From chemistry-request@server.ccl.net Mon Apr 22 01:16:46 2002 Received: from mailf.telia.com ([194.22.194.25]) by server.ccl.net (8.11.6/8.11.0) with ESMTP id g3M5GjA07872 for ; Mon, 22 Apr 2002 01:16:46 -0400 Received: from d1o916.telia.com (d1o916.telia.com [213.65.164.241]) by mailf.telia.com (8.11.6/8.11.6) with ESMTP id g3M5GWY25508; Mon, 22 Apr 2002 07:16:36 +0200 (CEST) Received: from [192.168.0.100] (h78n2fls32o916.telia.com [213.67.37.78]) by d1o916.telia.com (8.10.2/8.10.1) with ESMTP id g3M5GXi23863; Mon, 22 Apr 2002 07:16:33 +0200 (CEST) Mime-Version: 1.0 X-Sender: u42123287@m1.421.telia.com Message-Id: In-Reply-To: References: Date: Mon, 22 Apr 2002 07:16:46 +0200 To: Yunfeng Hu From: Per-Ola Norrby Subject: Re: CCL:programs to extract md needed force constants from g98 calculation Cc: chemistry@ccl.net Content-Type: text/plain; charset="us-ascii" ; format="flowed" Hi, >I'm trying to write a force parameter file for a inhibitor with sulfite >substituents. Since the major force fields do not have them, I use g98 to >generate the force constants. I wonder if there are any softwares that >can change g98 output into the md format force constants. Thanks! Not completely straightforward, has to be done in a way that is compatible with the existing parts of the force field. Have a look at: "Automated Molecular Mechanics Parameterization with Simultaneous Utilization of Experimental and Quantum Chemical Data" Per-Ola Norrby and Tommy Liljefors, J. Comput. Chem. 1998, 19, 1146-1166 "Deriving Force Field Parameters for Coordination Complexes" Per-Ola Norrby and Peter Brandt, Coord. Chem. Rev. 2001, 212, 79-109 "Recipe for an organometallic force field" Per-Ola Norrby, in Computational Organometallic Chemistry, Ed: T. Cundari; Marcel Dekker: New York, 2001, 7-37 There are also numerous citations in these (in particular in the CCR review), to work dealing with general force field parameterization, by Hagler, Halgren, Rasmussen, Allinger, Dillen, ... Regards, Per-Ola -- ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ Per-Ola Norrby, Assoc. Professor, http://compchem.dfh.dk/PeO/ Technical University of Denmark, Dept. of Chem., Org. Chem. Building 201, Kemitorvet, DK-2800 Kgs. Lyngby, Denmark Email: pon@kemi.dtu.dk tel +45-45252123, fax +45-45933968 From chemistry-request@server.ccl.net Mon Apr 22 04:45:04 2002 Received: from albert.unito.it ([130.192.119.1]) by server.ccl.net (8.11.6/8.11.0) with ESMTP id g3M8j4A10747 for ; Mon, 22 Apr 2002 04:45:04 -0400 Received: (from root@localhost) by albert.unito.it (8.12.2/8.12.2) id g3M8itC0018821 for chemistry@ccl.net; Mon, 22 Apr 2002 10:44:55 +0200 Received: from unito.it (fpc24.pharm.unito.it [130.192.116.24]) by albert.unito.it (8.12.2/8.12.2) with ESMTP id g3M8itT8018780 for ; Mon, 22 Apr 2002 10:44:55 +0200 Message-ID: <3CC3CDE9.222C9FFB@unito.it> Date: Mon, 22 Apr 2002 10:46:33 +0200 From: Giuseppe Ermondi X-Mailer: Mozilla 4.78 [en] (Windows NT 5.0; U) X-Accept-Language: en MIME-Version: 1.0 To: chemistry@ccl.net Subject: SUMMARY: Cahrge and Force Field Parametrization X-scanner: scanned by Inflex 1.0.9 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit Hi CCL, first of all I would like to thank CCL and the person who wrote me very interesting answers to my question. I apologize with Jerome because I did not forward him the messages but I hope that this summary was usefull! Thank to David, I think that the references that you suggested me is sufficiente for my proposal. Thanks to Sergio, I think that the reference that you named was: Automatic parameterization of force field by systematic search and genetic algorithms Wang JM, Kollman PA JOURNAL OF COMPUTATIONAL CHEMISTRY 22 (12): 1219-1228 SEP 2001 Finally thank to Vlad who suggested me a good web site with usefull information. Now the summary! Best regards, Giuseppe ============================================================ Original question: ----------------- Hi CCL, I am working with Autodock and GROMACS and I am looking for articles, reviews or other material regarding two subjects: 1) how can evaluate charge distribution for molecules or groups like heme in order to obtain reasonable charges (coherent with "classical" sets like Amber or Kollman charges)? Are there any compilations of charges for uncommon groups? 