Subject: difference between piperidine and piperazine

From: kanzaki <[email-masked]>
Date: Fri, 10 Jan 1997 10:22:02 +0900

Dear Netters,

	Does anyone know the sterical and/or electrostatical differences
between
phenyl piperidine and phenyl piperadine. They are show very similar
optimized structure 
optimized by MOPAC. But I observed that the affinity for some protein
are changed if phenyl piperidine are substituted with phenyl piperazine
in a compound.
  
Thanks for any comments

-- 
KANZAKI KOJI( Yoshitomi Pharmaceutical Industries, LTD )
7-25 Koyata 3-chome, Iruma-shi, Saitama, 358, JAPAN  
e-mail: [email-masked]
Fax:    +81-429-63-3121
Phone:    +81-429-64-1906