Subject: heparin

From: Bernard Pirard <[email-masked]>
Date: Wed, 16 Aug 95 11:35:37 +0100

Dear colleagues,

	Last year, David D R Devan from the
Department of Biochemistry of the University of
Virginia asked the followin question : 

"We are studying the ability of polyanions to
act as enzymes inhibitors. The polyanions that
we are using include heparin, dermatan sulfate,
chondroitian sulfate, polygalacturonic acid,
polyaspartic acid and polyglutamic acid. As
part of these studies, we would like to
generate computer models of the interaction of
the polyanions with enzymes. I can find
structures of short segments chondroitan
sulfate in the Brookhaven PDB and some
structural information for polyaminoacids
(though at low pH). Can anyone provide
information (reference for better coordinates
for the models themselves) about models that
have developed for these or other polyanions.
We are especially interested in structural
models of heparin".

	I would like to get a summary of the
answers to this question. In addition, have
additional papers been published in this field
since last year. I will mail a summary of the
answers. 

	Many thanks in advance, 

	Best regards, 

	Bernard Pirard
	Research Assistant
	Laboratoire de Chimie Moleculaire
	Structurale 
	rue de Bruxelles, 61
	B-5000 Namur Belgium

	E-mail [email-masked]
	Fax 32 81 72 45 30
	Tel 32 81 72 45 69