

Dear Jeremy,

We have attempted modeling a mutant HIV-1 protease N88Q.  This single mutation
is known to prevent dimerization of the protease subunits.  We were able to
observe a destablization of the dimer interface by studying the MD trajectory
for 100ps.  We used WESDYN an MD package developed at Wesleyan University by S.
Swaminathan.  Our results were published in J. Am. Chem. Soc. (1993) 115,
1231-1234.

Hope this helps.

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