

Jeremy,

Could you check out this reference and see if it is of any
use to you? I'd be interested to know what you think. The
authors have in fact offered to make available a 
program. 

P Koehl & M Delarue, "Polar and Nonpolar Atomic Environments
in the Protein Core: Implications for Folding and Binding",
PROTEINS: Structure, Function and Genetics 20:264-278 (1994).

You should also hear from people working in site directed
mutagensis, I understand they have other programs too.

-- 

Harold Cox | [email-masked]
           | 510 231 1008  

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