Subject: DNA base triplexes

From: [email-masked]
Date: Tue Apr 22 10:41:48 1997 (GMT + 0530)

Dear Sirs :
	Are there any theoretical investigations regarding stabilities
of DNA base triplexes ? How reliable are such results ? The experimental
studies involve studies on oligomeric systems. Is it possible to relate 
the stabilities of isolated triplets to the results of UV melting 
experiments ?
	Another important problem is how to calculate the interaction
energy of a trimer using ab initio method if applied to the supermolecule
as well as fragment monomers. Any comments ?
	Thanks a lot.

Shridhar Gadre ([email-masked] & [email-masked])
Department of Chemistry
University of Pune 411007
INDIA.