From: [email-masked] (Margarita Abagyan)
Date: Tue, 30 Jan 1996 16:53:12 -0800

Dear Soumya,

  ICM is a unique program which not only allows you to perform efficient local can global
energy optimization with any number of rigid blocks in your molecule(s), but also
has an elaborate energy function including vacuum energy, free energy of solvation if
your molecule is in aqueous solution and surface energy and several types of restraints.
  To perform local energy minimization of two ridig molecules you invoke the following
commands:
build "myMolecules"
display   # the program has excellent graphics and you can see minimization on the screen 
fix v_//*         # fix all the variables
unfix v_2//?vt*   # unfix positional variables of the second molecule
minimize

for global energy optimization and docking one molecule to the other you say

montecarlo 

You can just as easily unfix any subset of potentially important variables, say, on
the molecular surface.
With ICM you can also manually dock two rigid molecules on the screen.
You can obtain some information about us and the ICM program at
http://biosoft.com

If you would like to get a complete version with the program manual for trial 
let me know. If you have an SGI workstation, I would need the output of the
sysinfo -s command

With best regards,
Rita,
Biosoft