From chemistry-request@server.ccl.net Sat Feb 2 05:27:02 2002 Received: from web21303.mail.yahoo.com ([216.136.129.192]) by server.ccl.net (8.11.6/8.11.0) with SMTP id g12AR2c27978 for ; Sat, 2 Feb 2002 05:27:02 -0500 Message-ID: <20020202102654.56577.qmail@web21303.mail.yahoo.com> Received: from [208.241.25.130] by web21303.mail.yahoo.com via HTTP; Sat, 02 Feb 2002 02:26:54 PST Date: Sat, 2 Feb 2002 02:26:54 -0800 (PST) From: Richard SMITH Subject: qsar IC50 To: chemistry@ccl.net MIME-Version: 1.0 Content-Type: text/plain; charset=us-ascii Dear Friends: I am trying to build QSAR using 17 compounds for which IC50 values are available. Do I need to use the IC50 as it is or should I take log(IC50) or -log(IC50). The values range from 10 to 100. I tried IC50 and log(IC50) using GFA. I am getting different QSAR equation. Could you please advice me on how to proceed. Thanks in advance. Smith __________________________________________________ Do You Yahoo!? Great stuff seeking new owners in Yahoo! Auctions! http://auctions.yahoo.com From chemistry-request@server.ccl.net Sat Feb 2 14:00:52 2002 Received: from web20605.mail.yahoo.com ([216.136.226.163]) by server.ccl.net (8.11.6/8.11.0) with SMTP id g12J0qc05908 for ; Sat, 2 Feb 2002 14:00:52 -0500 Message-ID: <20020202190044.86537.qmail@web20605.mail.yahoo.com> Received: from [64.130.222.245] by web20605.mail.yahoo.com via HTTP; Sat, 02 Feb 2002 11:00:44 PST Date: Sat, 2 Feb 2002 11:00:44 -0800 (PST) From: Sengen Sun Subject: Re: Mechanism of concerted cycloadditions To: chemistry@ccl.net MIME-Version: 1.0 Content-Type: text/plain; charset=us-ascii Since I posted my second preprint paper (see my message in this list on Jan. 13, 02), the paper has been downloaded 664 times for the last four weeks. The interesting thing I noticed is the ranking. The average number of stars changed from 4, 3, 2, 3, 2, 3, and is currently 3. That means half of the people gave me marks of 4 or 5, and the other half gave 1 or 2. The critical issue is whether the electron flow is controlled by the force fields of reactants or some kind of wave functions. It is clear that a consensus has not been reached on this issue. I am very interested any feedback and I have not received any so far. As asked by a couple of people, I can forward the paper to any one who doesn’t want to access the Preprint Server. Let me know by sending me an e-mail. Thanks for attention. Sengen __________________________________________________ Do You Yahoo!? Great stuff seeking new owners in Yahoo! Auctions! http://auctions.yahoo.com