2) how can obtain reasonable parametrization for the same groups? Are there databases available for the more usefull programs? Thank you Regards Giuseppe Ermondi ================================================================ ================================================================ Jerome wrote: -------------- Hi Giuseppe I would appreciate if you could forward me answers you get on your question. CHARMM parameters and topology for for Ferrous (Fe2+) heme can be found at the following URL: http://www.pharmacy.umaryland.edu/faculty/amackere/research.html look at: par_all27_prot_lipid.inp top_all27_prot_lipid.inp I am looking for parameters for Ferric (Fe3+) heme for use with CHARMM. If you ever have information about that, I'd be glad to know... Ciao, Jerome ---------------------------------------------------------- Jerome Baudry, Ph.D. Computational Research Scientist, Research Coordinator 150 Noyes Lab. Computer Applications & Network Services School of Chemical Sciences University of Illinois at Urbana-Champaign 505 S. Mathews Ave.; Box 2.1; Urbana, IL, 61801 Phone: (1) (217) 244 3210; Fax: (1) (217) 333 3210; E-mail: jerome@scs.uiuc.edu ============================================================ David wrote: ------------- Giuseppe, For groups like heme, and other common cofactors, it is most likely that complete parameters exist - I know that heme is part of the standard CHARMM protein parameter sets, and I expect that AMBER parameters exist for it as well. I'm not sure where to look for these, but if you look around on the AMBER site: http://www.amber.ucsf.edu/amber/, you should be able to find some direction. For less common molecules, and virtually all drugs, you'll most likely have to come up with your own charges - and possibly other parameters. Associated with the AMBER package is a program RESP - which I believe can be obtained separately and for free - which fits partial atomic charges to an electrostatic potential obtained from QM calculations. This is, I believe, the method of choice for obtaining new charges for use in AMBER. I've appended BibTex entries for the two papers describing RESP, and a few links you might like to check out are http://www.amber.ucsf.edu/amber/charges.txt , which is a describing of the charge fitting philosophy of the Kollman group written by Wendy Cornell, and http://www.amber.ucsf.edu/amber/Questions/resp.html , which has some FAQs about RESP. Of course there are many other methods for obtaining charges, some based of fitting the QM ESP, others based on empirical methods, but I focussed on RESP here since you seem to be using the Kollman group force fields. If you want more info about some of the other methods, just let me know and I'd be glad to send you a bigger list of references. @Article{resp1, author = {Bayly, C. I. and Cieplak, P. and Cornell, W. D. and Kollman, P. A.}, title = {A well-behaved electrostatic potential based method using charge restraints for determining atom-centered charges: The {RESP} model}, journal = jpc, year = 1993, volume = 97, pages = {10269-10280}, group = {Kollman} } @Article{resp2, author = {Cornell, W. D. and Cieplak, P. and Bayly, C. I. and Kollman, P. A.