Subject: Examples for late drug candidate failures due to ADME

From: "Osman F. Guner" <[email-masked]>
Date: Mon, 15 May 2000 13:18:42 -0700

Are there any famed examples of late failures of drug candidates (or
drugs)?  Any additional information and/or references related to the cost
associated with those failures will also be useful.  This is for a
preliminary research on a potential symposium.  I will be happy to
summarize the responses to the list.

Thx...Osman
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Osman F. Güner, Ph.D.
Director,  Lead Identification & Optimization
Molecular Simulations Inc.   (858) 799-5341
[email-masked]        http://www.msi.com