From ipcakc@vigyan.ernet.in Wed Aug 28 13:09:16 1993 Received: from relay1.UU.NET for ipcakc@vigyan.ernet.in by oscsunb.ccl.net (5.65c+KVa/930601.1506) id AA27360; Sat, 28 Aug 1993 10:40:08 -0400 Received: from spool.uu.net (via LOCALHOST) by relay1.UU.NET with SMTP (5.61/UUNET-internet-primary) id AB29996; Sat, 28 Aug 93 10:40:07 -0400 Received: from sangam.UUCP by uucp5.uu.net with UUCP/RMAIL (queueing-rmail) id 103855.10282; Sat, 28 Aug 1993 10:38:55 EDT Received: from vigyan.UUCP by sangam.ncst.ernet.in (4.1/SMI-4.2-ERNET-relay) with UUCP id AA26632; Sat, 28 Aug 93 20:00:44+0530 Received: by iisc.ernet.in (ERNET-IISc/AT&T UNIX SYS V.3.2) id AA22525; Sat, 28 Aug 93 19:13:08 EDT Received: by vigyan.iisc.ernet.in (smail2.3) id AA11116; 28 Aug 93 18:09:16 EST (Sat) To: CHEMISTRY@ccl.net Subject: CNDO/S-C.I. Date: 28 Aug 93 18:09:16 EST (Sat) From: ipcakc@vigyan.iisc.ernet.in Message-Id: <9308281809.AA11116@vigyan.iisc.ernet.in> Hi netters, Is anybody willing to send me CNDO/S-C.I. program? If possible please send me through e-mail with detailed inputs. bye. D.Sengupta. IISc Bangalore India ipcakc@ipc.iisc.ernet.in From tudor@wucmd.wustl.edu Sat Aug 28 06:27:32 1993 Received: from wuecl (wuecl.wustl.edu) for tudor@wucmd.wustl.edu by oscsunb.ccl.net (5.65c+KVa/930601.1506) id AA29871; Sat, 28 Aug 1993 14:21:30 -0400 Return-Path: Received: from wucmd.wustl.edu by wuecl with SMTP (5.65a/1.35); id AA29587; Sat, 28 Aug 93 13:21:19 -0500 Received: by wucmd (911016.SGI/911001.SGI) for @wuecl.wustl.edu:chemistry@ccl.net id AA22268; Sat, 28 Aug 93 11:48:24 -0500 Date: Sat, 28 Aug 1993 11:27:32 -0500 (CDT) From: Tudor Oprea Subject: Re: comments on drug modeling software To: morgan conn Cc: chemistry@ccl.net In-Reply-To: <9308262037.AA12838@esau.mit.edu> Message-Id: Mime-Version: 1.0 Content-Type: TEXT/PLAIN; charset=US-ASCII On Thu, 26 Aug 1993, morgan conn wrote: > > Hello netters, > > I am interested in computational packages for drug design (ones that include > minimization, database management, and pharmacophore prediction). I've seen > vague mentions of a number of these at ACS meetings and such (too bad I've > missed the latest), but want to find out from 'those in the know' what is good/ > bad/ugly. > > Can anyone tell me something about programs of this nature? I would especially be > interested in hearing from those on the list in the pharmaceutical industry. > >> are those in academia biased ? ;-) >> (T.O.) > -mmc > > > ********************************************************* > Morgan Conn > MIT Chemistry, 18-148, Cambridge, MA 02139; > mmconn@esau.mit.edu, 617.253.6438, 617.253.7929 (fax) > ********************************************************* > > Morgan, I guess it depends on the available data that you wish to tackle with. 1. If you have a series of cpds that have reliable functional and binding data, you may wish to use QSAR methodology (that is, Quant. Struct-Act. Relat), and i suggest CoMFA (Comparative Molecular Field Analysis) by Cramer et al, available from Tripos Associates. Their package is called Sybyl, and in the 3D-QSAR field is one of the best available, as it comes with a good chemometric package (CoMFA uses Partial Least Squares method developed by Wold et al; enhancements are probably available soon - PLS optimization methods from Clementi et al). When you use CoMFA you need an alignment (that is, conformational analysis and superposition rules). You can use the Tripos force-field, but also MM2 (if you buy it), and several minimizers are available (including Simplex, BFGS, conjugate gradient). If you have peptides, you could use Amber. 