Subject: Alzheimer's disease studies

From: [email-masked] (Douglas Smith)
Date: Thu, 15 Sep 1994 16:47:35 -0500 (EDT)

Bill Welsh recently asked for modeling papers related to Alzheimer's disease.
Here are three papers we have published in this area:

William S. Messer, Jr.*, Brenda R. Ellerbroch, Douglas A. Smith and 
Wayne Hoss, 
"Regional Differences in the Binding of Pirenzepine and AF-DX 116 to Rat 
Brain:  Comparison with Minimum Energy Conformations," 
J. Med. Chem. 1989, 32, 1164 - 1172.
 
Delores Collins#, Douglas A. Smith and William S. Messer, Jr.*, 
"Regional Binding of 4-Diphenylacetoxy-N-methylpiperidine Methobromide 
(4-DAMP) to Muscarinic Receptors in Rat Brain and Comparative Analysis of 
Minimum Energy Conformations," 
Neurochem. Int. 1993, 22, 237 - 247.
 
Philip G. Dunbar, Graham J. Durant, Taikyun Rho, Babatunde Ojo, James 
Huzl, Douglas A. Smith, Afif A. El-Assadi, Sbeih Sbeih, Dan O. Ngur, 
Sumudra Periyasamy, Wayne P. Hoss and William S. Messer, Jr. *, "Design, 
Synthesis, and Neurochemical Evaluation of 
2-Amino-5-alkoxycarbonyl-3,4,5,6-tetrahydropyridines and 
2-Amino-5-alkoxycarbonyl-1,4,5,6-tetrahydropyrimidines as M1 Muscarinic 
Receptor Agonists," 
J. Med. Chem., 1994, 37, 0000.

Doug
-- 

Douglas A. Smith
Theoretical Chemist
Concurrent Technologies Corporation
1450 Scalp Avenue
Johnstown, PA 15904

voice:  (814) 269-2545
fax:    (814) 269-2798
email:  [email-masked]  !!!NEW!!!

Stadnard Disclamur: All opinions, comments, mistakes, endorsements and odd
noises are my own, not my employer's.

and still:

Douglas A. Smith                        voice:  N/A
Associate Professor                     fax:    N/A
Department of Chemistry                 email:  [email-masked]
 and
Center for Drug Design and Development
The University of Toledo
Toledo, OH  43606-3390

+---------------------------------+---------------------------------+
| "The juvenile sea squirt wanders through the sea searching for    |
|  a suitable rock or hunk of coral to cling to and make its home   |
|  for life.  For this task it has a rudimentary nervous system.    |
|  When it finds its spot and takes root, it doesn't need its       |
|  brain any more so it eats it.  It's rather like getting tenure." |
|    --source unknown                                               |
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