}, title = {Application of {RESP} charges to calculate conformational energies, hydrogen bond energies, and free energies of solvation}, journal = jacs, year = 1993, volume = 115, pages = {9620}, group = {Kollman} } Hope this helps! David -- ------------------------------------------- David F. Green Department of Chemistry Massachusetts Institute of Technology 77 Massachusetts Ave., Rm. 6-133 Cambridge, MA 01239 Phone: 617-258-6229 Fax: 617-253-7030 Email: dfgreen@lms.mit.edu ------------------------------------------- ====================================================== Vlad wrote: ------------ Take a look at the AMBER data base on the web...As far as I remember there are parameters there for heme. vlad ======================================================= Sergio wrote, ------------- Dear Giuseppe, The best way to obtain relaible charges is to use ESP charges (MK or CHELPG) calculated by quantum mechanical method (HF/6-31G(d) for example). For AMBER force field the best is to calculate charges by RESP method.n There some programs to parametrize stretchings, bendings and torsional terms in a force field. I use PAPQMD developed by F.J. Luque, M. Orozco and C. Aleman, in Barcelona (http://www.bq.ub.es/recmol/soft.html), but in J. Comp. Chem., , 2001 there is a paper from Kollman that presents a new method for parameterization (sorry I don't find it ). Hope this help, Sergio ============================================================== Sergio Emanuel Galembeck Assistant Professor in Physical Chemistry Laboratorio de Modelagem Molecular Departamento de Quimica Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto Universidade de Sao Paulo Av Bandeirantes, 3900 Ribeirao Preto, SP Brasil phone: +55-16-602-37-65 fax: +55-16-633-81-51 e-mail: segalemb@usp.br ============================================================== _____________________________________________________________________ For your security, this mail has been scanned and protected by Inflex From chemistry-request@server.ccl.net Mon Apr 22 05:32:36 2002 Received: from ribotargets.com ([194.129.39.11]) by server.ccl.net (8.11.6/8.11.0) with ESMTP id g3M9WZA11355 for ; Mon, 22 Apr 2002 05:32:36 -0400 Received: from szilva (helo=localhost) by echo.ribotargets.com with local-esmtp (Exim 3.13 #1) id 16za8C-00079t-00; Mon, 22 Apr 2002 09:29:08 +0000 Date: Mon, 22 Apr 2002 09:29:08 +0000 (GMT) From: Szilveszter Juhos To: song yunlong cc: chemistry@ccl.net Subject: Re: CCL:solutions about how to execute the InsightII software from a PC desktop In-Reply-To: Message-ID: MIME-Version: 1.0 Content-Type: TEXT/PLAIN; charset=US-ASCII On Sun, 21 Apr 2002, song yunlong wrote: > Can you kindly provide me some solutions about how to execute the > InsightII software from a PC desktop. Hello, if you browse through the CCL archive you will be able to find a quite long discussion about it. Apparently it is not solved yet, you have to have an SGI or on a remote X display run insightII -nosplash -opengl #never worked for me or insightII -nosplash -axxess #not that good quality Szilva From chemistry-request@server.ccl.net Mon Apr 22 08:28:50 2002 Received: from mail-mta3.service.ohio-state.edu ([128.146.216.43]) by server.ccl.net (8.11.6/8.11.0) with ESMTP id g3MCSoA13414 for ; Mon, 22 Apr 2002 08:28:50 -0400 Received: from osu.edu (laba-pc22.pharmacy.ohio-state.edu [128.146.80.238]) by mail-mta3.service.ohio-state.edu (iPlanet Messaging Server 5.1 (built May 7 2001)) with ESMTP id <0GUY00GCBYNNJ7@mail-mta3.service.ohio-state.edu> for chemistry@ccl.net; Mon, 22 Apr 2002 08:28:35 -0400 (EDT) Date: Mon, 22 Apr 2002 08:28:34 -0400 From: Praveen M Bahadduri Subject: Autodock3 Sender: praveen@osu.edu To: chemistry@ccl.net Message-id: <3CC401F2.80580FBE@osu.edu> MIME-version: 1.0 X-Mailer: Mozilla 4.7C-SGI [en] (X11; I; IRIX 6.5 IP32) Content-type: text/plain; charset=us-ascii Content-transfer-encoding: 7BIT X-Accept-Language: en, marathi, Mr References: Hi! CCL, I am working with autodock for some time. I had a recurring problem. I am reposting this question. When I run autodock program and read the docked pdb file in sybyl window, I get a bunch of straight lines with dots. I cannot figure out if there is any specific arrangement of these lines or dot. I carried it several times, but in vain. Can anybody please let me know solution to this problem? Sincerely Praveen The Ohio-State University Columbus, OH. From chemistry-request@server.ccl.net Mon Apr 22 10:49:41 2002 Received: from access.etsu.edu ([151.141.99.22]) by server.ccl.net (8.11.6/8.11.0) with ESMTP id g3MEnfA17052 for ; Mon, 22 Apr 2002 10:49:41 -0400 Received: from dmc ([151.141.29.51]) by ACCESS.ETSU.EDU (PMDF V6.1 #39282) with SMTP id <01KGV0XMHA70A0UCVL@ACCESS.ETSU.EDU> for chemistry@ccl.net; Mon, 22 Apr 2002 10:49:11 -0400 (EDT) Date: Mon, 22 Apr 2002 10:50:01 -0400 From: David Close Subject: G98 memory or disk size? X-Sender: closed@access.etsu.edu To: chemistry@ccl.net Message-id: <3.0.6.32.20020422105001.009e0940@access.etsu.edu> MIME-version: 1.0 X-Mailer: QUALCOMM Windows Eudora Light Version 3.0.6 (32) Content-type: text/plain; charset=us-ascii Content-transfer-encoding: 7BIT CCLers: I am trying some problems that use lots of memory and disk space. In particular an ROVGF calculation on cytosine to determine the IP. My computer runs out of disk space when writing the integrals to an .rwf file. Some friends have said to split this file into segments using %rwf=a,1989mb,b,1989mb,c,1989mb, etc. This actually works for a few more minutes. i.e. the problems continues execution but eventually crashes. Looking at the scratch files I note that a.rwf is pretty big, and b.rwf is gigantic. But nothing is written in c.rwf, etc. So I presume I have again run out of disk space? But this time I have no warning, just a core dump and a failed execution. Any hints on what to try next? Regards, Dave Close. From chemistry-request@server.ccl.net Mon Apr 22 22:02:49 2002 Received: from schrodinger.com ([192.156.98.99]) by server.ccl.net (8.11.6/8.11.0) with ESMTP id g3N22nA27080 for ; Mon, 22 Apr 2002 22:02:49 -0400 Received: from florence.schrodinger.com ([216.216.237.111]) by schrodinger.com (8.8.5/8.8.5) with ESMTP id TAA04916 for ; Mon, 22 Apr 2002 19:02:34 -0700 Received: from localhost (ramy@localhost) by florence.schrodinger.com (8.11.2/8.8.5) with ESMTP id g3N22JG06182 for ; Mon, 22 Apr 2002 22:02:19 -0400 X-Authentication-Warning: florence.schrodinger.com: ramy owned process doing -bs Date: Mon, 22 Apr 2002 22:02:19 -0400 (EDT) From: Ramy Farid To: chemistry@ccl.net Subject: CCL: Homology modeling survey! Message-ID: MIME-Version: 1.0 Content-Type: TEXT/PLAIN; charset=US-ASCII We are conducting a survey of people who use homology modeling software, in order to understand their needs and interests. If you use homology software, please take a few moments to visit our web site and fill out the survey, at: http://www.schrodinger.com/Surveys/HMSurvey.htm One lucky respondent will receive a brand new Palm m515! Thanks for your input, and good luck in the drawing!! From chemistry-request@server.ccl.net Mon Apr 22 22:19:12 2002 Received: from mtiwmhc22.worldnet.att.net ([204.127.131.47]) by server.ccl.net (8.11.6/8.11.0) with ESMTP id g3N2JBA27247 for ; Mon, 22 Apr 2002 22:19:11 -0400 Received: from webmail.worldnet.att.net ([204.127.135.30]) by mtiwmhc22.worldnet.att.net (InterMail vM.4.01.03.27 201-229-121-127-20010626) with SMTP id <20020423021857.UQZE28991.mtiwmhc22.worldnet.att.net@webmail.worldnet.att.net>; Tue, 