From chemistry-request@ccl.net Sat Nov 27 09:10:10 2004 Received: from prserv.net (out1.prserv.net [32.97.166.31]) by server.ccl.net (8.12.8/8.12.8) with ESMTP id iAREA9Bf008692 for ; Sat, 27 Nov 2004 09:10:09 -0500 Message-Id: <200411271410.iAREA9Bf008692/at/server.ccl.net> Received: from reg.prserv.net ([10.254.181.241]) by attglobal.net (out1) with SMTP id <200411271424432010573eqfe>; Sat, 27 Nov 2004 14:24:43 +0000 From: jmmckel/at/attglobal.net To: chemistry/at/ccl.net Subject: Turbomole Redundant Internal Coordinates Date: Sat, 27 Nov 2004 14:24:43 +0000 X-Priority: 3 MIME-Version: 1.0 Content-Type: text/plain Content-Transfer-Encoding: 7bit X-Spam-Status: No, hits=2.0 required=7.5 tests=NO_REAL_NAME,PRIORITY_NO_NAME autolearn=no version=2.61 X-Spam-Checker-Version: SpamAssassin 2.61 (1.212.2.1-2003-12-09-exp) on servernd.ccl.net CCLers, I have been having a great deal of difficulty dealing with fused ring systems such as coumarins and naphthalenes and geometry optimization using delocalized redundant internal coordinates in Turbomole. The coordinates get generated and the following SCF and initial gradient step is fine. Then the program abends, apparently having trouble with the redundant coordinates... I think it is... There are cautionary notes in the documentation about using RIC, but internal coordinates are preferred over cartesians... Any comments/suggestions would be most appreciated... Turbomole is screaming fast when using non-hybrid functionals.. too fast to simply give up on this.. Many thanks! John McKelvey From chemistry-request@ccl.net Sat Nov 27 14:52:27 2004 Received: from mxsf40.cluster1.charter.net (mxsf40.cluster1.charter.net [209.225.28.172]) by server.ccl.net (8.12.8/8.12.8) with ESMTP id iARJqQpf027258 for ; Sat, 27 Nov 2004 14:52:27 -0500 Received: from mxip03.cluster1.charter.net (mxip03a.cluster1.charter.net [209.225.28.133]) by mxsf40.cluster1.charter.net (8.12.11/8.12.11) with ESMTP id iARK704h028405 for ; Sat, 27 Nov 2004 15:07:01 -0500 Received: from res-66-169-65-074.ash.nc.charter.com (HELO [10.0.1.4]) (66.169.65.74) by mxip03.cluster1.charter.net with ESMTP; 27 Nov 2004 15:07:00 -0500 X-Ironport-AV: i="3.87,113,1099285200"; d="scan'208"; a="467280543:sNHT12922308" Mime-Version: 1.0 (Apple Message framework v619) Content-Transfer-Encoding: 7bit Message-Id: Content-Type: text/plain; charset=US-ASCII; format=flowed To: chemistry^at^ccl.net From: "Dr. Noah Allen" Subject: Compilers Needed for AMBER Date: Sat, 27 Nov 2004 15:06:59 -0500 X-Mailer: Apple Mail (2.619) Colleagues: I am trying to compile AMBER to run under Macintosh OS X, but need the xfl90 fortran compiler and the xlc "C" compiler. Does anyone know where I may obtain these? Many thanks in advance, Noah Allen ********************************************************** Noah W. Allen, III, Ph.D. Assistant Professor of Chemistry Department of Chemistry, CPO #2310 University of North Carolina at Asheville Office 208A Rhoades Hall Research Laboratory 211 Rhoades Hall One University Heights Asheville, NC 28804-8511 Phone 828.232.5174 Fax 828.232.5179 Homepage: http://www.theallenlab.org ********************************************************** From chemistry-request@ccl.net Sat Nov 27 03:12:14 2004 Received: from mailhub05.readyhosting.com (mailhub05.readyhosting.com [63.99.213.16]) by server.ccl.net (8.12.8/8.12.8) with ESMTP id iAR8CBSb022139 for ; Sat, 27 Nov 2004 03:12:11 -0500 Received: from VLifeSciences.com (mail018.readyhosting.com [63.99.224.14]) by mailhub05.readyhosting.com (Postfix) with ESMTP id 1F6401D0EF7; Sat, 27 Nov 2004 02:34:15 -0600 (CST) Received: from vlifeserver.vlifesciences.com [61.11.16.130] by VLifeSciences.com with ESMTP (SMTPD32-8.05) id AA61355400FE; Sat, 27 Nov 2004 02:27:13 -0600 Message-Id: <6.1.2.0.1.20041127135323.0250d628)at(mail.vlifesciences.com> X-Sender: sudhirk)at(vlifesciences.com@mail.vlifesciences.com X-Mailer: QUALCOMM Windows Eudora Version 6.1.2.0 Date: Sat, 27 Nov 2004 13:56:37 +0530 To: boyd)at(chem.iupui.edu, "CCL" From: Dr Sudhir Kulkarni Subject: Re: CCL:What software will work? Cc: boyd)at(chem.iupui.edu In-Reply-To: <51222.65.43.84.126.1101312753.squirrel)at(atom.chem.iupui.edu > References: <51222.65.43.84.126.1101312753.squirrel)at(atom.chem.iupui.edu> Mime-Version: 1.0 Content-Type: text/plain; charset="us-ascii"; format=flowed X-Spam-Status: No, hits=2.6 required=7.5 tests=RCVD_IN_DYNABLOCK, RCVD_IN_SORBS autolearn=no version=2.61 X-Spam-Checker-Version: SpamAssassin 2.61 (1.212.2.1-2003-12-09-exp) on servernd.ccl.net Dear Professor Boyd: Our software "Molecular Design Suite (MDS)" has facility to obtain conformations of organic molecules using Monte Carlo method with MMFF force field. Please have a look at http://www.vlifesciences.com/ProdVLifeMDS.htm and register for demo license at http://www.vlifesciences.com/RegisterAtVLife.htm MDS is capable of meeting ALL your requirements. I am sending you more details in a separate mail. Thank you. Sudhir Kulkarni, Ph.D. VLife Sciences Technologies Pvt. Ltd. At 09:42 PM 11/24/2004, boyd)at(chem.iupui.edu wrote: >CCLers, > >We are seeking recommendations on software that can do ALL the following: > >* run Monte Carlo conformational searches on organic molecules with >200-300 atoms. >* use the MMFF force field. >* select which torsional angles are free to rotate and set their step size. >* fix some torsional angles. >* analyze the conformers produced, such as exporting the resulting >torsional angles and energies to a spreadsheet. > >We have tried SYBYL, MacroModel, Spartan, Cerius2, Quanta, and InsightII. >In each case, the software was unable to provide a solution. > >Suggestions? > >Thankful for your giving recommendations, >Don > >Donald B. Boyd, Ph.D. >Department of Chemistry >Indiana University-Purdue University at Indianapolis >E-mail boyd)at(chem.iupui.edu > > >-= This is automatically added to each message by the mailing script =- >To send e-mail to subscribers of CCL put the string CCL: on your Subject: line >and send your message to: CHEMISTRY)at(ccl.net > >Send your subscription/unsubscription requests to: CHEMISTRY-REQUEST)at(ccl.net >HOME Page: http://www.ccl.net | Jobs Page: http://www.ccl.net/jobs > >If your mail is bouncing from CCL.NET domain send it to the maintainer: >Jan Labanowski, jlabanow)at(nd.edu (read about it on CCL Home Page) >-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+-+ > > > > > >--- >[This E-mail scanned for viruses by Declude Virus] --- [This E-mail scanned for viruses by Declude Virus] From chemistry-request@ccl.net Mon Nov 29 10:51:17 2004 Received: from rinka.central.susx.ac.uk (rinka.central.susx.ac.uk [139.184.14.19]) by server.ccl.net (8.12.8/8.12.8) with ESMTP id iATFpGvI007933 for ; Mon, 29 Nov 2004 10:51:16 -0500 Received: from dorothy.mols.susx.ac.uk ([139.184.113.152]) by rinka.central.susx.ac.uk with esmtp (Exim 4.10) id 1CYo2I-0001ZT-00 for chemistry)at(ccl.net; Mon, 29 Nov 2004 16:05:58 +0000 Date: Mon, 29 Nov 2004 16:06:01 +0000 To: chemistry)at(ccl.net Subject: Q:warning in G03 frequency output Message-ID: <710000.1101744361)at(dorothy.mols.susx.ac.uk> Originator-Info: login-token=Mulberry:01VJjYVrv8O7d5yBvDsffAxkvLugtAzn7vt8ZNwQ==; token_authority=support)at(sussex.ac.uk X-Mailer: Mulberry/3.0.3 (Linux/x86) MIME-Version: 1.0 Content-Type: text/plain; charset=us-ascii; format=flowed Content-Transfer-Encoding: 7bit Content-Disposition: inline X-Sussex: true From: Georgina Aitken X-Spam-Status: No, hits=3.0 required=7.5 tests=NO_RDNS2 autolearn=no version=2.61 X-Spam-Checker-Version: SpamAssassin 2.61 (1.212.2.1-2003-12-09-exp) on servernd.ccl.net Dear CCLers, I am a PhD student and have been getting the following warning messages in the thermochemistry section of my Gaussian frequency outputs for various divalent Pb-ligand complexes: "Principal axes and moments of inertia in atomic units: 1 2 3 EIGENVALUES -- 4494.802316560.791727501.25369 X 0.99998 0.00350 0.00560 Y -0.00289 0.99445 -0.10519 Z -0.00593 0.10517 0.99444 This molecule is an asymmetric top. Rotational symmetry number 1. Warning -- assumption of classical behavior for rotation may cause significant error Rotational temperatures (Kelvin) 0.01927 0.01320 0.01155 Rotational constants (GHZ): 0.40152 0.27508 0.24059 Zero-point vibrational energy 647177.6 (Joules/Mol) 154.67917 (Kcal/Mol) Warning -- explicit consideration of 23 degrees of freedom as vibrations may cause significant error " Does this mean that the zero point energy correction is not reliable? What can I do about it? Thanks in advance, Georgina Aitken From chemistry-request@ccl.net Mon Nov 29 12:49:09 2004 Received: from sandmail01.sd.accelrys.com (rrcs-67-52-158-62.west.biz.rr.com [67.52.158.62]) by server.ccl.net (8.12.8/8.12.8) with ESMTP id iATHn8VD013323 for ; Mon, 29 Nov 2004 12:49:09 -0500 Importance: Normal X-Priority: 3 (Normal) Expiry-Date: Reply-To: training~at~accelrys.com To: CHEMISTRY~at~ccl.net Subject: CCL: Accelrys Customer Training in January MIME-Version: 1.0 Sensitivity: X-Mailer: Lotus Notes Release 6.5.1 January 21, 2004 Message-ID: From: Jeff Nauss Date: Mon, 29 Nov 2004 10:03:43 -0800 X-MIMETrack: Serialize by Router on sandmail01/Server/Accelrys(Release 6.5.2|June 01, 2004) at 11/29/2004 10:03:52 AM, Serialize complete at 11/29/2004 10:03:52 AM Content-Type: text/plain; charset="US-ASCII" X-Spam-Status: No, hits=0.0 required=7.5 tests=none autolearn=no version=2.61 X-Spam-Checker-Version: SpamAssassin 2.61 (1.212.2.1-2003-12-09-exp) on servernd.ccl.net Accelrys Inc. are holding the following training workshops at locations in Europe during January. These events are designed to help you get more value from your Accelrys software, helping you to better accomplish your research goals. Costs are $600 per day for commercial, $520 per day for government and $380 per day for academic. CHEMINFORMATICS Accord Enterprise Clients 24 January in Cambridge, UK DS Accord Enterprise Database Administration 25-26 January in Cambridge, UK Accord Inventory 27 January in Cambridge, UK Accord HTS 28 January in Cambridge, UK For course details and registration see: http://www.accelrys.com/training/cheminf/schedule.html -- Jeffrey L. Nauss, Ph.D. Lead Training Scientist Accelrys 10188 Telesis Court, Suite 100 San Diego, CA 92121 Phone: +1-858-799-5555 Fax: +1-858-799-5100 http://www.accelrys.com/training From chemistry-request@ccl.net Mon Nov 29 10:08:42 2004 Received: from neptune.tranzyme.com (neptune.tranzyme.com [132.210.158.201]) by server.ccl.net (8.12.8/8.12.8) with ESMTP id iATF8evI006253 for ; Mon, 29 Nov 2004 10:08:41 -0500 Received: from mercure.tranzyme.com (dcsher01.tranzyme.com [192.168.1.3]) by neptune.tranzyme.com (8.12.10/8.12.10) with ESMTP id iATFNLIr018467 for ; Mon, 29 Nov 2004 10:23:21 -0500 Content-class: urn:content-classes:message MIME-Version: 1.0 Content-Type: multipart/alternative; boundary="----_=_NextPart_001_01C4D627.711EBD08" X-MimeOLE: Produced By Microsoft Exchange V6.5.7226.0 Subject: CCL: Line minimization failed twice Date: Mon, 29 Nov 2004 10:23:55 -0500 Message-ID: X-MS-Has-Attach: X-MS-TNEF-Correlator: Thread-Topic: CCL: Line minimization failed twice Thread-Index: AcTWJ3Cc8pB9zCnmSzyayAMN7uWVBA== From: "Axel Mathieu" To: "CCL" X-Scanned-By: MIMEDefang 2.48 on 192.168.1.1 X-Spam-Status: No, hits=1.2 required=7.5 tests=HTML_70_80,HTML_MESSAGE, LINES_OF_YELLING,LINES_OF_YELLING_2 autolearn=no version=2.61 X-Spam-Checker-Version: SpamAssassin 2.61 (1.212.2.1-2003-12-09-exp) on servernd.ccl.net This is a multi-part message in MIME format. ------_=_NextPart_001_01C4D627.711EBD08 Content-Type: text/plain; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Greetings, =20 I've been trying out some PM3 and AM1 calculations on some of my = molecules and have obtained the following "error" in some of the log = files: =20 THE LINE MINIMIZATION FAILED TWICE IN A ROW. TAKE CARE! SCF FIELD WAS ACHIEVED =20 =20 I understand that this has already been asked before on CCL (even up to = 1995) and have found solutions to it in the archives (reference: = http://www.ccl.net/cgi-bin/ccl/message.cgi?1995+08+09+008 ). However, it = does not explain the source of this error. I'm relatively new to MOPAC = and would appreciate your help in aiding me to understand the meaning of = this. How does "minimization" fail twice in a row? =20 Many thanks, =20 APM =20 ------_=_NextPart_001_01C4D627.711EBD08 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable

