From chemistry-request@ccl.net Mon Nov 24 09:13:31 2003 Received: from www1.kaist.ac.kr (www1.kaist.ac.kr [143.248.4.46]) by server.ccl.net (8.12.8/8.12.8) with SMTP id hAOECvNL017303 for ; Mon, 24 Nov 2003 09:12:58 -0500 Received: (snipe 12564 invoked by alias); 24 Nov 2003 13:55:09 -0000 Received: from blue_sky_at_kaist.ac.kr with SpamSniper2.71 (Processed in 0.050489 secs); Received: from unknown (HELO kaist.ac.kr) (143.248.5.130) by 0 with SMTP; 24 Nov 2003 13:55:09 -0000 X-RCPTTO: chemistry_at_ccl.net, Received: (qmail 11393 invoked from network); 24 Nov 2003 23:14:41 +0900(KST) Received: from unknown (HELO ilsun) (143.248.37.227) by 0 with SMTP; 24 Nov 2003 23:14:41 +0900(KST) Message-ID: <00bb01c3b295$0ea1c5a0$e325f88f@ilsun> From: "Kwanyong Seo" To: "CCL" Subject: CCL: transition dipole moment Date: Mon, 24 Nov 2003 23:12:55 +0900 MIME-Version: 1.0 Content-Type: multipart/alternative; boundary="----=_NextPart_000_00B8_01C3B2E0.7E525810" X-Priority: 3 X-MSMail-Priority: Normal 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(5.5.2653.19) id ; Mon, 24 Nov 2003 09:31:48 -0800 Message-ID: <73564B8DE398D61180500008C75D7E49033E5DFE@NTMAIL03> From: "Pandey, Jaya" To: "'chemistry*at*ccl.net'" Subject: GLP and GMP Date: Mon, 24 Nov 2003 09:31:47 -0800 MIME-Version: 1.0 X-Mailer: Internet Mail Service (5.5.2653.19) X-WSS-ID: 13DC9E80994312-01-01 Content-Type: text/plain Content-Transfer-Encoding: 7bit X-Spam-Status: No, hits=0.0 required=7.0 tests=none version=2.55 X-Spam-Checker-Version: SpamAssassin 2.55 (1.174.2.19-2003-05-19-exp) Dear All, Is anyone aware of some quality courses on-line or regular for GLP and GMP standards mainly in Los Angeles area. Does one have to get a certificate for getting entry into Industry? Please reply, Thanks, Jaya From chemistry-request@ccl.net Mon Nov 24 13:45:37 2003 Received: from gip2.u-picardie.fr (gip2.u-picardie.fr [193.49.184.4]) by server.ccl.net (8.12.8/8.12.8) with ESMTP id hAOIivNL032359 for ; Mon, 24 Nov 2003 13:45:05 -0500 Received: by gip2.u-picardie.fr (Postfix, from userid 33) id 1216B9AC8; Mon, 24 Nov 2003 19:44:56 +0100 (CET) To: chemistry*at*ccl.net Subject: B3LYP in g98 Message-ID: <1069699496.3fc251a8063a7*at*webmail.u-picardie.fr> Date: Mon, 24 Nov 2003 19:44:56 +0100 (CET) From: FyD MIME-Version: 1.0 Content-Type: text/plain; charset=ISO-8859-1 Content-Transfer-Encoding: 8bit User-Agent: IMP/PHP IMAP webmail program 2.2.6 X-Spam-Status: No, hits=0.0 required=7.0 tests=USER_AGENT version=2.55 X-Spam-Checker-Version: SpamAssassin 2.55 (1.174.2.19-2003-05-19-exp) Hi, I'd like to use b3lyp DFT in g98 with the correlation functional V instead of the functional III. What would be the corresponding keyword to use ? Thanks, Francois From jkl@ccl.net Mon Nov 24 15:13:31 2003 -0500 Return-Path: Message-Id: <5.0.2.1.0.20031124210950.02894480:at:mail.tiscalinet.ch> Date: Mon, 24 Nov 2003 21:12:38 +0100 To: chemistry:at:ccl.net From: Barry Hardy Subject: news from the Cheminformatics Virtual Conference Mime-Version: 1.0 Content-Type: multipart/alternative; boundary="=====================_50271581==_.ALT" X-Spam-Checker-Version: SpamAssassin 2.60 (1.212-2003-09-23-exp) on atlantis.ccl.net X-Spam-Status: No, hits=-4.8 required=9.0 tests=AWL,BAYES_00, HTML_FONTCOLOR_BLUE,HTML_MESSAGE autolearn=no version=2.60 --=====================_50271581==_.ALT Content-Type: text/plain; charset="iso-8859-1"; format=flowed Content-Transfer-Encoding: quoted-printable **** News from the Cheminformatics Virtual Conference Launch **** http://conferences.metalayer.net/echeminfo/ Contents 1. eCheminformatics 2003 Conference: sessions now available 2. Winner of Best Poster Award 3. Next events: November 27 and December 8 4. Knowledge Management in Pharma R&D 1. eCheminformatics 2003 Conference: sessions now available All eCheminformatics 2003 talks from the first week's launch conference are= =20 now available to conference registrants at=20 http://conferences.metalayer.net/echeminfo/ with audio. You can also still= =20 post a question or comment and the Speaker will be alerted. Highlights= include: - Karl Harrison, Oxford University, explains how Grid Computing approaches= =20 have been deployed recently in Smallpox research for the virtual screening= =20 of 35 million compounds to produce ca. 45 promising lead compounds - Miklos Vargyas, Chemaxon, presents a compelling talk on his approach to=20 optimized virtual screening which he shows is capable of reducing the size= =20 of the 'search haystack' by an order of magnitude *** This talk is now=20 available as free access to anyone logged into the site - Alex Tropsha, University of North Carolina, presents a set of convincing= =20 guidelines for developing higher quality validated and predictive QSPR= models - Mark Mackey, Cresset BioMolecular Discovery Ltd, presents a promising=20 approach with promising results on using the surface and shape properties=20 of a molecule described as 'field points' which when combined with a=20 similarity metric allows molecules' field properties to be rapidly compared .........and much more than I have space for here! 2. Winner of Best Poster Award We received some excellent poster contributions at the launch conference=20 and our speaker panel found it was a close choice. In the end, we decided=20 to have one overall winner and award 'silver medals' to two others: Voted Best Poster: 2-Pyridineacetamides: a novel class of Tyrosine Kinases Inhibitors Alessandro Contini, Universita degli Studi di Milano Silver Posters go to: MyMol: web-based molecular database Matteo Floris, University of Padova, and Virtual synthesis with "smart" reactions Gyorgy Pirok, Chemaxon We'd like to thank Bio-Rad for their generous support of Alessandro Contini= =20 and Matteo Floris through the Young Investigators Program. We have invited= =20 both of them to present their work to you (see next events below). All hub members are entitled to submit a poster of their work in the field= =20 of cheminformatics and we very much hope you will soon take advantage of=20 this opportunity. We see this as an important part of the networking=20 aspects of the hub, as it helps people have a 'starting point' for=20 conversation, which could lead to collaboration, which could lead to.... 3. Next events: November 27 and December 8 Thursday, November 27 (11.15 am Eastern Time USA / 4.15 pm GMT UK / 17.15= CET) =B7 2-Pyridineacetamides: a novel class of Tyrosine Kinases= Inhibitors,=20 Alessandro Contini, Universita degli Studi di Milano Monday, December 8 (11.15 am Eastern Time USA / 4.15 pm GMT UK / 17.15 CET) =B7 MyMol: web-based molecular database, Matteo Floris, University of= =20 Padova If you'd like to attend either of these live, via teleconferencing, please= =20 contact us at least 24 hours beforehand! Otherwise, the recorded talks will= =20 be available to temporary or full hub members on the hub within a few hours. 4. Knowledge Management in Pharma R&D On December 1st, Douglas Connect, and Eyeforpharma are also launching a=20 virtual conference and hub for Knowledge Management in Pharma R&D. So if=20 you or colleagues elsewhere in your organisation would like to know more=20 about things like integrating electronic lab notebooks to accelerate=20 discovery, or how enhanced communication applications like blogs and=20 collective intelligence can help you, please go to http://conferences.metalayer.com/km/ best regards, Barry Hardy eCheminformatics Conference Chair Douglas Connect www.douglasconnect.com +41 61 851 0170 (office) --=====================_50271581==_.ALT Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Jon:  I gather tiscalinet.ch is still on your black list there so I am sending this news to you directly for the ccl list.
If you let me know from which address you are receiving the spam on tiscalinet.ch, I will at least alert the ISP with a complaint and see if they can stop it, according to their user policy.
Barry


