From owner-chemistry@ccl.net Mon Nov 24 07:00:01 2014 From: "Violeta Perez pereznueno^_^harmonicpharma.com" To: CCL Subject: CCL: DEADLINE abstracts submission: "Quantitative and Systems Pharmacology" Message-Id: <-50777-141124043749-17809-Vh7ykWOmB+6Xia8PGRZBBQ[a]server.ccl.net> X-Original-From: "Violeta Perez" Date: Mon, 24 Nov 2014 04:37:47 -0500 Sent to CCL by: "Violeta Perez" [pereznueno(a)harmonicpharma.com] This is a reminder for the "Quantitative and Systems Pharmacology: Thinking in a wider "systems- level" context accelerates drug discovery and enlightens our understanding of drug action" at the 3rd International Work-Conference on Bioinformatics and Biomedical Engineering (IWBBIO 2015), 15-17 April, 2015. Granada (SPAIN). (http://iwbbio.ugr.es/) Deadline for abstracts submission: November 30th, 2015 Quantitative and Systems Pharmacology (QSP) is an emerging discipline focused on identifying and validating drug targets, understanding existing therapeutics and discovering new ones. The goal of QSP is to understand, in a precise, predictive manner, how drugs modulate cellular networks in space and time and how they impact human pathophysiology. (QSP White Paper - October, 2011) Over the past three decades, the predominant paradigm in drug discovery was designing selective ligands for a specific target to avoid unwanted side effects. However, in the current post-genomic era, the aim is to design drugs that perturb biological networks rather than individual targets. The challenge is to be able to consider the complexity of physiological responses to treatments at very early stages of the drug development. In this way, current effort has been put into combining chemogenomics with network biology to implement new network-pharmacology approaches to drug discovery; i.e. polypharmacology approaches combined with systems biology information, which advance further in both improving efficacy and predicting unwanted off-target effects. Furthermore, the use of network biology to understand drug action outputs treasured information, i.e for pharmaceutical companies, such as alternative therapeutic indications for approved drugs, associations between proteins and drug side effects, drugdrug interactions, or pathways and gene associations which provide leads for new drug targets that may drive drug development. Following the line of QSP Workshops I and II (2008, 2010), the QSP White Paper (2011), or QSP Pittsburgh Workshop (2013), the goal of this symposium is to bring together interdisciplinary experts to help advance the understanding of how drugs act, with regard to their beneficial and toxic effects, by sharing new integrative, systems-based computational or experimental approaches/ tools / ideas which allow to increase the probability that the newly discovered drugs will prove therapeutically beneficial, together with a reduction in the risk of serious adverse events. A list of contributions with very high quality will be selected to be extended and submitted in different special issues (Biomedical Engineering Online (BMC), Current Bioinformatics, Genomics and Computational Biology, Current Topics in Medicinal Chemistry). More information can be found at: http://iwbbio.ugr.es/issues.php DEADLINE SUBMISSION OF PAPERS: November 30th, 2015 Submission must be done through the submission platform: https://easychair.org/conferences/? conf=iwbbio2015. There are two different categories for submissions: Full paper contributions (published under Lecture Notes in Bioinformatics (LNBI)) and Abstract contributions (published in the conference proceedings under both ISBN and ISSN references). More information can be found at: http://iwbbio.ugr.es/submissions.php IMPORTANT DATES: http://iwbbio.ugr.es/index.php You can learn more about IWBBIO by visiting the website http://iwbbio.ugr.es/index.php I am happy to answer any of your questions. Thank you. Best regards, Violeta Isabel Perez Nueno -- Violeta I. Perez-Nueno, Ph.D. Senior Scientist Harmonic Pharma 615 rue du Jardin Botanique 54600 Villers ls Nancy - France Cell +33(0) 638 878 547 ; Tel +33(0) 354 958 604 Fax +33(0) 383 275 652 pereznueno{=}harmonicpharma.com W:http://www.loria.fr/~pereznue/ www.harmonicpharma.com