2. If you have just a lead compound and a rather scarce set of data, you can either a. scan the literature and gather some more or b. ask your colleagues if previous attempts were made in the same directin or c. get Biosym & Apex 3D (from Golender et al), that would help you with pharmacophore ID and assist you in your (Q)SAR efforts. Biosym has also a very good package for ligand design - Ludi (from Hans Boehm), which may assist you if you have a known binding site. Force fields: CVFF, Amber plus some other options. 3. For database management, you may wish to use software available from Daylight, which is specifically designed for this (& other) purpose(s). PS: I did not include phone numbers or email, since i do not wish this to sound like an advertisement. There's other software out there that does similar things, but i tried to get you first (hands on) experience - so the rest is not ignored, it simply means i did not use it. Tudor Oprea (tudor@wucmd.wustl.edu) Research Associate Center for Molecular Design, Washington University, St. Louis PPS: you could have seen Tripos, Bisoym and Daylight expose their software at the ACS meeting exposition, in Chicago, this week! For those who are looking for decisions, i suggest you take your time and see the next expo, at the next ACS meeting, spring 94. From PCJ@PSUVM.PSU.EDU Sat Aug 28 11:53:00 1993 Received: from phem3 (phem3.acs.ohio-state.edu) for PCJ@PSUVM.PSU.EDU by oscsunb.ccl.net (5.65c+KVa/930601.1506) id AA00942; Sat, 28 Aug 1993 15:52:41 -0400 Received: from PSUVM.PSU.EDU (MAILER@PSUVM) by phem3.acs.ohio-state.edu (PMDF V4.2-13 #3557) id <01H2A8XQZ3TS8X2UE6@phem3.acs.ohio-state.edu>; Sat, 28 Aug 1993 15:52:30 EDT Received: from PSUVM.PSU.EDU (NJE origin PCJ@PSUVM) by PSUVM.PSU.EDU (LMail V1.1d/1.7f) with RFC822 id 4606; Sat, 28 Aug 1993 15:53:50 -0400 Date: Sat, 28 Aug 1993 15:53 -0400 (EDT) From: PCJ@PSUVM.PSU.EDU Subject: Seeking Information about Genetic Algorithms To: chemistry@ccl.net Message-Id: <01H2A8XQZ3TU8X2UE6@phem3.acs.ohio-state.edu> Content-Transfer-Encoding: 7BIT Dear Netters: Not very much has been published on GA applications in physical sciences or chemistry or related disciplines. I am looking for recent papers or work in progress using GA in chemistry. Do you know of such work? Could you please pass along any information you have? Thanks for the help. Peter Jurs, Penn State University Chemistry Department pcj@psuvm.psu.edu From Y0XIAO01@ULKYVX.LOUISVILLE.EDU Sat Aug 28 17:19:19 1993 Received: from ulkyvx.louisville.edu for Y0XIAO01@ULKYVX.LOUISVILLE.EDU by oscsunb.ccl.net (5.65c+KVa/930601.1506) id AA05484; Sat, 28 Aug 1993 22:20:13 -0400 Received: from ULKYVX.LOUISVILLE.EDU by ULKYVX.LOUISVILLE.EDU (PMDF V4.2-11 #3949) id <01H2AM1JA9TW95O8JP@ULKYVX.LOUISVILLE.EDU>; Sat, 28 Aug 1993 22:19:19 EST Date: Sat, 28 Aug 1993 22:19:19 -0500 (EST) From: "Leon Y. Xiao, (502)635-6931" Subject: Re: Seeking Information about Genetic Algorithms To: PCJ@PSUVM.PSU.EDU Cc: chemistry@ccl.net Message-Id: <01H2AM1JA9TY95O8JP@ULKYVX.LOUISVILLE.EDU> X-Vms-To: IN%"PCJ@PSUVM.PSU.EDU" X-Vms-Cc: IN%"chemistry@ccl.net",Y0XIAO01 Mime-Version: 1.0 Content-Type: TEXT/PLAIN; CHARSET=US-ASCII Content-Transfer-Encoding: 7BIT Hi, Peter: In your mail, >Dear Netters: >Not very much has been published on GA applications in >physical sciences or chemistry or related disciplines. >I am looking for recent papers or work in progress using >GA in chemistry. Do you know of such work? Could you please >pass along any information you have? Thanks for the help. >Peter Jurs, Penn State University Chemistry Department >pcj@psuvm.psu.edu Following is a list of publications (most, but not limited) you may be interested in. Leon Xiao University of Louisville Chemistry Department ============================================================== [BOOKS] Holland, J. H. Adaptation in natural and artificial systems: an introductory analysis with applications to biology, control, and artificial intelligence. University of Michigan Press, Ann Arbor, MI. (1975). Davis, L. Genetic Algorithms and simulated annealing. Morgan Kaufmann Publishers, Los Altos, CA.(1987). Goldberg, D. E. Genetic algorithms in search, optimization, and machine learning, Addision-Wesley, New York. (1989). Davis, L. Handbook of genetic algorithms. Van Nostrand Reinhold, NY. (1991). Z. Michalewicz, Springer Verlag Genetic algorthms + Data Structures = evolution programs; (1992). [CONFERENCE PROCEEDINGS] Grefenstette, J. J. Genetic algorithms and their applications: proceeding of the second International Conference on Genetic Algorithms. L. Erlbaum Associates, Hillsdale, NJ. (1987). Schaffer, J. D. Proceedings of the Third International Conference on Genetic Algorithms. Morgan Kaufmann Publishers, San Mateo, CA.(1989). Belew, R. K. and Booker, L. B. Proceedings of the Fourth International Conference on Genetic Algorithms. Morgan Kaufmann Publishers, San Mateo, CA. (1991). Forest, S. ed., Proceedings of the Fifth International Conference on Genetic Algorithms, Morgan Kaufmann Publishers, San Mateo, CA (1993). [ARTICLES RELATED TO CHEMISTRY] P. Tuffery and C. Etchebest and S. Hazout and R. Lavery, A New Approach to the Rapid Determination of Protein Side Chain Conformations, Journal of Biomolecular Structure & Dynamics, 8(6), 1267, (1991) Thomas Dandekar and Patrick Argos, Potential of genetic algorithms in protein folding and protein engineering simulations, Protein Engineering 5(7), 637-645, (1992) Denning, Peter J. Genetic algorithms, American Scientist, 80, 12-14, (1992). E. Fontain, Application of Genetic Algorithms inthe Field of Constitutional Similarity, J. Chem. Inf, Comput Sci, 32, 748-752, (1992) John H. Holland, Genetic algorithms: computer programs that "evolve" in ways that resemble natural selection can solve complex problems even their creators do not fully understand, Scientific American 267, 66-72 [1992] R.S.Judson, M.E. Colvin, J.C.Meza, A.Huffer, and