From owner-chemistry@ccl.net Wed Feb  7 03:40:00 2007
From: "Carsten Detering detering__biosolveit.de" <owner-chemistry,,server.ccl.net>
To: CCL
Subject: CCL: Visualization Freeware
Message-Id: <-33551-070207033702-12782-eXfyFkFbrDCD+FW6uDLh3g,,server.ccl.net>
X-Original-From: "Carsten  Detering" <detering#%#biosolveit.de>
Date: Wed, 7 Feb 2007 03:36:59 -0500


Sent to CCL by: "Carsten  Detering" [detering,+,biosolveit.de]
Dear Young,

you can use FlexV, which you can download for free from the BioSolveIT web site:
http://www.biosolveit.de/download
It has a PovRay ray tracer incorporated.
One picture made with FlexV is this on the FlexX page for example:
http://www.biosolveit.de/flexx

Hope this helps,

Carsten


------------------------------------------------------------------
BioSolveIT GmbH - An der Ziegelei 75 - 53757 St.Augustin - Germany
Dr. Carsten Detering, Appl. Scientist       detering]^[biosolveit.de
Phone: +49-2241-2525-0 / Fax: -525               www.biosolveit.de


> Sent to CCL by: "Young  Leh" [youngleh{=}gmail.com]
> > Dear CCLer,
> > 
> > I am now looking for a visualization freeware that can be used to
produce 3D molecular pictures with publishable quality.  Could
somebody please give me some hints?
> > 
> > Thanks and have a great day.
> > 
> > Young Leh>


From owner-chemistry@ccl.net Wed Feb  7 06:42:00 2007
From: "Rene Thomsen rt*|*molegro.com" <owner-chemistry _ server.ccl.net>
To: CCL
Subject: CCL: Molegro
Message-Id: <-33552-070207061008-15680-SaYOmtiFoITEvETWnau7Gg _ server.ccl.net>
X-Original-From: "Rene Thomsen" <rt-.-molegro.com>
Content-Disposition: inline
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Date: Wed, 7 Feb 2007 11:12:55 +0100
MIME-Version: 1.0


Sent to CCL by: "Rene Thomsen" [rt- -molegro.com]
Hi,

An easier way to convert proteins to ligands is to use the context
menu on the specific molecule in the 'Workspace Explorer' window and
select the 'Convert Protein to Ligand' option.

Notice that Molegro Virtual Docker is not designed for protein-protein
docking - it is mainly targeted for docking small 'drug-like'
molecules.

Kind regards,
Rene
---
Rene Thomsen
Molegro
Hoegh-Guldbergs Gade 10, Bldg. 1090
DK-8000 Aarhus C
Denmark
http://www.molegro.com

On 2/7/07, Richard Leo Wood rwoodphd*|*msn.com <owner-chemistry[-]ccl.net> wrote:
>
> Sent to CCL by: "Richard Leo Wood" [rwoodphd###msn.com]
> Hi all,
>
> Actually, I found my own workaround, as I usually do.
>
> Take the peptide (as a pdb file), convert it to an xyz file.  Change the unknown atoms to teh correct ones, then convert this to a mol format file.  Then import the mol file into Molegro and do the docking calculations.
>
> Richard
>
>
>
>
>                 From: "Richard L Wood rwoodphd{:}msn.com" <owner-chemistry[a]ccl.net>
> Reply-To: "CCL Subscribers" <chemistry[a]ccl.net>
> To: "Wood, Richard L. -id3m4-" <rwoodphd[a]msn.com>
> Subject: CCL: Molegro
> Date: Tue, 6 Feb 2007 18:58:02 -0500
>
> Sent to CCL by: "Richard L Wood" [rwoodphd ~ msn.com]
> Hi all,
>
> I've just started using Molegro to dock ligands to proteins and I am having some difficulty.
>
> I can import a protein alright, but when I import a ligand (which is a small peptide in this case), it calls it a protein.  So, I have two proteins and no ligands.
>
> Is there a way in Molegro that I can trick it into seeing my peptide as a ligand so that I can dock it?
>
> TIA,
> Richard

From owner-chemistry@ccl.net Wed Feb  7 12:10:00 2007
From: "Richard Leo Wood rwoodphd(a)msn.com" <owner-chemistry . server.ccl.net>
To: CCL
Subject: CCL: Molegro
Message-Id: <-33553-070207120857-2747-mK/nlsIcw0zsd3wF3EGYFA . server.ccl.net>
X-Original-From: "Richard Leo Wood" <rwoodphd|,|msn.com>
Date: Wed, 7 Feb 2007 12:08:53 -0500


Sent to CCL by: "Richard Leo Wood" [rwoodphd!A!msn.com]
Hi all,

My ligands are hexapeptides, so they are not really proteins, but I suppose could be classified as "small molecules".  They are known to inhibit the receptor I am trying to "dock" them to (actually I'm trying to estimate the binding energies to the receptor).

