Subject: Re: CCL:Examples for Main Chain Flexible Docking

From: <[email-masked]>
Date: Thu, 13 Nov 1997 17:43:37 +0100

---------------------------- Forwarded with Changes ---------------------------
From: Steve Bowlus at USPAC01M
Date: 11/12/97 7:58AM
To: [email-masked] at INTERNET1
Subject: Re: CCL:Examples for Main Chain Flexible Docking
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A recent example of large shifts upon ligand binding is adenylosuccinate
synthase.  Compare the apoenzyme (1ade, 1adi from PDB) with ligated/inhibited
enzyme (1juy, 1gin, for example; there are a number of structures deposited)

sb

_______________________________________________________________________________
Subject: CCL:Examples for Main Chain Flexible Docking
From:    [email-masked] at INTERNET1
Date:    11/12/97  10.17 AM

Dear CCLers:

We are studying main chain flexibility in protein-protein or
protein-ligand docking. We would like to find some examples where
protein main chain conformation changes significantly when binds with
other molecule. Could someone give me a few examples?

Thanks in advance.

Luhua Lai

-----------------------------------------
   Luhua Lai
   Institute of Physical Chemistry
   & Department of Chemistry
   Peking University
   Beijing 100871
   CHINA
   Phone: 86-10-62751490
   Fax:   86-10-62751725
   E-mail: [email-masked]
-----------------------------------------

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