D.Gutierrez. Do intelligent configuration search techniques outperform random search for large molecules? International Journal of Quantum Chemistry, 44, 277-290, (1992). Richard S. Judson, Teaching Polymers to fold, The Journal of Physical Chemistry, 96(25), 10102, (1992). S. LeGrand and K. Merz, The application of the Genetic Algorithm to the minimization of potential energy functions, J.Global Opt., (1992). Wolfgang Linert, Peter Margl and Istvan Lukovits, Numerical Minimization Procedures in molecular mechanics: structural modelling of the solvation of beta-cyclodextrin, Computers & Chem. 16(1), 61-69, (1992). Marcel J. J. Blommers, Carlos B. Lucasius, Gerrit Kateman and Robert Kaptein, Conformational Analysis of a Dinucleotide Photodimer with the Aid of the Genetic Algorithm, Biopolymers, Vol. 32, 45-52, (1992) R.W. Smith, "Energy minimization in binary alloy models via genetic algorithms" Comput.Phys.Comm. 71, 134-146, (1992). Shaojian Sun, Reduced representation model of protein structure prediction: Statistical potential and genetic algorithms, Protein Science, 2, 762-785, (1993) P. Tuffery, C. Etchebest, S. Hazout, and R. Lavery, A Critical Comparison of Search Algorithms Applied to the Optimization of Protein Side-Chain Conformations, J. Comp. Chem. 14, 790-798, (1993). Ron Unger and John Moult, Genetic Algorithms for Protein Folding Simulations, Journal of Molecular Biology, 231, 75-81, (1993). R. Wehrens, C. Lucasius, L. Buydens, and G. Kateman, Sequential Assignment of 2D-NMR Spectra of Proteins Using Genetic Algorithms, J. Chem. Info. Comput. Sci. 33, 245-251 (1993). Jones, Brown, Clark, Willett and Glen. Searching Databases of Two-Dimensional and Three-Dimensional Chemical Structures Using Genetic Algorithms, in Forest, S. ed., Proceedings of the Fifth International Conference on Genetic Algorithms, Morgan Kaufmann Publishers, San Mateo, CA (1993). R.S. Judson, E. Jaeger, A. Treasurywala, Conformation searching methods for small molecules II: A Genetic algorithm approach, J.Comp.Chem. (1993, in press). D.B. McGarrah and R.S. Judson, An analysis of the genetic algorithm method of molecular conformation determination, J.Comp.Chem. (1993, in press). Clark, Jones, Willett, Glen and Kenny, Pharmacophoric Pattern Matching In Files Of Three-Dimensional Chemical Structures: Comparison Of Conformational-Searching Algorithms For Flexible Searching, Presented at the 3rd Int. conference on Chemical Structures, Journal of Chemical Information and Computer Sciences, (1993, in press). Y.L. Xiao and D.E. Williams, Genetic algorithm: a new approach to the prediction of the structure of molecular clusters, Chem. Phys. Let. (1993, in press) Y.L. Xiao and D.E. Williams, GAME: Genetic algorithm for minimization of energy, an interactive program for three-dimensional intermolecular interactions, Comput. & Chem, (submitted) From raman@bioc01.uthscsa.edu Sat Aug 28 16:05:24 1993 Received: from thorin.uthscsa.edu for raman@bioc01.uthscsa.edu by oscsunb.ccl.net (5.65c+KVa/930601.1506) id AA05209; Sat, 28 Aug 1993 22:04:53 -0400 Received: from bioc01.uthscsa.edu by thorin.uthscsa.edu with SMTP; Sat, 28 Aug 1993 21:05:24 -0500 (CDT) Received: by