Subject: pKa of metal-bound water in protein active site

From: [email-masked] (Mark Murcko)
Date: Wed, 16 Aug 1995 19:00:12 -0500 (EDT)

Hello all.  I am looking for references to experimental data
for the pKa's of water molecules bound to metals in protein
active sites.  In general, it is well known that the pKa comes
down a great deal -- but what I want to know is any specific
examples that people are aware of.  Also, if there is a good
review of the experimental data for metal - water pKa's in
general (not just in the active site of proteins) that would
be helpful too.  Thanks in advance! / Mark ([email-masked])