From chemistry-request@server.ccl.net Sat Mar 29 01:09:15 2003 Received: from ccl.net ([192.148.249.4]) by server.ccl.net (8.11.6/8.11.0) with ESMTP id h2T69Fg14154 for ; Sat, 29 Mar 2003 01:09:15 -0500 Received: from krakow.ccl.net (krakow.ccl.net [192.148.249.195]) by ccl.net (8.11.6+Sun/8.11.6/OSC 2.1) with ESMTP id h2T69Gt14275; Sat, 29 Mar 2003 01:09:16 -0500 (EST) Date: Sat, 29 Mar 2003 01:09:13 -0500 (EST) From: Jan Labanowski To: chemistry@ccl.net cc: Jan Labanowski Subject: Call for Papers: Predictive ADME/Predictive Toxicology (fwd) Message-ID: MIME-Version: 1.0 Content-Type: MULTIPART/Mixed; TYPE="multipart/alternative"; BOUNDARY=----_NextPart_0947686655 This message is in MIME format. The first part should be readable text, while the remaining parts are likely unreadable without MIME-aware tools. Send mail to mime@docserver.cac.washington.edu for more info. ------_NextPart_0947686655 Content-Type: TEXT/PLAIN; charset=US-ASCII ---------- Forwarded message ---------- Date: Fri, 28 Mar 2003 15:06:53 -0500 From: Jennifer Laakso To: Jkl Subject: Call for Papers: Predictive ADME/Predictive Toxicology FIRST ANNOUNCEMENT AND CALL FOR PAPERS Cambridge Healthtech Institute Presents Predictive ADME November 17-18, 2003 Predictive Toxicology November 19-20, 2003 Improving Lead Selection Through Innovative Thinking Boston Park Plaza | Boston, MA With 50% of drug failures attributed to ADME-Tox issues, it is critical to accurately predict these qualities earlier in the investigation of a lead to assure appropriate attrition from the drug development process. Empirical assays have been the mainstay of evaluating ADME and toxicity, but they suffer from low throughput and difficulty to automate. New techniques and technologies for predicting these qualities must become more accurate and have the ability to be validated against empirical findings. It will then be possible to drop compounds that are most likely to exhibit ADME or tox problems sooner, and provide ways for researchers to arrive at the same conclusions, but in less time. The more attractive compounds can then be put on the development fast-track. These two, 1.5 day, back-to-back meetings will provide a forum for discussion of new techniques, technologies, and strategies that hold promise for improving the selection of potent, on-target leads with fewer negative side-effects, thus saving time and money. Researchers with experience in applying new technologies or techniques are en- couraged to submit a proposal for oral presentation at one of the two meetings. Topics may include, but are not limited to: Correlation of predictive with empirical results Innovative algorithms Modeling and/or profiling Reliable databases-searching, building Building neural networks for predictive ADMET Gene expression analysis Structure-based prediction Combination technologies/techniques Standardization of profiling data format Case studies of empirical assay replacement Combining "-omics" profiling data Novel Descriptors for Compounds Expression profiles to understand mode of toxicity Researchers who would like to be considered for oral presentations, or to display a poster, are encouraged to submit a title and 3-5 sentence summary of your data, suitable for use in the program brochure should your abstract be selected for