Subject: Release of X-CScore v1.0: New scoring function available

From: "Renxiao Wang" <[email-masked]>
Date: Mon, 07 Oct 2002 17:58:38 -0400

Dear All,

We would like to announce the release of X-CScore v1.0, a program for estimating protein-ligand binding affinites. Basically, X-CScore is a consensus scoring scheme that consists of three individual empirical scoring functions. It makes fast prediction based purely on protein-ligand complex structures and thus will see its major application to molecular docking approaches. The X-CScore algorithm is described in details on J. Comp.-Aided Mol. Des. 2002, 16:11-26.

This program is currently accessible at http://sw16.im.med.umich.edu/software/xtool/. After filling out a user license agreement, you will be able to download the whole X-CScore packet there, including the source codes, user manual, and other supplementary material. This program is written in ANSI C++ and has been tested on UNIX and LINUX platforms.

There is NO CHARGE for obtaining this program, applied to all the users from both industry and academia. If you experience any problem in downloading or using this program, you may contact us directly.

Happy scoring,

Renxiao Wang, Ph.D.
Research Investigator
Department of Internal Medicine
University of Michigan Medical School