Subject: Zn++ Coordinated by Cys or Cys- ?

From: "Gerald Loeffler" <[email-masked]>
Date: Wed, 29 Mar 1995 09:19:07 +0100

Hi!

Imagine Zn++ being coordinated by 3 Cys and 1 His in a Zinc Finger.

Do you think it is likely that the Cys looses its S-bound proton (at neutral
pH) because of the influence of the Zn++ ?

This would mean, that the Zn++ is coordinated by 3 (negative) Cys- and 1
(neutral) His (the His holding a partial negative charge on one N).

	Thanx for your time and efforts,
	gerald

P.S.: The pKa of Cys should be 8.5 !
--
Gerald Loeffler
PhD student in Theoretical Biochemistry

Email: [email-masked]
Phone: +43 1 40480 612
Fax:   +43 1 4028525
Mail:  University of Vienna
       Institute for Theoretical Chemistry
       Theoretical Biochemistry Group
       Waehringerstrasse 17/Parterre
       A-1090 Wien, Austria

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