**** News from the Cheminformatics Virtual Conference Launch=20 ****
http://conferences.metalayer.net/echeminfo/


Contents
1. eCheminformatics 2003 Conference: sessions now available
2. Winner of Best Poster Award
3. Next events: November 27 and December 8
4. Knowledge Management in Pharma R&D

1. eCheminformatics 2003 Conference: sessions now available

All eCheminformatics 2003 talks from the first week's launch conference are now available to conference registrants at http://conferences.metalayer.= net/echeminfo/ with audio. You can also still post a question or comment and the Speaker= will be alerted. Highlights include:

- Karl Harrison, Oxford University, explains how Grid Computing= approaches have been deployed recently in Smallpox research for the virtual= screening of 35 million compounds to produce ca. 45 promising lead= compounds
- Miklos Vargyas, Chemaxon, presents a compelling talk on his= approach to optimized virtual screening which he shows is capable of= reducing the size of the 'search haystack' by an order of magnitude *** This talk is now available as free access to= anyone logged into the site
- Alex Tropsha, University of North Carolina, presents a= set of convincing guidelines for developing higher quality validated and= predictive QSPR models
- Mark Mackey, Cresset BioMolecular Discovery Ltd, presents a= promising approach with promising results on using the surface and shape= properties of a molecule described as 'field points' which when combined= with a similarity metric allows molecules' field properties to be rapidly= compared

.........and much more than I have space for here!


2. Winner of Best Poster Award

We received some excellent poster contributions at the launch= conference and our speaker panel found it was a close choice. In the end,= we decided to have one overall winner and award 'silver medals' to two= others:

Voted Best Poster:
2-Pyridineacetamides: a novel class of Tyrosine Kinases Inhibitors
Alessandro Contini, Universita degli Studi di Milano

Silver Posters go to:
MyMol: web-based molecular database
Matteo Floris, University of Padova, and

Virtual synthesis with "smart" reactions
Gyorgy Pirok, Chemaxon

We'd like to thank Bio-Rad for their generous support of Alessandro Contini= and Matteo Floris through the Young Investigators Program. We have invited= both of them to present their work to you (see next events below).

All hub members are entitled to submit a poster of their work in the field= of cheminformatics and we very much hope you will soon take advantage of= this opportunity. We see this as an important part of the networking= aspects of the hub, as it helps people have a 'starting point' for= conversation, which could lead to collaboration, which could lead= to....


3. Next events: November 27 and December 8

Thursday, November 27 (11.15 am Eastern Time USA / 4.15 pm GMT UK= / 17.15 CET)
=B7       2-Pyridineacetamides: a novel class of Tyrosine Kinases= Inhibitors, Alessandro Contini, Universita degli Studi di Milano
Monday, December 8 (11.15 am Eastern Time USA / 4.15 pm GMT UK / 17.15 CET)=
=B7       MyMol: web-based molecular database, Matteo Floris, University of= Padova
If you'd like to attend either of these live, via teleconferencing,= please contact us at least 24 hours beforehand! Otherwise, the recorded= talks will be available to temporary or full hub members on the hub within= a few hours.


4. Knowledge Management in Pharma R&D

On December 1st, Douglas Connect, and Eyeforpharma are also= launching a virtual conference and hub for Knowledge Management in Pharma= R&D. So if you or colleagues elsewhere in your organisation would like= to know more about things like integrating electronic lab notebooks to= accelerate discovery, or how enhanced communication applications like blogs= and collective intelligence can help you, please go to
http://conferences.metalayer.com/km/

best regards,
Barry Hardy
eCheminformatics Conference Chair
Douglas Connect
www.douglasconnect.com
+41 61 851 0170 (office)