Greetings,

 

I’ve been trying out some PM3 and AM1 = calculations on some of my molecules and have obtained the following “error” = in some of the log files:

 

THE LINE MINIMIZATION FAILED TWICE IN A ROW.=A0=A0 TAKE CARE!

=A0=A0=A0=A0 = SCF FIELD WAS ACHIEVED=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0= =A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0

 

I understand that this has already been asked before = on CCL (even up to 1995) and have found solutions to it in the archives (reference: http:/= /www.ccl.net/cgi-bin/ccl/message.cgi?1995+08+09+008 ). However, it does not explain the source of this error. I’m = relatively new to MOPAC and would appreciate your help in aiding me to understand = the meaning of this. How does “minimization” fail twice in a = row?

 

Many thanks,

 

APM

 

------_=_NextPart_001_01C4D627.711EBD08-- From chemistry-request@ccl.net Mon Nov 29 07:28:30 2004 Received: from mail.biovertis.com (81-223-198-148.arsenal.xdsl-line.inode.at [81.223.198.148]) by server.ccl.net (8.12.8/8.12.8) with ESMTP id iATCSRWu031385 for ; Mon, 29 Nov 2004 07:28:28 -0500 Received: from mail.biovertis.com (localhost [127.0.0.1]) by localhost (Postfix) with ESMTP id 59C3774427 for ; Mon, 29 Nov 2004 13:43:08 +0100 (CET) Received: by mail.biovertis.com (Postfix, from userid 65534) id B49617442A; Mon, 29 Nov 2004 13:43:07 +0100 (CET) Received: from mail.biovertis.com (localhost [127.0.0.1]) by mail.biovertis.com (Postfix) with ESMTP id 631DE74427 for ; Mon, 29 Nov 2004 13:43:06 +0100 (CET) Message-ID: <4241661.1101732186380.SLOX.WebMail.wwwrun|at|mail.biovertis.com> Date: Mon, 29 Nov 2004 13:43:06 +0100 (CET) From: =?UTF-8?Q?Dirk_Cla=C3=9Fen-Houben?= To: CCL Subject: FlexX und SGE In-Reply-To: <20041125001031.74681.qmail|at|web53904.mail.yahoo.com> Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Priority: 3 (normal) X-Mailer: SuSE Linux Openexchange Server 4 - WebMail (Build 2.3826) X-Operating-System: Linux 2.4.21-241-default i386 (JVM 1.3.1_04) Organization: biovertis - information-driven drug design AG References: <20041125001031.74681.qmail|at|web53904.mail.yahoo.com> X-Spam-Checker-Version: SpamAssassin 2.61 (1.212.2.1-2003-12-09-exp) on servernd.ccl.net X-Spam-Level: X-Spam-Status: No, hits=-0.1 required=7.5 tests=MY_DSL,X_OS autolearn=no version=2.61 Dear CCL readers, has anybody some experience running FlexX from BiosolvIT and Tripos on a queuing system with the SGE (Sun Grid Engine)? Every suggestion or example is welkome. Thanks in advance for your help, Regards, Dirk. Dirk Classen-Houben BV Biotechnologies GmbH (Biovertis - information-driven drug design AG) Campus Vienna Biocenter 6 1030 Vienna, Austria Phone +43-1-7989303-110 Fax +43-1-7989303-400 Email dirk.classen-houben|at|biovertis.com From chemistry-request@ccl.net Mon Nov 29 10:27:19 2004 Received: from neptune.tranzyme.com (neptune.tranzyme.com [132.210.158.201]) by server.ccl.net (8.12.8/8.12.8) with ESMTP id iATFRHvI006871 for ; Mon, 29 Nov 2004 10:27:17 -0500 Received: from mercure.tranzyme.com (dcsher01.tranzyme.com [192.168.1.3]) by neptune.tranzyme.com (8.12.10/8.12.10) with ESMTP id iATFfwIr019006 for ; Mon, 29 Nov 2004 10:41:58 -0500 Content-class: urn:content-classes:message MIME-Version: 1.0 Content-Type: multipart/alternative; boundary="----_=_NextPart_001_01C4D62A.0AD456B8" X-MimeOLE: Produced By Microsoft Exchange V6.5.7226.0 Subject: CCL: Summary for "Forcefields for Macrocycles" Date: Mon, 29 Nov 2004 10:42:32 -0500 Message-ID: X-MS-Has-Attach: X-MS-TNEF-Correlator: Thread-Topic: CCL: Summary for "Forcefields for Macrocycles" Thread-Index: AcTWKgpSgys7Iby0SKOBCAec/wUSfw== From: "Axel Mathieu" To: X-Scanned-By: MIMEDefang 2.48 on 192.168.1.1 X-Spam-Status: No, hits=2.0 required=7.5 tests=HTML_60_70, HTML_FONTCOLOR_UNKNOWN,HTML_MESSAGE autolearn=no version=2.61 X-Spam-Checker-Version: SpamAssassin 2.61 (1.212.2.1-2003-12-09-exp) on servernd.ccl.net This is a multi-part message in MIME format. ------_=_NextPart_001_01C4D62A.0AD456B8 Content-Type: text/plain; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Here is the summary of responses I've obtained for my post last week = (following my recent search in the CCL archives, I noticed that the = summary posts are important for the transfer of information so here = goes): =20 -------------------------------------------------------------------------= ---------- Original Post: -------------------------------------------------------------------------= ---------- Greetings to all, =20 I've been having a discussion with some of my colleagues about = forcefields and the question came about the use of a proper forcefields = for macrocyclic molecules, given our recent NMR developments here. I've = been modeling these types of molecules for about 2 years now and have = been using a modified MMFFF94s forcefield for all conformational = searches for various reasons but mostly as this in my opinion, is the = best forcefield at hand for me right now. =20 Are any of you aware of special forcefields or have developed a specific = forcefield for macrocycles? Or then again, what forcefields are you = using for macrocyles? Your opinion/experience on this is most valuable = to me. =20 Again, many thanks to the CCL community for your never ending help, =20 APM =20 -------------------------------------------------------------------------= ---------- Responses: -------------------------------------------------------------------------= ---------- 1) I have used the MMFF94 to determine the structure of 3 derivatives of = erythromycin. Erythromycin is a 14-membered macrocyclic ring to which = is appended two sugar residues. I am confident in the results. I use = the force field through SYBYL and employ a number of approaches in an = attempt to search conformational space thoroughly. Wayne E. Steinmetz =20 2) Hi Axel, A few years ago I was working on QM/MM methods for MD simulations of = macrocycles (18-crown-6, etc.). I combined AM1 with some torsion terms = modified from the Amber forcefield. You can get the references from = this webpage: http://www.arguslab.com/markthompson.htm=20 Cheers, Mark Thompson =20 3) Dear Alex,=20 One attempt to develop a specific force field for macrocyclic = polyketides is described in "Kahn, K.; Bruice, T. C. Parametrization of = OPLS-AA force field for the conformational analysis of macrocyclic = polyketides. J. Comput. Chem. 2002, 23, 977-996" =20 However, there is little macrocycle-specific in this parameterization; = it was more focused on parameterizing individual functional groups that = are found in the polyketide FK506.=20 Best wishes,=20 Kalju ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Dr. Kalju Kahn =20 =20 -------------------------------------------------------------------------= ---------- Many thanks to all who have replied, APM -------------------------------------------------------------------------= ---------- =20 ------_=_NextPart_001_01C4D62A.0AD456B8 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable

Here is the summary of responses I’ve obtained = for my post last week (following my recent search in the = CCL archives, I noticed that the summary posts are important for the transfer of = information so here goes):

 

------------------------------------------------------= -----------------------------

Original Post:

------------------------------------------------------= -----------------------------

Greetings to all,

 

I’ve been having a discussion with some of my colleagues about forcefields and the = question came about the use of a proper forcefields for = macrocyclic molecules, given our recent NMR = developments here. I’ve been modeling these types of molecules for about 2 = years now and have been using a modified MMFFF94s forcefield for all conformational searches for various reasons but mostly as this = in my opinion, is the best forcefield at hand for = me right now.

 

Are any of you aware of special forcefields or have developed a specific forcefield for = macrocycles? Or then again, what forcefields are you using for macrocyles? Your = opinion/experience on this is most valuable to me.

 

Again, many thanks to the = CCL community for your never ending = help,

 

APM

 

------------------------------------------------------= -----------------------------

Responses:

------------------------------------------------------= -----------------------------

1)

I have used the MMFF94 to determine = the structure of 3 derivatives of erythromycin.  Erythromycin is a = 14-membered macrocyclic ring to which is appended two sugar residues.  I am confident in the = results.  I use the force field through SYBYL and employ a number of approaches in = an attempt to search conformational space = thoroughly.

Wayne E. = Steinmetz

 

2)

Hi = Axel,

A few years ago I was working on = QM/MM methods for MD simulations of macrocycles = (18-crown-6, etc.).  I combined AM1 with some torsion terms modified from the = Amber forcefield.  You can get the references from = this webpage:  http://www.arguslab.com= /markthompson.htm 

Cheers,
Mark Thompson

 

3)

Dear Alex,

One attempt to develop a specific force field for macrocyclic polyketides is described in "Kahn, K.; = Bruice, T. C. Parametrization of OPLS-AA force field for the conformational analysis of macrocyclic polyketides. J. Comput. Chem. 2002, 23, 977-996"=A0 =

However, there is little macrocycle-specific in this parameterization; it was more focused on parameterizing individual functional groups that are found in the polyketide FK506.

Best wishes,

Kalju

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

Dr. Kalju Kahn

 

 

------------------------------------------------------= -----------------------------

Many thanks to all who have = replied,

APM

------------------------------------------------------= -----------------------------

 

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