Subject: Re: CCL:logP and solubility for Amino Acids and peptides

From: Jeremy R Greenwood <[email-masked]>
Date: Fri, 14 Nov 1997 01:24:25 +1100 (EST)

Dear CCL:

Wang Arthur asked:

> We are currently on a project of de novo protein design. A set of scales 
> which describe the hydrophobicities of the natural amino acids is what we 
> badly need. 

> (2) LogP values for the 20 natural amino acids and oligopeptides (up to 
> buta- or pentapeptides). 

I ask, while we're on the subject: 

It seems the accurate de novo determination of LogP for novel amino acids 
and zwitterionic analogues is by no means an easy task. Suggestions and
references gratefully received and summarised.

Jeremy Greenwood
Department of Pharmacology
University of Sydney