--=====================_50271581==_.ALT-- From chemistry-request@ccl.net Mon Nov 24 18:42:57 2003 Received: from web21205.mail.yahoo.com (web21205.mail.yahoo.com [216.136.131.248]) by server.ccl.net (8.12.8/8.12.8) with SMTP id hAONgQNL010499 for ; Mon, 24 Nov 2003 18:42:26 -0500 Message-ID: <20031124234225.24171.qmail-.at.-web21205.mail.yahoo.com> Received: from [129.109.59.107] by web21205.mail.yahoo.com via HTTP; Mon, 24 Nov 2003 15:42:25 PST Date: Mon, 24 Nov 2003 15:42:25 -0800 (PST) From: IEJMD Subject: IECMD 2003 - Program for the first day, November 24, 2003 To: chemistry-.at.-ccl.net MIME-Version: 1.0 Content-Type: text/plain; charset=us-ascii X-Spam-Status: No, hits=0.0 required=7.0 tests=none version=2.55 X-Spam-Checker-Version: SpamAssassin 2.55 (1.174.2.19-2003-05-19-exp) Internet Electronic Conference of Molecular Design 2003, IECMD 2003, November 23 - December 6, http://www.biochempress.com All accepted papers are posted on the Web and can be downloaded as PDF files from http://www.biochempress.com All discussions of the IECMD 2003 papers will take place on the Web, using the Yahoo! group iecmd2003, http://groups.yahoo.com/group/iecmd2003 Please visit the IECMD 2003 discussion site at http://groups.yahoo.com/group/iecmd2003 to sign-up and send comments to the group. IECMD 2003 - Program for the first day, November 24, 2003 1. IECMD 2003, paper 9 A New Generalized Concept of Chemical Reactivity and Selectivity Pratim Kumar Chattaraj and Utpal Sarkar 2. IECMD 2003, paper 11 Fluorine-Substituted Phenols as Probes to Study Intermolecular Proton Transfer Induced by Excess Electron Attachment to Uracil-Phenol Complexes Maciej Haranczyk and Maciej Gutowski 3. IECMD 2003, paper 47 Synthesis, crystal structure and feasibility of intramolecular proton transfer reaction of salicylaldazine Md. Mijanuddin, W. S. Sheldrick, H. Mayer-Figge, Mahammad Ali, and Nitin Chattopadhyay 4. IECMD 2003, paper 18 Computer-Aided Design of Selective COX-2 Inhibitors: Molecular Docking of Structurally Diverse Cyclooxygenase-2 Inhibitors using FlexX Method Asit K. Chakraborti and Ramasamy Thilagavathi 5. IECMD 2003, paper 31 Neural Networks for Secondary Metabolites Prediction in Artemisia Genus (Asteraceae) Tanja Schwabe, Marcelo J. P. Ferreira, Sandra A. V. Alvarenga, and Vicente P. Emerenciano 6. IECMD 2003, paper 55 Intermolecular Interaction in C60-Based Electron Donor-Acceptor Complexes Elena F. Sheka ===== Dr. Ovidiu Ivanciuc Sealy Center for Structural Biology Department of Human Biological Chemistry & Genetics University of Texas Medical Branch 301 University Boulevard Galveston, Texas 77555-1157 USA __________________________________ Do you Yahoo!? Free Pop-Up Blocker - Get it now http://companion.yahoo.com/ From chemistry-request@ccl.net Mon Nov 24 15:20:35 2003 Received: from uis-gumail-1.georgetown.edu (postoffice-1.georgetown.edu [141.161.1.18]) by server.ccl.net (8.12.8/8.12.8) with ESMTP id hAOKK3NL004366 for ; Mon, 24 Nov 2003 15:20:03 -0500 Received: from georgetown.edu (mailhost.georgetown.edu [141.161.1.103]) by uis-gumail-1.georgetown.edu (8.12.10/8.12.10) with ESMTP id hAOKK3vq006261 for ; Mon, 24 Nov 2003 15:20:03 -0500 (EST) From: To: chemistry.