Subject: how to calculate the covalent binding energy?

From: bxiong <[email-masked]>
Date: Mon, 4 Jun 2001 11:6:52 +0800

hello all members:
I need your help!!!
When I want to calculate the binding energy of the protein and ligand,I find my ligand  covalently combined with the protein. how can we tackle this problem? Does any one know the 
empirical method to calculate it?any reference or answers will be helpful!
thanks again !!

Best regards!
   
            [email-masked]

Xiong Bin  
Shanghai Institute of Materia Medica, C.A.S.
phone:021-64311833-222(office)