Subject: CoMFA with covalent drug-receptor interaction.

From: Somsak Tonmunphean <[email-masked]>
Date: Tue, 30 Dec 1997 15:10:19 +0100 (CET)

Dear CCL members,
	Since CoMFA, Comparative Molecular Field Analysis (3D-QSAR), is
based on the assumption that drug-receptor interaction is *non-covalent*,
I would wonder if I apply this method to compounds that drug-receptor
interaction is covalent, are meaningful results possible ?? 
	Thank you very much in advance for your help.

Yours,
Somsak Tonmunphean, Ph.D. student
Department of Chemistry, Faculty of Science,
Chulalongkorn University, Bangkok 10330 Thailand.