Subject: The 1998 Charleston Conference

From: "Allen Richon" <[email-masked]>
Date: Tue, 3 Feb 1998 11:23:16 -0400

There are a limited number of spaces remaining for the 1998 Charleston
Conference. If you are interested in attending, please send E-mail to
[email-masked].

The 1998 Charleston Conference
Innovative Techniques for New Lead Discovery and Development
March 9-11, 1998
Wild Dunes Resort
Isle of Palms, South Carolina

Following the highly acclaimed 1997 Charleston Conference, Network
Science Corporation is pleased to announce the distinguished speaker
list for the 1998 conference. This unique annual meeting combines
presentations by industry leaders and an informal atmosphere that affords
the opportunity to interact with colleagues from all phases of research.
Participants will explore the ways in which the industry is increasing the
productivity of the discovery process. We hope you will join us at Wild
Dunes.

Sunday, March 8

8:00 PM: 	Conference Reception

Monday, March 9

8:00 - 12:00: 	De Novo and Combinatorial Library Design
		Session Chair: Christine Humblet
		Senior Director, Biomolecular Structure and Drug
		Design, Parke-Davis Research, Warner Lambert

		Charles J. Eyermann
		Principal Scientist, ARIAD Pharmaceuticals
		Presentation: Computational Tools for Maximizing the
		Diversity and Druglike Character of Focused Libraries

		Irwin ("Tack") D. Kuntz
		University of California, San Francisco
		Presentation: Combinatorial Chemistry Calculations

		William Ripka
		Senior Vice President, Chemical Research,
		Corvas International, Inc.
		Presentation: A Novel Approach to Ligand Design
		Utilizing Distance Geometry and the 'Privileged
		Structure' Concept

		Michael L. Connolly
		Computer Consultant
		Presentation: Classifying Substrate-Binding Regions
		on Proteins by Shape

1:00 - 4:00:	High Throughput Screening in ADME/Toxicology
		Session Chair: Kate Johnston
		Head, Biomolecular Research,
		Sphinx Pharmaceuticals, Eli Lilly

		Oliver Flint
		Principal Scientist, Bristol-Myers Squibb
		Presentation: High Throughput Toxicity Testing of
		Pharmaceuticals

		Jerome Hochman
		Research Fellow, Merck Research Laboratories
		Presentation: Application of Cell Culture Models to the
		Evaluation of Drug Absorption and Drug Metabolism

		Ping Yang Yeh
		Investigator, Drug Delivery, SmithKline Beecham
		Presentation: Combinatorial Screening Approaches for
		Selection of Development Candidates

6:30 - 7:30:	Poster Session

7:30 PM:	Dinner - Sponsored by Molecular Solutions, Inc.

Tuesday, March 10

8:00 - 12:00:	Natural Products as a Source for New Leads
		Session Chair: John Devlin
		President, MicroBotanica, Inc.

		John Beutler
		Special Expert, Laboratory of Drug Discovery
		Research and Development, NCI
		Presentation: Informatics, Early Dereplication, and
		Natural Products

		Donald Bierer
		Group Leader, Medicinal Chemistry,
		Shaman Pharmaceuticals, Inc.
		Presentation: Integrating Modern Science and
		Traditional Healing in the Drug Discovery Process

		John P. Devlin
		President, MicroBotanica, Inc
		Presentation: Biochemical Prospecting in the Peruvian
		Amazon: A Model of International Collaboration

		Wilhelm Stahl
		Hoechst Marion Roussel
		Presentation: Aspects of Automation in Natural
		Products Screening

1:00 - 4:00:	Informatics
		Session Chair: Jonathan Greene
		Director, Technology Development, CombiChem, Inc.

		Carleton R. Sage
		Principal Scientist, Computational Sciences,
		MetaXen LLC
		Presentation: Beyond Potency and Selectivity:
		Prediction and Optimization of ADME Parameters

		Yvonne Martin
		Senior Project Leader, CAMD Project,
		Abbott Laboratories
		Presentation: Better and Better Strategies for Diversity
		Selection ... An Update on Abbott Work

		Webb Andrews
		Research Investigator,
		Glaxo Wellcome Research Institute
		Presentation: Use of Constrained Properties as a
		Basis for the Construction of Combinatorial Libraries

7:00 PM: 	Tapas Party - Sponsored by Network Science Corporation

Wednesday, March 11

8:30 - 11:30:	Gene-Based Drug Design
		Session Chair: Susan Burgess
		Vice President, Structural Bioinformatics, Inc.