I have a concern about the results that I am getting.  They don't seem to be reproducible.  That is, if I run the same docking calculation over and over again, I get different results.  I wonder why that is. I've noticed that the cavity sizes (for the largest cavity) vary from run to run, as well.

I would think that if I used the same settings each time, I should get the same binding affinities, but I'm not.

TIA,
Richard



Sent to CCL by: "Rene Thomsen" [rt- -molegro.com]
Hi,

An easier way to convert proteins to ligands is to use the context
menu on the specific molecule in the 'Workspace Explorer' window and
select the 'Convert Protein to Ligand' option.

Notice that Molegro Virtual Docker is not designed for protein-protein
docking - it is mainly targeted for docking small 'drug-like'
molecules.

Kind regards,
Rene
---
Rene Thomsen
Molegro
Hoegh-Guldbergs Gade 10, Bldg. 1090
DK-8000 Aarhus C
Denmark
http://www.molegro.com

On 2/7/07, Richard Leo Wood rwoodphd*|*msn.com <owner-chemistry===ccl.net> wrote:
 	 	
Sent to CCL by: "Richard Leo Wood" [rwoodphdmsn.com]
Hi all,

Actually, I found my own workaround, as I usually do.

Take the peptide (as a pdb file), convert it to an xyz file.  Change the unknown atoms to teh correct ones, then convert this to a mol format file.  Then import the mol file into Molegro and do the docking calculations.

Richard


From owner-chemistry@ccl.net Wed Feb  7 13:43:00 2007
From: "Steve Williams willsd : appstate.edu" <owner-chemistry=server.ccl.net>
To: CCL
Subject: CCL:G: IRC in general and in Gaussian
Message-Id: <-33554-070207133452-29107-J2eiYHLNN7cRNuWjraQcSA=server.ccl.net>
X-Original-From: Steve Williams <willsd^^^appstate.edu>
Content-Transfer-Encoding: 7bit
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Date: Wed, 07 Feb 2007 13:21:37 -0500
MIME-Version: 1.0


Sent to CCL by: Steve Williams [willsd:-:appstate.edu]
I am studying a series of gas phase, rather small molecule reactions.  
My initial investigations have shown that geometries and thermal 
corrections from MP2 6-31++G(d) optimizations and frequency 
calculations, followed by higher accuracy single point calculations 
gives quite nice agreement with a good deal of experimental data. 
Vizualization of the single imaginary frequency mode for transition 
state optimizations always shows a mode the appears to be the desired 
reaction coordinate.  I have been using IRC calculations with the above 
MP2 method to confirm that reaction transition states connect desired 
reactants and products, which they seem to do.  I am doing these in mass 
weighted coordinates in Gaussian 03, but I do not think my question is 
at all specific to Gaussian.  My question is:

How far along a reaction coordinate should an IRC be followed to confirm 
the connection to products and reactants?  For my studies the reactant 
side and product side final structures (seen in a viz. program) look 
like they would eventually converge to the reactant or product 
structure. However, in most cases if I continue the IRC with too many 
points (or too far along the reaction coordinate) the calculation fails 
with an scf convergence error method.  Scf=(qc,vtl) allows the IRC to go 
a bit farther than the default DIIS converger, but it eventually fails 
as well.  My reactions are bimolecular with bimolecular products and the 
reaction coordinates are mostly H atom transfers.  So, is there any 
general opinion out there on "how far" is "far enough" to claim that an 
IRC calculation demonstrates the connection from reactants to products 
via a transition state. 

Thanks for any advice.

Steve Williams


From owner-chemistry@ccl.net Wed Feb  7 15:21:00 2007
From: "Guilherme Menegon Arantes garantes::iq.usp.br" <owner-chemistry]![server.ccl.net>
To: CCL
Subject: CCL: soft/hardware requirements for large multiconfig. calculations
Message-Id: <-33555-070207150714-22206-6dnlDDGNaP9xBOCQlmcxng]![server.ccl.net>
X-Original-From: Guilherme Menegon Arantes <garantes{:}iq.usp.br>
Content-Disposition: inline
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Date: Wed, 7 Feb 2007 18:06:18 -0200
MIME-Version: 1.0


Sent to CCL by: Guilherme Menegon Arantes [garantes{}iq.usp.br]

Dear members,

It would be interesting to know which hardware and software
configurations you are using to run large active space and large basis
set multiconfigurational (mainly CASSCF/CASPT2) quantum chemical
computations.