-at-.ccl.net Message-ID: Date: Mon, 24 Nov 2003 12:20:03 -0800 X-Mailer: Netscape Webmail MIME-Version: 1.0 Content-Language: en Subject: Docking program web sites X-Accept-Language: en Content-Type: text/plain; charset=us-ascii Content-Disposition: inline Content-Transfer-Encoding: 7bit X-GU-FilterVersion: 1.22 X-Scanned-By: MIMEDefang 2.36 X-Spam-Status: No, hits=1.4 required=7.0 tests=FROM_ENDS_IN_NUMS,NO_REAL_NAME,X_ACCEPT_LANG version=2.55 X-Spam-Level: * X-Spam-Checker-Version: SpamAssassin 2.55 (1.174.2.19-2003-05-19-exp) Dear CCL-ers: Where can I find various different docking programs (protein-protein, protein-ligand, protein-DNA) with their web Links. Thanks in advance, Sincerely, Sivanesan D.Sivanesan, Ph.D. Dept. of Oncology, Lombardi Cancer Center (NCI Comprehensive Cancer Center), Georgetown University, DC 20057 Phone: 202-687-6338 From chemistry-request@ccl.net Mon Nov 24 15:13:42 2003 Received: from bureau14.utcc.utoronto.ca (bureau14.utcc.utoronto.ca [128.100.132.42]) by server.ccl.net (8.12.8/8.12.8) with ESMTP id hAOKDANL004048 for ; Mon, 24 Nov 2003 15:13:10 -0500 Received: from mditdell.mdit.utoronto.ca ([128.100.251.12] HELO MditDell ident: IDENT-NOT-QUERIED [port 1106]) by bureau14.utcc.utoronto.ca with SMTP id <890284-11080>; Mon, 24 Nov 2003 15:12:31 -0500 From: "William Wei" To: "CCLers" Subject: Gaussian: Error on Z-matrix card number Date: Mon, 24 Nov 2003 15:15:57 -0500 Message-ID: MIME-Version: 1.0 Content-Type: text/plain; charset="iso-8859-1" Content-Transfer-Encoding: 7bit X-Priority: 3 (Normal) X-MSMail-Priority: Normal X-Mailer: Microsoft Outlook IMO, Build 9.0.2416 (9.0.2910.0) Importance: Normal X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2727.1300 X-Spam-Status: No, hits=-0.4 required=7.0 tests=MSGID_GOOD_EXCHANGE version=2.55 X-Spam-Checker-Version: SpamAssassin 2.55 (1.174.2.19-2003-05-19-exp) Dear CCLers, If I run relaxed Potential Energy Surface (PES) scan under Gaussian 98, the Z-Matrix card error always comes to me. ...... Error on Z-matrix card number 11 angle Alpha is outside the valid range of 0 to 180. Conversion from Z-matrix to cartesian coordinates failed: ...... I explored on this issue. There are two possible situations related to this. One is the Z-Matrix definition on ring system. The other is the torsional angle reaching 0 degree. (Please let me know if I am wrong.) Did anyone meet these problem before? Could you please give me a suggestion? I will summary the result. Thank you and have a good day, William ------------------------- William Wei Molecular Design and Information Technology (MDIT) center Faculty of Pharmacy, University of Toronto 19 Russell Street, Toronto, ON. M5S 2S2 Tel: 1-416-946-8469 Fax: 1-416-978-8511 Email: william.wei.-at-.utoronto.ca william.-at-.phm.utoronto.ca From chemistry-request@ccl.net Mon Nov 24 15:17:39 2003 Received: from roche.bath.ac.uk (roche.bath.ac.uk [138.38.32.21]) by server.ccl.net (8.12.8/8.12.8) with ESMTP id hAOKH7NL004216 for ; Mon, 24 Nov 2003 15:17:07 -0500 Received: from mary.bath.ac.uk ([138.38.32.14] ident=mmdf) by roche.bath.ac.uk with smtp id 1AON8t-0007wv-6f; Mon, 24 Nov 2003 20:17:07 +0000 Received: from prpcn144 ( prpc-n144.bath.ac.uk [138.38.128.144] ) by bath.ac.uk id aa11502 ; 24 Nov 2003 20:17 +0000 From: James Robinson To: "Pandey, Jaya" Cc: Chemistry Subject: RE: GLP and GMP Date: Mon, 24 Nov 2003 20:18:16 -0000 Message-ID: MIME-Version: 1.0 Content-Type: text/plain; charset="iso-8859-1" X-Priority: 3 (Normal) X-MSMail-Priority: Normal X-Mailer: Microsoft Outlook IMO, Build 9.0.2416 (9.0.2911.0) Importance: Normal In-Reply-To: <73564B8DE398D61180500008C75D7E49033E5DFE@NTMAIL03> X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2600.0000 X-Scanner: 39f8f401e24ad4743107126db4a6b110f47bd7ff X-Spam-Status: No, hits=-1.4 required=7.0 