23 Apr 2002 02:18:57 +0000 Received: from [138.23.156.82] by webmail.worldnet.att.net; Tue, 23 Apr 2002 02:18:56 +0000 From: dkeidel397@att.net To: chemistry@ccl.net Subject: convergence failure Date: Tue, 23 Apr 2002 02:18:56 +0000 X-Mailer: AT&T Message Center Version 1 (Mar 27 2002) Message-Id: <20020423021857.UQZE28991.mtiwmhc22.worldnet.att.net@webmail.worldnet.att.net> Hello all, I am new to the gaussian98 (and Gaussian in general) so I hope that this question is not remedial. I am running my first calculation and I recieve the following error: >>>>>>>>>> Convergence criterion not met. SCF Done: E(RHF) = -2466.88014462 A.U. after 65 cycles Convg = 0.1379D-03 -V/T = 2.0051 S**2 = 0.0000 KE= 2.454261151979D+03 PE=-8.251028945559D+03 EE= 2.134018806627D+03 Convergence failure -- run terminated. Error termination via Lnk1e in /usr/local/g98/l502.exe. I tried to add the line: Opt=(MaxCycle=30) since someone here told me to try that, but I do not think that will solve my problem. I would greatly appreciate any help in this manner. Thank you in advance and have a great day. I have pasted my input file below. #P HF/STO-3G pop=(chelpg, readrad) density=current Opt=MaxCycle=400 HF/STO-3G//HF/STO-3G 0 1 C 1 r2 C 2 r3 1 a3 C 3 r4 2 a4 1 d4 C 4 r5 3 a5 2 d5 C 1 r6 2 a6 3 d6 C 4 r7 3 a7 2 d7 C 7 r8 4 a8 3 d8 C 8 r9 7 a9 4 d9 C 5 r10 4 a10 3 d10 C 9 r11 8 a11 7 d11 O 11 r12 9 a12 8 d12 O 11 r13 9 a13 8 d13 C 2 r14 1 a14 3 d14 O 14 r15 2 a15 1 d15 O 14 r16 2 a16 1 d16 Zn 12 r17 11 a17 9 d17 H 1 r18 2 a18 3 d18 H 3 r19 2 a19 1 d19 H 6 r20 1 a20 2 d20 H 7 r21 4 a21 3 d21 H 8 r22 7 a22 4 d22 H 10 r23 5 a23 4 d23 Variables: r2= 1.4192 r3= 1.3871 a3= 119.97 r4= 1.4055 a4= 120.68 d4= 0.03 r5= 1.4353 a5= 119.38 d5= 359.96 r6= 1.3713 a6= 120.80 d6= 359.97 r7= 1.4294 a7= 121.89 d7= 179.97 r8= 1.3639 a8= 121.33 d8= 179.97 r9= 1.4318 a9= 119.91 d9= 359.97 r10= 1.3982 a10= 119.60 d10= 180.03 r11= 1.4173 a11= 119.91 d11= 179.97 r12= 1.3318 a12= 125.08 d12= 0.03 r13= 1.3328 a13= 124.98 d13= 179.97 r14= 1.5382 a14= 119.45 d14= 180.03 r15= 1.2565 a15= 116.60 d15= 180.66 r16= 1.2569 a16= 116.42 d16= 0.71 r17= 2.0197 a17= 92.37 d17= 179.88 r18= 1.1058 a18= 116.95 d18= 179.97 r19= 1.1037 a19= 118.39 d19= 179.92 r20= 1.0995 a20= 121.18 d20= 179.97 r21= 1.1028 a21= 117.89 d21= 359.88 r22= 1.1009 a22= 121.65 d22= 179.97 r23= 1.1040 a23= 119.82 d23= 180.03 Thanks, Don -- Donald J. Keidel University of California, Riverside Department of Biochemistry and Molecular Biology Riverside, CA 92521 phone: (909) 787-5493 fax: (909) 787-4434 dkeidel397@att.net From chemistry-request@server.ccl.net Mon Apr 22 16:53:01 2002 Received: from neptune.neokimia.com ([132.210.158.200]) by server.ccl.net (8.11.6/8.11.0) with ESMTP id g3MKr1A23847 for ; Mon, 22 Apr 2002 16:53:01 -0400 Received: (from root@localhost) by neptune.neokimia.com (8.11.2/8.11.2) id g3MKqqu19808 for ; Mon, 22 Apr 2002 16:52:52 -0400 Received: from exchange.neokimia.com (mail-exg.neokimia.com [192.168.1.3]) by neptune.neokimia.com (8.11.2/8.11.2) with ESMTP id g3MKqps19677 for ; Mon, 22 Apr 2002 16:52:51 -0400 content-class: urn:content-classes:message Subject: Comp Chem Courses ... complete undergrad program! MIME-Version: 1.0 Content-Type: multipart/alternative; boundary="----_=_NextPart_001_01C1EA3F.A17844DC" Date: Mon, 22 Apr 2002 16:52:35 -0400 X-MimeOLE: Produced By Microsoft Exchange V6.0.4712.0 Message-ID: X-MS-Has-Attach: X-MS-TNEF-Correlator: Thread-Topic: Comp Chem Courses ... complete undergrad program! Thread-Index: AcHqP6ty3OwzEaF7RiKPoWIiKCnT6g== From: "Axel Mathieu" To: X-AntiVirus: scanned for viruses by AMaViS 0.2.1 (http://amavis.org/) This is a multi-part message in MIME format. ------_=_NextPart_001_01C1EA3F.A17844DC