Subject: t-state for peptide hydrolysis

From: "David Anick" <[email-masked]>
Date: Fri, 17 Sep 1999 21:16:28 -0400

Dear CCL folks,

I am wondering if anyone knows, or knows a reference for, the following.

What does the transition state look like (i.e. computed via an ab initio
method) for the reaction which is the hydrolysis of a peptide bond
(e.g. gly-gly dimer)? And what are the free energies of activation 
(i.e. G(tr state) - = G(reactants) )
at 300K, with and without a proteolytic enzyme?

As usual, I will post all replies in a follow-up mailing.

Thank you,

David Anick MD PhD
[email-masked]