bioc01.uthscsa.edu (4.1/SMI-4.1) id AA06455; Sat, 28 Aug 93 21:05:25 CDT From: raman@bioc01.uthscsa.edu (C.S.RAMAN) Message-Id: <9308290205.AA06455@bioc01.uthscsa.edu> Subject: Genetic Algorithms To: pcj@psuvm.psu.edu Date: Sat, 28 Aug 1993 21:05:24 -0500 (CDT) Cc: chemistry@ccl.net X-Mailer: ELM [version 2.4 PL3] Content-Type: text Content-Length: 10269 Peter: There was a lengthy discussion on the topic of GA about a month ago on CCL. You might want to FTP to www.ccl.net and grep some of those files to get the full response. I am including my current list of references on GA (dating back to 1989) in order to give you a head start on whatever you are working on. The COSMIC DATABASE (which contains all the programs developed by NASA researchers) contains an interesting algorithm for developing GA applications. I shall describe about this database to the net sometime next week and you can grab the info then. Hope you find this information useful. Cheers -raman *********************************CUT HERE**************************** 1. HIBBERT DB. A HYBRID GENETIC ALGORITHM FOR THE ESTIMATION OF KINETIC PARAMETERS. CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 1993 JUL, V19 N3:319-329. 2. LUCASIUS CB; DEWEIJER AP; BUYDENS LMC; KATEMAN G. CFIT - A GENETIC ALGORITHM FOR SURVIVAL OF THE FITTING. CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 1993 JUL, V19 N3:337-341. 3. JERVIS M; STOFFA PL; SEN MK. 2-D MIGRATION VELOCITY ESTIMATION USING A GENETIC ALGORITHM. GEOPHYSICAL RESEARCH LETTERS, 1993 JUL 23, V20 N14:1495-1498. 4. KUNCHEVA L. GENETIC ALGORITHM FOR FEATURE SELECTION FOR PARALLEL CLASSIFIERS. INFORMATION PROCESSING LETTERS, 1993 JUN 25, V46 N4:163-168. 5. PAYNE AWR; GLEN RC. MOLECULAR RECOGNITION USING A BINARY GENETIC SEARCH ALGORITHM. JOURNAL OF MOLECULAR GRAPHICS, 1993 JUN, V11 N2:74+. 6. BOONE G; CHIANG HD. OPTIMAL CAPACITOR PLACEMENT IN DISTRIBUTION SYSTEMS BY GENETIC ALGORITHM. INTERNATIONAL JOURNAL OF ELECTRICAL POWER & ENERGY SYSTEMS, 1993 JUN, V15 N3:155-162. 7. MATSUURA K; SHIBA H; NUNOKAWA Y; SHIMIZU H; and others. [CALCULATION OF OPTIMAL TRAJECTORIES FOR FERMENTATION PROCESSES BY GENETIC ALGORITHM]. Language: Japanese. SEIBUTSU-KOGAKU KAISHI-JOURNAL OF THE SOCIETY FOR FERMENTATION AND BIOENGINEERING, 1993, V71 N3:171-178. 8. LERICHE R; HAFTKA RT. OPTIMIZATION OF LAMINATE STACKING SEQUENCE FOR BUCKLING LOAD MAXIMIZATION BY GENETIC ALGORITHM. AIAA JOURNAL, 1993 MAY, V31 N5:951-956. 9. FREEMAN LC. FINDING GROUPS WITH A SIMPLE GENETIC ALGORITHM. JOURNAL OF MATHEMATICAL SOCIOLOGY, 1993, V17 N4:227-241. 10. LEVITIN G; RUBINOVITZ J. GENETIC ALGORITHM FOR LINEAR AND CYCLIC ASSIGNMENT PROBLEM. COMPUTERS & OPERATIONS RESEARCH, 1993 AUG, V20 N6:575-586. 11. NARAYANAN MN; LUCAS SB. A GENETIC ALGORITHM TO IMPROVE A NEURAL NETWORK TO PREDICT A PATIENTS RESPONSE TO WARFARIN. METHODS OF INFORMATION IN MEDICINE, 1993 FEB, V32 N1:55-58. 12. JIN S; MADARIAGA R. BACKGROUND VELOCITY INVERSION WITH A GENETIC ALGORITHM. GEOPHYSICAL RESEARCH LETTERS, 1993 JAN 22, V20 N2:93-96. 13. KONAGAYA A. NEW TOPICS IN GENETIC ALGORITHM RESEARCH. Pub type: Editorial. NEW GENERATION COMPUTING, 1992, V10 N4:423-427. 