Content-Type: text/plain; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Hello everybody ... =20 Sorry for this late reply but I just got back from the Structure-Based Drug Design conference in Boston ... Over there, I met two teachers from University of New Brunswick (that's right ... in Canada!) that offer what seems to be a complete undergraduate program in computational chemistry. This program consists of both chemistry and "computer" courses and the program is now on the 2nd year of the first group (as I understand it). What makes it interesting is that the computational chemistry course has been set up in interactive FLASH, and the students have access to all the files in order to make their learning easier. I haven't really checked out their web page but maybe you can find something at www.unb.ca ... good luck! =20 Axel Mathieu, Ph.D. Computational Chemist NEOKIMIA INC. www.neokimia.com =20 =20 =20 ------_=_NextPart_001_01C1EA3F.A17844DC Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Message
Hello = everybody=20 ...
 
Sorry = for this late=20 reply but I just got back from the Structure-Based Drug Design = conference=20 in Boston ... Over there, I met two teachers from University of New = Brunswick (that's right ... in Canada!) that offer what seems to be a = complete=20 undergraduate program in computational chemistry. This program consists = of both=20 chemistry and "computer" courses and the program is now on the 2nd year = of the=20 first group (as I understand it). What makes it interesting is that the=20 computational chemistry course has been set up in interactive FLASH, and = the=20 students have access to all the files in order to make their learning = easier. I=20 haven't really checked out their web page but maybe you can find = something at www.unb.ca ... good = luck!
 
Axel Mathieu, = Ph.D.
Computational Chemist
NEOKIMIA INC.
www.neokimia.com
 
 
------_=_NextPart_001_01C1EA3F.A17844DC-- From chemistry-request@server.ccl.net Mon Apr 22 18:57:56 2002 Received: from mta7.pltn13.pbi.net ([64.164.98.8]) by server.ccl.net (8.11.6/8.11.0) with ESMTP id g3MMvuA25342 for ; Mon, 22 Apr 2002 18:57:56 -0400 Received: from blackboxw2000 ([64.165.19.43]) by mta7.pltn13.pbi.net (iPlanet Messaging Server 5.1 (built May 7 2001)) with SMTP id <0GUZ00IPLRSB1L@mta7.pltn13.pbi.net> for chemistry@ccl.net; Mon, 22 Apr 2002 15:57:49 -0700 (PDT) Date: Mon, 22 Apr 2002 15:59:04 -0700 From: "PR@AeonTechnology.com" Subject: Release of Direct Force Field, Version 1.1.3 To: chemistry@ccl.net Message-id: <016101c1ea51$4d1e0c70$2b13a540@blackboxw2000> MIME-version: 1.0 X-MIMEOLE: Produced By Microsoft MimeOLE V5.00.2919.6700 X-Mailer: Microsoft Outlook Express 5.00.2919.6700 Content-type: text/plain; charset=iso-8859-1 Content-transfer-encoding: 7BIT X-Priority: 3 X-MSMail-priority: Normal Aeon Technology Inc. is pleased to announce the general availability of Direct Force FieldT 1.1.3. Direct Force FieldT is not just another force field. It is an expert system that can be used to automatically create force field parameters from ab initio data. A patent-pending process that helps fit very complex potential energy surfaces efficiently has been implemented in Direct Force FieldT. This technique enables fast and reliable development of force field parameters > from ab initio data. In addition, this product can be used to generate approximated parameters without fitting data or to convert parameters from one force field to another. The result parameters can be used independently or cooperatively with existing force fields by popular simulation engines such as AMBER, CHARMM and DISCOVER. Please visit www.AeonTechnology.com for more information on our company and on the product.