. Protein science 1998 
7:1700-1716 Analysis of zinc binding sites in protein crystal 
structures
is worth looking at
All the best
Laurence Cuffe
>Best regards and Happy New year
>
>Sergio
>
>
>
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