Subject: Summary Orally Available Compounds

From: [email-masked] (Peter Grootenhuis)
Date: Tue, 20 Apr 1999 17:21:16 -0700

My question was:
Can anybody point me to databases or lists or websites with data on oral

bioavailability of compounds ? Also intestinal absorption, metabolic
stability or toxicity data would be of interest.

Summary of answers:
(1) from Emilio Benfenati (e-mail: [email-masked]):
A list of web sites, including some on toxicological data, is available
at
the site http://www.elet.polimi.it/AAAI-PT
Most of them have been suggested by A. Richard, USEPA.
In particular, there is the data base ECDIN, which  includes data on a
wide
number of chemicals.
(2) from Jens Sadowski (e-mail: [email-masked]):
Lipinski at Pfizer proposed to use simply the subset of the World Drug
Index
(Derwent) that has got a USAN name assuming that these are the
successful and
thus implicitly bioavailable compounds.....
(3) from Carlos Faerman (e-mail: [email-masked]):
I can suggest that you look at METABOLITE, a database that has different

metabolic pathways and which also allows you to find possible
metabolites
for your lead molecule. METABOLITE is licensed by MDL.
(4) from William Jorgensen (e-mail: [email-masked]):
The FDA gives dosage & administration info on all approved drugs:
www.fda.gov

Thanks everybody ! I am still  interested in more info ....
--
Dr. Peter D.J. Grootenhuis - Director Molecular Design
CombiChem, Inc. - 9050 Camino Santa Fe - San Diego CA 92121
Tel: +1(619)530-0484 ext 168, Fax: +1(619)530-9998
[email-masked] - http://www.combichem.com