14. WIENKE D; LUCASIUS C; EHRLICH M; KATEMAN G. MULTICRITERIA TARGET VECTOR OPTIMIZATION OF ANALYTICAL PROCEDURES USING A GENETIC ALGORITHM .2. POLYOPTIMIZATION OF THE PHOTOMETRIC CALIBRATION GRAPH OF DRY GLUCOSE SENSORS FOR QUANTITATIVE CLINICAL ANALYSIS. ANALYTICA CHIMICA ACTA, 1993 JAN 18, V271 N2:253-268. 15. PHAM DT; ONDER HH. A KNOWLEDGE-BASED SYSTEM FOR OPTIMIZING WORKPLACE LAYOUTS USING A GENETIC ALGORITHM. Pub type: Note. ERGONOMICS, 1992 DEC, V35 N12:1479-1487. 16. KULKARNI J; PARSAEI HR. INFORMATION RESOURCE MATRIX FOR PRODUCTION AND INTELLIGENT MANUFACTURING USING GENETIC ALGORITHM TECHNIQUES. COMPUTERS & INDUSTRIAL ENGINEERING, 1992 NOV, V23 N1-4:483-485. 17. LANSBERRY JE; WOZNIAK L; GOLDBERG DE. OPTIMAL HYDROGENERATOR GOVERNOR TUNING WITH A GENETIC ALGORITHM. IEEE TRANSACTIONS ON ENERGY CONVERSION, 1992 DEC, V7 N4:623-630. 18. LABOSSIERE P; TURKKAN N. ON THE OPTIMIZATION OF THE TENSOR POLYNOMIAL FAILURE THEORY WITH A GENETIC ALGORITHM. TRANSACTIONS OF THE CANADIAN SOCIETY FOR MECHANICAL ENGINEERING, 1992, V16 N3-4:251-265. 19. VENUGOPAL V; NARENDRAN TT. A GENETIC ALGORITHM APPROACH TO THE MACHINE-COMPONENT GROUPING PROBLEM WITH MULTIPLE OBJECTIVES. COMPUTERS & INDUSTRIAL ENGINEERING, 1992 OCT, V22 N4:469-480. 20. JENKINS WM. PLANE FRAME OPTIMUM DESIGN ENVIRONMENT BASED ON GENETIC ALGORITHM. JOURNAL OF STRUCTURAL ENGINEERING-ASCE, 1992 NOV, V118 N11:3103-3112. 21. LI TH; LUCASIUS CB; KATEMAN G. OPTIMIZATION OF CALIBRATION DATA WITH THE DYNAMIC GENETIC ALGORITHM. ANALYTICA CHIMICA ACTA, 1992 OCT 7, V268 N1:123-134. 22. BHATTACHARJYA AK; BECKER DE; ROYSAM B. A GENETIC ALGORITHM FOR INTELLIGENT IMAGING FROM QUANTUM-LIMITED DATA. SIGNAL PROCESSING, 1992 SEP, V28 N3:335-348. 23. WIENKE D; LUCASIUS C; KATEMAN G. MULTICRITERIA TARGET VECTOR OPTIMIZATION OF ANALYTICAL PROCEDURES USING A GENETIC ALGORITHM .1. THEORY, NUMERICAL SIMULATIONS AND APPLICATION TO ATOMIC EMISSION SPECTROSCOPY. ANALYTICA CHIMICA ACTA, 1992 AUG 14, V265 N2:211-225. 24. PRADOS DL. NEW LEARNING ALGORITHM FOR TRAINING MULTILAYERED NEURAL NETWORKS THAT USES GENETIC-ALGORITHM TECHNIQUES. ELECTRONICS LETTERS, 1992 JUL 30, V28 N16:1560-1561. 25. HAJIMA R; TAKEDA N; OHASHI H; AKIYAMA M. OPTIMIZATION OF WIGGLER MAGNETS ORDERING USING A GENETIC ALGORITHM. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 1992 JUL 1, V318 N1-3:822-824. 26. NARA K; DEB AK; SHIOSE A; KITAGAWA M; and others. IMPLEMENTATION OF GENETIC ALGORITHM FOR DISTRIBUTION SYSTEMS LOSS MINIMUM RECONFIGURATION. IEEE TRANSACTIONS ON POWER SYSTEMS, 1992 AUG, V7 N3:1044-1051. 27. KOPFER H. [PROGENITOR - A GENETIC ALGORITHM FOR PRODUCTION SCHEDULING]. Language: German. Pub type: Letter. WIRTSCHAFTSINFORMATIK, 1992 APR, V34 N2:255-256. 28. KANET JJ; SRIDHARAN V. PROGENITOR - A GENETIC ALGORITHM FOR PRODUCTION SCHEDULING - REPLY. Pub type: Letter. WIRTSCHAFTSINFORMATIK, 1992 APR, V34 N2:256-256. 29. TOKINAGA S; WHINSTON AB. APPLYING ADAPTIVE CREDIT ASSIGNMENT ALGORITHM FOR THE LEARNING CLASSIFIER SYSTEM BASED UPON THE GENETIC ALGORITHM. IEICE TRANSACTIONS ON FUNDAMENTALS OF ELECTRONICS COMMUNICATIONS AND COMPUTER SCIENCES, 1992 MAY, VE75A N5:568-577. 30. MICHALEWICZ Z; JANIKOW CZ; KRAWCZYK JB. A MODIFIED GENETIC ALGORITHM FOR OPTIMAL CONTROL PROBLEMS. COMPUTERS & MATHEMATICS WITH APPLICATIONS, 1992 JUN, V23 N12:83-94. 