64bit workstations should be a good choice nowadays, but:
- how much RAM?
- how much disk? What kind of disk?
- any dual core issues?
- any special hardware?

What about software:
- using MOLCAS? MOLPRO? DALTON? Other?
- any code modifications?
- which compiler? Any special flags?

Real examples or figures (e.g., which active space run with which amount
of RAM/disk) would be very helpful, too.

I will sumarize the replies. Kind Regards,

G

--

Guilherme Menegon Arantes, PhD       Sao Paulo, Brasil
______________________________________________________


From owner-chemistry@ccl.net Wed Feb  7 17:24:00 2007
From: "Block, John john.block/./oregonstate.edu" <owner-chemistry=-=server.ccl.net>
To: CCL
Subject: CCL: ACS Symposium Boston August 2007 "QSAR Reborn"
Message-Id: <-33556-070207144337-20933-HQIjm3o2MBQCySLsBh1tdA=-=server.ccl.net>
X-Original-From: "Block, John" <john.block|,|oregonstate.edu>
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Date: Wed, 7 Feb 2007 10:44:22 -0800
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Sent to CCL by: "Block, John" [john.block_._oregonstate.edu]
This is a multi-part message in MIME format.

------_=_NextPart_001_01C74AE7.FBBF8B77
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You are encouraged to submit a paper for the symposium "QSAR Reborn:
Modern QSAR Techniques and Applications - A Symposium in Memory of  Dr.
Phillip Magee" that will be held the during Boston American Chemical
Society Meeting August 19-23, 2007.  The Division of Computers in
Chemistry (COMP) is the primary sponsor.

=20

Organizers:

        Dr. Robert Clark (Tripos)  bclark^-^tripos.com=20

        Dr. John H. Block (Oregon State University)
John.Block^-^oregonstate.edu=20

        Dr. Lowell Hall (Hall Associates)  halllh^-^comcast.net=20

=20

Division Co-Sponsorship:

        COMP (Lead sponsor) and AGRO=20

=20

Purpose:

        Dr. Phillip Magee was one of the pioneers in utilizing QSAR.
Whereas it is common to apply this technique to bioactivities in humans,
he showed its application to agrochemicals.  After retiring from the
Ortho Chemical Division of Standard Oil, Phil used QSAR to study
transdermal properties of molecules.  Until his stroke, Phil was
utilizing both his knowledge of physical organic chemistry and qsar
descriptors to model bioactivities.  Thus, it is appropriate that a
symposium in his honor include speakers who develop qsar methodologies
and who apply qsar methodologies to solve problems.  Phil was also the
first President of the International QSAR Group and served for a number
of years. An introductory speaker should give a short biography of Phil
and describe his work.

=20

Papers must be submitted through the ACS OASYS system at:
http://oasys.acs.org/acs/234nm/comp/papers/index.cgi  The deadline is
April 2, 2007.

=20

Topics:

