Subject: cis/trans rotation barrier in peptides?

From: "Ed E. Moret" <[email-masked]>
Date: Thu, 25 Nov 1999 11:22:01 +0100

Hi CCL

A question for the force field developers; I hope it is not a faq. It
seems
basic though.

I would like to know what the experimental rotation barrier energy of
the amide 
bond is in peptides of different composition? So, not just the readily
accessible data on cis/trans isomerisation of prolines.

If this is beyond measurement: has it been computed, taking into account
solvation effects?

With best regards
Ed Moret

-- 
| Ed E. Moret	(@more@)	Department of Medicinal Chemistry
| Faculty of Pharmacy	Utrecht University	The Netherlands
| Tel.: +31 30 2536979(2536958)	Fax: +31 30 2536655 
| E-mail: [email-masked]	WWW: http://wwwcmc.pharm.uu.nl/moret/