		Leigh Anderson
		President and CSO, Large Scale Biology Corporation
		Presentation: Pharmaceutical Proteomics:
		Characterization of Disease Processes and Drug
		Mechanisms Through Gene Expression Effects

		Donald N. Halbert
		Director, Genomics and Molecular Biology,
		Abbott Laboratories
		Presentation: Genomics-Based Target Discovery:
		Expectations and Reality

		Rick Fine
		Chief Scientific Officer, Paradygm Technologies
		Presentation: Protein Surface-Feature Databases: An
		Approach to Understanding, Quantitating, and
		Comparing Proteins Within and Across Families

Accommodations

The Wild Dunes conference center, located near historic Charleston South
Carolina, offers a variety of activities including 2 1/2 miles of private
beach,
two world class golf courses, several tennis courts, and a heated pool. For
additional information about Wild Dunes, please visit their Website
(http://www.wilddunes.com). Housing will be available beginning Saturday,
March 7. To facilitate a lively exchange of ideas with colleagues in a casual
setting, attendance at this meeting will be limited.

Other Information

Payments: The conference registration fee is $895 ($695, academic)
which includes all breakfasts, lunches, refreshments, Sunday reception,
Monday evening's dinner, and Tuesday's tapas party. Payments should
be in the form of personal or company check made payable to Network
Science Corporation (EIN: 57-1038302).

About Network Science

Network Science Corporation, a registered non-profit (501(c)3)
organization, was founded in 1995 to assist in science education
and career development within the pharmaceutical and biotechnology
industries. Over the past two years, Network Science, in conjunction
with a number of scientists from the chemical industry, has created
a World-Wide Web site (http://www.netsci.org) which contains
resources dedicated to educational and professional development.
By carefully monitoring trends within the pharmaceutical industry,
Network Science is positioned to organize and present targeted
meetings which address topics of current interest to professionals
within the industry. In addition, the company researches and publishes
industry-wide surveys on topics such as spending and staffing trends,
resource allocation, and technology development.

Call For Poster Session Abstracts

Attendees who wish to present a paper in the Poster Session should
submit an abstract for approval by the Conference Organizing
Committee. The presenter for the poster must be listed as its first
author in the abstract, and each attendee is limited to one presentation
in the Poster Session. Abstracts should be limited to one page,
twelve point font and must contain:

	* The title of the presentation
	* The names, affiliations, and full contact information for
	   each of the authors
	* The abstract. If structures are part of the abstract, please
	   submit them separately as a ChemDraw or ISIS Draw
	   formatted file.

Please note: Only 10 posters will be accepted for presentation at this
conference.  If you would like to receive additional details about the
meeting, please contact us at the address below.

The 1998 Charleston Conference
Registration Form
Meeting and Housing

Please Note: This form will reserve your space at the Charleston
Conference. In order to guarantee your reservation, send your payment
and registration form to Network Science at:

Network Science Corporation
412 Carolina Blvd.
Isle of Palms, SC 29451
Tel: (803)886-8775; Fax: (803)886-5924; E-mail: [email-masked]

Name:
Title:
Department:
Company:
Address:
City:		State:	Code:		Country:
Phone:  		Fax:  			Home Phone:
E-mail address:
Arrival Date (check in 4:00 p.m.)
Departure Date (check out 11:00 a.m.)
Do you need shuttle service from the airport to
Wild Dunes (Fee: $35.00):
Arrival Time:
Number of people in your party:
Dietary Restrictions:
Registration fee:   Commercial ($895)      Academic ($695)

Please note: All accommodations require a three night minimum
stay. A deposit equal to one night's stay ($89/$109) is due with
registration to secure your room reservation. All reservations should
be made as early as possible in order to guarantee specific
accommodations and group rates. Your advance deposit will be
applied to your account or will be returned with 14 days notice
should cancellation be necessary. Should you cancel less than
30 days before arrival, or fail to cancel a reservation, your one
night's deposit will be forfeited.  Please note that Wild Dunes is
comprised of privately owned villas; therefore, bedding arrangements
are not standardized as in hotels. Boardwalk suites are comprised
of three or four bedrooms. If you wish to share a suite with colleagues,
please include their names and affiliations.