31. ABDULLAH AR. A ROBUST METHOD FOR LINEAR AND NONLINEAR OPTIMIZATION BASED ON GENETIC ALGORITHM. CYBERNETICA, 1991, V34 N4:279-287. 32. GEMMILL DD. SOLUTION TO THE ASSORTMENT PROBLEM VIA THE GENETIC ALGORITHM. MATHEMATICAL AND COMPUTER MODELLING, 1992 JAN, V16 N1:89-94. 33. BLOMMERS MJJ; LUCASIUS CB; KATEMAN G; KAPTEIN R. CONFORMATIONAL ANALYSIS OF A DINUCLEOTIDE PHOTODIMER WITH THE AID OF THE GENETIC ALGORITHM. BIOPOLYMERS, 1992 JAN, V32 N1:45-52. 34. WILSON WG; VASUDEVAN K. APPLICATION OF THE GENETIC ALGORITHM TO RESIDUAL STATICS ESTIMATION. GEOPHYSICAL RESEARCH LETTERS, 1991 DEC, V18 N12:2181-2184. 35. MUHLENBEIN H; SCHOMISCH M; BORN J. THE PARALLEL GENETIC ALGORITHM AS FUNCTION OPTIMIZER. PARALLEL COMPUTING, 1991 SEP, V17 N6-7:619-632. 36. KANET JJ; SRIDHARAN V. PROGENITOR - A GENETIC ALGORITHM FOR PRODUCTION SCHEDULING. WIRTSCHAFTSINFORMATIK, 1991 AUG, V33 N4:332-336. 37. WANG QJ. THE GENETIC ALGORITHM AND ITS APPLICATION TO CALIBRATING CONCEPTUAL RAINFALL-RUNOFF MODELS. WATER RESOURCES RESEARCH, 1991 SEP, V27 N9:2467-2471. 38. JENKINS WM. TOWARDS STRUCTURAL OPTIMIZATION VIA THE GENETIC ALGORITHM. Pub type: Note. COMPUTERS & STRUCTURES, 1991, V40 N5:1321-1327. 39. BOS M; WEBER HT. COMPARISON OF THE TRAINING OF NEURAL NETWORKS FOR QUANTITATIVE X-RAY FLUORESCENCE SPECTROMETRY BY A GENETIC ALGORITHM AND BACKWARD ERROR PROPAGATION. ANALYTICA CHIMICA ACTA, 1991 JUN 14, V247 N1:97-105. 40. VIGNAUX GA; MICHALEWICZ Z. A GENETIC ALGORITHM FOR THE LINEAR TRANSPORTATION PROBLEM. Pub type: Letter. IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS, 1991 MAR-APR, V21 N2:445-452. 41. COOK DF; WOLFE ML. GENETIC ALGORITHM APPROACH TO A LUMBER CUTTING OPTIMIZATION PROBLEM. CYBERNETICS AND SYSTEMS, 1991 MAY-JUN, V22 N3:357-365. 42. GORDON MD. USER-BASED DOCUMENT CLUSTERING BY REDESCRIBING SUBJECT DESCRIPTIONS WITH A GENETIC ALGORITHM. JOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE, 1991 JUN, V42 N5:311-322. 43. MAHLAB U; SHAMIR J; CAULFIELD HJ. GENETIC ALGORITHM FOR OPTICAL PATTERN RECOGNITION. OPTICS LETTERS, 1991 MAY 1, V16 N9:648-650. 44. SUCKLEY D. GENETIC ALGORITHM IN THE DESIGN OF FIR FILTERS. IEE PROCEEDINGS-G CIRCUITS DEVICES AND SYSTEMS, 1991 APR, V138 N2:234-238. 45. KOHLER HM. ADAPTIVE GENETIC ALGORITHM FOR THE BINARY PERCEPTRON PROBLEM. Pub type: Letter. JOURNAL OF PHYSICS A-MATHEMATICAL AND GENERAL, 1990 DEC 7, V23 N23:L1265-L1271. 46. BICKEL AS; BICKEL RW. DETERMINATION OF NEAR-OPTIMUM USE OF HOSPITAL DIAGNOSTIC RESOURCES USING THE GENES GENETIC ALGORITHM SHELL. COMPUTERS IN BIOLOGY AND MEDICINE, 1990, V20 N1:1-13. -- C.S.Raman raman@bioc01.uthscsa.edu - Internet UNIX Programming & Administration 70412.2354@compuserve.com - CIS SPARC & SGI Systems raman@hermes.chpc.utexas.edu - CHPC Department of Biochemistry c.raman@launchpad.unc.edu UTHSCSA 7703 Floyd Curl Dr. (210) 567-6623 [Tel] San Antonio, TX 78284-7760 (210) 567-6595 [Fax] ****************************************************************************** If a man's wit be wandering, let him study the Mathematics -Francis Bacon ******************************************************************************