        QSAR Descriptors

                Physico-chemical

                Topological

                Quantum Mechanics

                Geometrical/Stereochemical

=20

        QSAR Techniques

                2D-QSAR

                3D-QSAR

                Topological QSAR

                Neural networks

                Classification Methods

               =20

        QSAR Applications

                Drug design

                Agrochemical design

                Toxicities

                Environmental properties

=20

=20

John H. Block                    Phone:  541-737-5779

College of Pharmacy         Fax:      541-737-3999

Oregon State University

Corvallis, OR 97331

John.Block^-^oregonstate.edu

blockj^-^onid.orst.edu

=20

=20


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<p class=3DMsoNormal><font size=3D3 face=3D"Times New Roman"><span =
style=3D'font-size:
12.0pt'>You are encouraged to submit a paper for the symposium =
&#8220;QSAR
Reborn:&nbsp; Modern QSAR Techniques and Applications - A Symposium in =
Memory
of &nbsp;Dr. Phillip Magee&#8221; that will be held the during Boston =
American
Chemical Society Meeting August 19-23, 2007.&nbsp; The Division of =
Computers in
Chemistry (COMP) is the primary sponsor.<o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 face=3D"Times New Roman"><span =
style=3D'font-size:
12.0pt'><o:p>&nbsp;</o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 face=3D"Times New Roman"><span =
style=3D'font-size:
12.0pt'>Organizers:<o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 face=3D"Times New Roman"><span =
style=3D'font-size:
12.0pt'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Dr. Robert Clark =
(Tripos) &nbsp;<a
href=3D"mailto:bclark^-^tripos.com">bclark^-^tripos.com</a> =
<o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 face=3D"Times New Roman"><span =
style=3D'font-size:
12.0pt'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Dr. John H. Block =
(<st1:place
w:st=3D"on"><st1:PlaceName w:st=3D"on">Oregon</st1:PlaceName> =
<st1:PlaceType w:st=3D"on">State</st1:PlaceType>
 <st1:PlaceType =
w:st=3D"on">University</st1:PlaceType></st1:place>)&nbsp; <a
href=3D"mailto:John.Block^-^oregonstate.edu">John.Block^-^oregonstate.edu</a>=
 <o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 face=3D"Times New Roman"><span =
style=3D'font-size:
12.0pt'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Dr. Lowell Hall (Hall
Associates) &nbsp;<a =
href=3D"mailto:halllh^-^comcast.net">halllh^-^comcast.net</a> =
<o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 face=3D"Times New Roman"><span =
style=3D'font-size:
12.0pt'><o:p>&nbsp;</o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 face=3D"Times New Roman"><span =
style=3D'font-size:
12.0pt'>Division Co-Sponsorship:<o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 face=3D"Times New Roman"><span =
style=3D'font-size:
12.0pt'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; COMP (Lead sponsor) =
and AGRO
<font color=3Dblack><span =
style=3D'color:black'><o:p></o:p></span></font></span></font></p>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
style=3D'font-size:12.0pt;color:black'><o:p>&nbsp;</o:p></span></font></p=
>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
style=3D'font-size:12.0pt;color:black'>Purpose:<o:p></o:p></span></font><=
/p>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
style=3D'font-size:12.0pt;color:black'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbs=
p;&nbsp; Dr.
Phillip Magee was one of the pioneers in utilizing QSAR.&nbsp; Whereas =
it is
common to apply this technique to bioactivities in humans, he showed its
application to agrochemicals.&nbsp; After retiring from the Ortho =
Chemical
Division of Standard Oil, Phil used QSAR to study transdermal properties =
of
molecules.&nbsp; Until his stroke, Phil was utilizing both his knowledge =
of
physical organic chemistry and qsar descriptors to model =
bioactivities.&nbsp;
Thus, it is appropriate that a symposium in his honor include speakers =
who
develop qsar methodologies and who apply qsar methodologies to solve =
problems.&nbsp;
Phil was also the first President of the International QSAR Group and =
served
for a number of years. An introductory speaker should give a short =
biography of
Phil and describe his work.<o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
style=3D'font-size:12.0pt;color:black'><o:p>&nbsp;</o:p></span></font></p=
>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
style=3D'font-size:12.0pt;color:black'>Papers must be submitted through =
the ACS
OASYS system at: &nbsp;&nbsp;<a
href=3D"http://oasys.acs.org/acs/234nm/comp/papers/index.cgi">http://oasy=
s.acs.org/acs/234nm/comp/papers/index.cgi</a>
&nbsp;The deadline is April 2, 2007.<o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
style=3D'font-size:12.0pt;color:black'><o:p>&nbsp;</o:p></span></font></p=
>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
style=3D'font-size:12.0pt;color:black'>Topics:<o:p></o:p></span></font></=
p>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
style=3D'font-size:12.0pt;color:black'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbs=
p;&nbsp; QSAR
Descriptors<o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
style=3D'font-size:12.0pt;color:black'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbs=
p;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; =
Physico-chemical<o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
style=3D'font-size:12.0pt;color:black'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbs=
p;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; =
Topological<o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
style=3D'font-size:12.0pt;color:black'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbs=
p;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Quantum
Mechanics<o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
style=3D'font-size:12.0pt;color:black'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbs=
p;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; =
Geometrical/Stereochemical<o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
style=3D'font-size:12.0pt;color:black'><o:p>&nbsp;</o:p></span></font></p=
>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
style=3D'font-size:12.0pt;color:black'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbs=
p;&nbsp; </span></font><font
color=3Dblack><span lang=3DFR style=3D'color:black'>QSAR =
Techniques<o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
lang=3DFR =
style=3D'font-size:12.0pt;color:black'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbs=
p;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; =
2D-QSAR<o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
lang=3DFR =
style=3D'font-size:12.0pt;color:black'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbs=
p;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; =
3D-QSAR<o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
lang=3DFR =
style=3D'font-size:12.0pt;color:black'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbs=
p;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; =
</span>Topological
QSAR<o:p></o:p></font></p>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
style=3D'font-size:12.0pt;color:black'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbs=
p;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Neural
networks<o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
style=3D'font-size:12.0pt;color:black'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbs=
p;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Classification
Methods<o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
style=3D'font-size:12.0pt;color:black'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbs=
p;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; =
<o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
style=3D'font-size:12.0pt;color:black'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbs=
p;&nbsp; QSAR
Applications<o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
style=3D'font-size:12.0pt;color:black'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbs=
p;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Drug
design<o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
style=3D'font-size:12.0pt;color:black'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbs=
p;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Agrochemical
design<o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
style=3D'font-size:12.0pt;color:black'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbs=
p;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; =
Toxicities<o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
style=3D'font-size:12.0pt;color:black'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbs=
p;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Environmental
properties<o:p></o:p></span></font></p>

