Subject: Chicago computational chemistry club seminar

From: "Shashi Rao" <[email-masked]>
Date: Fri, 4 Aug 1995 16:34:38 -0500

August 4, 1995

Chicago Computational Chemistry Club (CCCC)

Dear CCCC participant,

The next seminar talk under the CCCC auspicies will be held on
Friday, the 18th August, 1995 at Searle R & D facilities, as outlined below.

Speaker :	Professor Terry P. Lybrand
		University of Washington
		Molecular Bioengineering Program

Title :		Strategies and Techniques for Membrane Protein Modeling

Venue :		Searle Research and Development,
		Conf. Rm. A-3B&C,
		4901 Searle Parkway,
		Skokie IL 60077.

Date :		AUGUST 18, 1995.

Pizza and soft drinks will be served from 6:30 - 7:30.

Participants in the 210th National ACS meeting who happen to be in Chicago
on the 18th August, are most welcome to attend the seminar.

Please give us a call or e-mail, if you can make it (shashi rao :708-982-4545,
e-mail : [email-masked] ; Charles Hutchins  :
[email-masked]
(708)-937-4971). If you cannot attend, please call anyway to confirm or
change your address.

Hope to see you again soon.

Best wishes,

Shashi Rao

================================================================

The Chicago Computational Chemistry Club

Presents

Professor Terry P. Lybrand
University of Washington
Molecular Bioengineering Program

"Strategies and Techniques for Membrane Protein Modeling"

Friday, the 18th August, 1995 at 7:30 p.m.

Abstract:
========

Integral membrane receptor proteins frequently
mediate signal transduction across cell membranes in both
bacteria and higher organisms.  As these receptors often
play a key role in regulation of important physiologic
processes, they can be attractive drug therapy
targers.  Detailed understanding
of the three-dimensional structures of these receptor
proteins would undoubtedly contribute greatly to a
general understanding of the molecular mechanisms of
signal transduction and facilitate structure-based
drug design efforts, but formidable technical challenges
prohibit the routine determination of high resolution
structures for most membrane proteins at present.  In
favorable cases, molecular modeling studies can be
coupled with appropriate biophysical experiments to
generate plausible 3D models for some membrane receptor
proteins.  Projects to generate 3D structures for several
bacterial and mammalian membrane receptor proteins will
be presented, and some modeling techniques and experimental
biophysical methods that have proven most useful in these
exercises will be discussed.

Directions :
===========

To get to Searle, exit on Dempster (East) from I-94 (Edens expressway).
Turn right (South) on Skokie Blvd (Rt. 41). After crossing the signal light
at Main street, turn right (West) into Searle parkway. The visitor
parking lot is on the north side of the road after crossing two railroad
tracks. Enter the building at the East end and check with the security guard
house. As earlier, one of us will lead the way to the seminar room. For any
questions on the directions, please call shashi rao @ 708-982-4545.