tests=IN_REP_TO,MSGID_GOOD_EXCHANGE,ORIGINAL_MESSAGE version=2.55 X-Spam-Checker-Version: SpamAssassin 2.55 (1.174.2.19-2003-05-19-exp) Content-Transfer-Encoding: 8bit X-MIME-Autoconverted: from quoted-printable to 8bit by server.ccl.net id hAOKHdNL004235 In the UK, there is an excellent book by the MCA (medicines control agency, "the orange guide") and there is apparently a USA equivalent published by the FDA. GMP should be referred to a cGMP, or current good manufacturing practise. GLP and cGMP are careful working practises to track the status of a process and adherence should reflect in a reproducible product quality. A search should produce some good websites on the web. As for a certificate, ummm, if memory serves in the UK one can become a Qualified Person, but such people are concerned with following paperwork not neccessarily performing comp chem or modelling. I do hope such regulations never apply to modelling! Imagine that, given a notice by the FDA because your optimisation point only has a gradient of 0.0123 instead of 0.0099, wonder if would ever apply to operating systems too. The mind boggles! James -----Original Message----- From: Computational Chemistry List [mailto:chemistry-request.-at-.ccl.net]On Behalf Of Pandey, Jaya Sent: 24 November 2003 17:32 To: 'chemistry.-at-.ccl.net' Subject: CCL:GLP and GMP Dear All, Is anyone aware of some quality courses on-line or regular for GLP and GMP standards mainly in Los Angeles area. Does one have to get a certificate for getting entry into Industry? Please reply, Thanks, Jaya -= This is automatically added to each message by the mailing script =- To send e-mail to subscribers of CCL put the string CCL: on your Subject: line and send your message to: CHEMISTRY.-at-.ccl.net Send your subscription/unsubscription requests to: CHEMISTRY-REQUEST.-at-.ccl.net HOME Page: http://www.ccl.net | Jobs Page: http://www.ccl.net/jobs If your mail is bouncing from CCL.NET domain send it to the maintainer: Jan Labanowski, jkl.-at-.ccl.net (read about it on CCL Home Page) -+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+ From chemistry-request@ccl.net Mon Nov 24 18:29:22 2003 Received: from smtp4.dti.ne.jp (smtp4.dti.ne.jp [202.216.228.39]) by server.ccl.net (8.12.8/8.12.8) with ESMTP id hAONSiNL010335 for ; Mon, 24 Nov 2003 18:28:50 -0500 Received: from oemcomputer (PPP105.fukuoka-ip.dti.ne.jp [211.132.92.105]) by smtp4.dti.ne.jp (3.08s) with SMTP id hAONSerL004394 for ; Tue, 25 Nov 2003 08:28:42 +0900 (JST) Message-ID: <004701c3b2e1$b370b680$695c84d3@oemcomputer> From: "Telkuni" To: Subject: "%mem" trouble of Gaussian Date: Tue, 25 Nov 2003 08:21:33 +0900 MIME-Version: 1.0 Content-Type: text/plain; charset="Windows-1252" Content-Transfer-Encoding: 7bit X-Priority: 3 X-MSMail-Priority: Normal X-Mailer: Microsoft Outlook Express 6.00.2800.1106 X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2800.1106 X-Spam-Status: No, hits=0.0 required=7.0 tests=none version=2.55 X-Spam-Checker-Version: SpamAssassin 2.55 (1.174.2.19-2003-05-19-exp) Hello, CCLers. I like to ask the effect of "%mem=xxx" on Gaussian98W. I've met curios phenomenon with G98W_ver.A7. However I modified the PC's memory "%mem=128MB" to "%mem=512MB" on same calculation, there was very little calc time difference between them(57min and 64 min!) If anyone met same phenomenon, please let me know. All responses, I will appreciate. And I will summarize them. Sincerely yours, ---------------------------------------------------- Telkuni Tsuru telkuni[at]venus.dti.ne.jp