<p class=3DMsoNormal><font size=3D3 color=3Dblack face=3D"Times New =
Roman"><span
style=3D'font-size:12.0pt;color:black'><o:p>&nbsp;</o:p></span></font></p=
>

<p class=3DMsoNormal><font size=3D2 face=3DArial><span =
style=3D'font-size:10.0pt;
font-family:Arial'><o:p>&nbsp;</o:p></span></font></p>

<p class=3DMsoNormal><strong><b><font size=3D2 face=3DArial><span =
style=3D'font-size:
10.0pt;font-family:Arial'>John H. =
Block&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&n=
bsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
Phone:&nbsp; 541-737-5779</span></font></b></strong><o:p></o:p></p>

<p class=3DMsoNormal><st1:place w:st=3D"on"><st1:PlaceType =
w:st=3D"on"><strong><b><font
  size=3D2 face=3DArial><span =
style=3D'font-size:10.0pt;font-family:Arial'>College</span></font></b></s=
trong></st1:PlaceType><strong><b><font
 size=3D2 face=3DArial><span =
style=3D'font-size:10.0pt;font-family:Arial'> of <st1:PlaceName
 =
w:st=3D"on">Pharmacy</st1:PlaceName></span></font></b></strong></st1:plac=
e><strong><b><font
size=3D2 face=3DArial><span =
style=3D'font-size:10.0pt;font-family:Arial'>&nbsp;&nbsp;&nbsp;&nbsp;&nbs=
p;&nbsp;&nbsp;&nbsp;
Fax:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; =
541-737-3999</span></font></b></strong><o:p></o:p></p>

<p class=3DMsoNormal><st1:place w:st=3D"on"><st1:PlaceName =
w:st=3D"on"><strong><b><font
  size=3D2 face=3DArial><span =
style=3D'font-size:10.0pt;font-family:Arial'>Oregon</span></font></b></st=
rong></st1:PlaceName><strong><b><font
 size=3D2 face=3DArial><span =
style=3D'font-size:10.0pt;font-family:Arial'> <st1:PlaceType
 w:st=3D"on">State</st1:PlaceType> <st1:PlaceType =
w:st=3D"on">University</st1:PlaceType></span></font></b></strong></st1:pl=
ace><o:p></o:p></p>

<p class=3DMsoNormal><st1:place w:st=3D"on"><st1:City =
w:st=3D"on"><strong><b><font
  size=3D2 face=3DArial><span =
style=3D'font-size:10.0pt;font-family:Arial'>Corvallis</span></font></b><=
/strong></st1:City><strong><b><font
 size=3D2 face=3DArial><span =
style=3D'font-size:10.0pt;font-family:Arial'>, <st1:State
 w:st=3D"on">OR</st1:State> <st1:PostalCode =
w:st=3D"on">97331</st1:PostalCode></span></font></b></strong></st1:place>=
<o:p></o:p></p>

<p class=3DMsoNormal><strong><b><font size=3D2 face=3DArial><span =
style=3D'font-size:
10.0pt;font-family:Arial'><a =
href=3D"mailto:John.Block^-^oregonstate.edu">John.Block^-^oregonstate.edu</a>=
</span></font></b></strong><o:p></o:p></p>

<p class=3DMsoNormal><strong><b><font size=3D2 face=3DArial><span =
style=3D'font-size:
10.0pt;font-family:Arial'><a =
href=3D"mailto:blockj^-^onid.orst.edu">blockj^-^onid.orst.edu</a></span></fon=
t></b></strong><o:p></o:p></p>

<p class=3DMsoNormal><font size=3D3 face=3D"Times New Roman"><span =
style=3D'font-size:
12.0pt'>&nbsp;</span><o:p></o:p></font></p>

<p class=3DMsoNormal><font size=3D3 face=3D"Times New Roman"><span =
style=3D'font-size:
12.0pt'><o:p>&nbsp;</o:p></span></font></p>

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