Subject: cavity volume calculation

From: Qu Chunxu <[email-masked]>
Date: Tue, 21 Nov 95 10:36:23 JST

Dear netters,

I met a problem on cavity volume calculation.

I am studying on the thermostability of 3-isopropylmalate dehydrogenase. 
Protein engineering showed that at a certain site, Ala-->Leu mutation 
increased the stability of protein. Crystallography analysis showed that the 
sidechain of Leucine reduced the cavity around mutation site. Although the
dot surface illustration can show this point very well, we are asked to give 
the cavity volume in each case. However, we have no such a program. Could you 
help me? Thanks in advance.

your sincerely

Chunxu Qu

Chunxu Qu
Faculaty of Bioscience & Biotechnology
Tokyo Institute of Technology
Japan