oral presentation. Please include full contact information for the presenter. Proposals are subject to review by the Scientific Advisory Board. Are there specific topics or speakers in this area that you would like included in this meeting? If so, please send those suggestions along to help give you the information you need to better meet your research goals. To submit proposals on-line: click here Deadline for Submissions: April 11, 2003 For more information, please contact: Elizabeth Lamb, Conference Director, Cambridge Healthtech Institute Fax: 207-493-4573, E-mail: elamb@healthtech.com For sponsorship or exhibitor information, contact: Angela Parsons, email: aparsons@healthtech.com or tel: 617-630-1367. If the above information is not of interest to you, please disregard and we apologize for any inconvenience this may have caused. To be removed from further emails, click here or contact Audrey Morrissey at morrissey@healthtech.com or 617-630-1348. ------_NextPart_0947686655 Content-Type: IMAGE/JPEG; NAME="RED ARROW.JPG" Content-Transfer-Encoding: BASE64 Content-ID: <200303281506536282764> Content-Description: /9j/4AAQSkZJRgABAQEASABIAAD/2wBDAAYEBAQFBAYFBQYJBgUGCQsIBgYICwwKCgsKCgwQDAwM DAwMEAwODxAPDgwTExQUExMcGxsbHCAgICAgICAgICD/2wBDAQcHBw0MDRgQEBgaFREVGiAgICAg ICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICD/wAARCAAZABkDAREA AhEBAxEB/8QAGAAAAgMAAAAAAAAAAAAAAAAAAAYFBwj/xAArEAAABgAEBAUFAAAAAAAAAAAAAQID BAUGESExBxMigRIUIzNxNFFSdbP/xAAaAQEAAgMBAAAAAAAAAAAAAAAABAUCAwYH/8QAKREAAgIB AgMHBQAAAAAAAAAAAAECAwQREiExcQUGFBYyM1FBc4Ghsf/aAAwDAQACEQMRAD8A1SAAAAAABWZ8 caWFfWFTcxHYyYcp6OmY16qDJpw0Eakl1loX2MQ/GJPRnTeWrJ1Rsrae6Kej4c0PdNiKjumOfVTm paNz5aiMy+U7l3EmM1LkUORiW0vSyLiSIzI4ADKWKoE+bjm9ZgxnZTx2MrJthCln7yvx27iksTc3 p8nq2DbGGLW5NJbI8+gw4a4NY/kPIlGaaPLVLy3DJ8vhLWpdzG2vFn0K7M7w4kVt9z8cP2Xvhmps 6urTEsbR23kErPzTyUpVlkReHp3Istz1FnXFpcXqcJmXwtnuhBVr4RKjMiingb6q+/Zyv7KGin69 S17T9Nf24/wbBvKoAAAD/9k= ------_NextPart_0947686655-- From chemistry-request@server.ccl.net Sat Mar 29 05:54:44 2003 Received: from hamlin.cc.boun.edu.tr ([193.140.192.230]) by server.ccl.net (8.11.6/8.11.0) with ESMTP id h2TAsfg30494 for ; Sat, 29 Mar 2003 05:54:43 -0500 Received: by hamlin.cc.boun.edu.tr (Postfix, from userid 2752) id A52651FBA; Sat, 29 Mar 2003 12:50:25 +0200 (EET) Received: from localhost (localhost [127.0.0.1]) by hamlin.cc.boun.edu.tr (Postfix) with ESMTP id 989BA1C0E for ; Sat, 29 Mar 2003 12:50:25 +0200 (EET) Date: Sat, 29 Mar 2003 12:50:25 +0200 (EET) From: Hakan Gunaydin X-Sender: gunaydin@hamlin.cc.boun.edu.tr To: CHEMISTRY@ccl.net Subject: how to define rwf? Message-ID: MIME-Version: 1.0 Content-Type: TEXT/PLAIN; charset=US-ASCII Dear CCL'ers I would like to run CBS-QB3 run on a linux computer. by typing the following line %rwf=./a,1999MB,b,1999MB,c,1999MB,d,1999MB,e,1999MB,f,1999MB,g,1999MB,h,1999MB,i I can only define 9 rwf. But I need more space than that. Is there any other way that I can define more than 9 rwf? Thanks a lot in advance, ----------------------------------------- Hakan Gunaydin Research Assistant ----------------------------------------- Bogazici University Chemistry Department North Campus 34342 Bebek,Istanbul,TURKEY ----------------------------------------- Tel: +90 212 3581540-2379 Fax: +90 212 2872467 -----------------------------------------