Subject: Re: CCL:prions

From: Yun Tang <[email-masked]>
Date: Fri, 09 Feb 2001 10:22:27 -0500

Iraj Daizadeh wrote:
> 
> Dear CCL.
> 
> I was wondering what computational work
> has been performed in prions. A project
> on this is of most relevance due to the
> mad cow follies...
> 
> Any thoughts?
> 
> Thanks, Iraj.
> 

Hi, as I know, there are a couple of molecular dynamics simulations done
on prion protein:

   Billeter M, Wuthrich K
     The prion protein globular domain and disease-related mutants
studied by molecular dynamics simulations
     ARCH VIROL 251-263 Suppl. 16 2000 

   Zuegg J, Gready JE
     Molecular dynamics simulation of human prion protein including both
N-linked oligosaccharides and the GPI anchor
     GLYCOBIOLOGY 10: (10) 959-974 OCT 2000 

   Zuegg J, Greedy JE
     Molecular dynamics simulations of human prion protein: Importance
of correct treatment of electrostatic interactions
     BIOCHEMISTRY-US 38: (42) 13862-13876 OCT 19 1999 

Hope helpful,

Yun
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Dr. Yun TANG
Laboratory of Medicinal Chemistry
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