From ETLOO@WSUHUB.UC.TWSU.EDU Fri Nov 11 01:25:32 1994 Received: from WSUHUB.UC.TWSU.EDU for ETLOO@WSUHUB.UC.TWSU.EDU by www.ccl.net (8.6.9/930601.1506) id BAA28010; Fri, 11 Nov 1994 01:24:10 -0500 From: Received: from WSUHUB.UC.TWSU.EDU by WSUHUB.UC.TWSU.EDU (PMDF V4.3-9 #6497) id <01HJC0LZJDR4C7KITQ@WSUHUB.UC.TWSU.EDU>; Fri, 11 Nov 1994 00:24:54 -0600 (CST) Date: Fri, 11 Nov 1994 00:24:54 -0600 (CST) Subject: request for info on careers in chemistry To: chemistry@ccl.net, chemistry-request@oscsunb.ccl.net Message-id: <01HJC0LZKGC2C7KITQ@WSUHUB.UC.TWSU.EDU> X-VMS-To: IN%"chemistry@ccl.net",IN%"chemistry-request@oscsunb.ccl.net" MIME-version: 1.0 Content-type: TEXT/PLAIN; CHARSET=US-ASCII Content-transfer-encoding: 7BIT Name : Eric T. Loo Affiliation : Wichita State University E-mail address: etloo@wsuhub.uc.twsu.edu I need some information about jobs opportunity in chemistry for students with Bsc in Chemistry (undergraduate). From peeter@chem.ut.ee Fri Nov 11 04:26:12 1994 Received: from Tera for peeter@chem.ut.ee by www.ccl.net (8.6.9/930601.1506) id DAA29312; Fri, 11 Nov 1994 03:58:39 -0500 Received: by Tera (Linux Smail3.1.28.1 #1) id m0r5rqs-00022AC; Fri, 11 Nov 94 11:00 EET Message-Id: From: peeter@chem.ut.ee (Peeter Burk) Subject: Compiling iglo92 on SGI To: CHEMISTRY@ccl.net Date: Fri, 11 Nov 1994 11:00:58 +0200 (EET) Reply-To: peeter@chem.ut.ee X-Mailer: ELM [version 2.4 PL23] Content-Type: text Content-Length: 758 Dear all, Have somebody gotten the program iglo92 running on SGI Indigo2? I have tried hard for some time, but still have big problems - the program compiles neatly, but then the results are very different from those supplied with program (or obtained on Convex). The differences began from the number of integrales writen out. I have tried different compiler options e.g. -static, -r8 etc. but so far with no success. So I would appreciate any suggestions. Best regards, Peeter -- Peeter Burk, Ph.D. Jakobi 2, EE2400 Tartu, Estonia Institute of Chemical Physics Phone (372-7) 441-453 Tartu University Fax (372-7) 441-453 Estonia E-mail peeter@chem.ut.ee From steller@structchem.uni-essen.de Fri Nov 11 04:34:23 1994 Received: from gaby.structchem.uni-essen.de for steller@structchem.uni-essen.de by www.ccl.net (8.6.9/930601.1506) id EAA29377; Fri, 11 Nov 1994 04:18:38 -0500 Received: by gaby.structchem.uni-essen.de (911016.SGI/910805.SGI) for chemistry@oscsunb.ccl.net id AA07323; Fri, 11 Nov 94 10:18:37 +0100 From: steller@structchem.uni-essen.de (Ingo Steller) Message-Id: <9411110918.AA07323@gaby.structchem.uni-essen.de> Subject: Re: SHELX/PC To: chemistry@oscsunb.ccl.net (Chemistry-Mailinglist) Date: Fri, 11 Nov 1994 10:18:36 +0100 (MET) X-Mailer: ELM [version 2.4 PL21] Content-Type: text Content-Length: 765 #see these are not for the PC. SHELX/XP can display molecules on the PC but #as far as I know it is slow, cumbersome and Red/blue display(?). As far as I know SHELX/XP is a MS-DOS program (not Windows) that is really fast in rotating molecules in red/blue stereo-view. You also can show the crystal structures in an ORTEP-like way and some other ways. Unfortunately the program is only available commercially from SIEMENS. Ingo Steller -- Ingo Steller e-mail: steller@structchem.uni-essen.de Universitaet-Gesamthochschule Essen Fachbereich 08 - Chemie Tel.: ++49 (0)201 183 3599 Institut fuer Anorganische Chemie Fax : ++49 (0)201 183 2535 Abteilung Roentgenstrukturanalyse Universitaetsstrasse 3-5 45117 Essen From WANG@IRBM.IT Fri Nov 11 08:25:41 1994 Received: from V1.IRBM.IT for WANG@IRBM.IT by www.ccl.net (8.6.9/930601.1506) id IAA01186; Fri, 11 Nov 1994 08:24:40 -0500 From: Date: Fri, 11 Nov 1994 14:25:58 +0100 (WET) To: chemistry@ccl.net CC: WANG@IRBM.IT, "mmod@still3.chem.columbia.edu"@ccl.net Message-Id: <941111142558.7505@IRBM.IT> Subject: Macromodel_Amber charges: Summary Dear all, I greatly appreciate the replies from Drs. Dave Case, Xinjun Hou and Peter Shenkin. My initial posting reads: > AMBER force field in Macromodel 4.5 gives guanine (also C, T and U) a > net charge of -0.236. Does anyone have the same experience with other > molecules ? Here is the summary: AMBER force field has not been designed (at least Amber* in Macromodel 4.5) for nucleoside analogues (i.e., molecules with substructures of normal natural nucleoside bases). If one prefer Amber force field for modeling nucleoside analogues, one may use his/her own charges or "borrow" the charges from other force fields. An alternative is to derive ESP-fitted charges with Gaussian 92 or Mopac (I think a new option, QPMEP, will be included in the 95 version). Since the native ESP charges are usually not averaged by either global or local symmetry, caution may not be extravagant about the geometrical optimization with a large scale of rotations, e.g. conformational analysis. Below are the responses I received. Ciao, Bingze Wang, Ph.D. ===================================================================== Date: Tue, 8 Nov 94 17:49:54 PST From: case@scripps.edu (David Case) To: WANG@IRBM.IT Subject: Re: CCL:Macromodel_Amber charges "guanine" by amber nomeclature is only a fragment of a molecule, which needs to be linked to something else, usually phosphates of a nucleic acid backbone or something. I think if you want to make guanosine, you may need to add h5' and h3' hydrogens, [or something like that]. ...dave case ===================================================================== Date: Wed, 9 Nov 94 09:33:14 -0800 From: hou@agouron.com (Xinjun Hou) To: WANG@IRBM.IT Subject: Re: CCL:Macromodel_Amber charges Hi Bingze: >AMBER force field in Macromodel 4.5 gives guanine (also C, T and U) a >net charge of -0.236. Does anyone have the same experience with other >molecules ? I have not seen such case yet, unless there is a substructure definition in your force field which matches your structure partially and also defines the charges. I would be intereted to know the answer too! Xinjun C Xinjun J. Hou (hou@agouron.com) Voice: 619-622-3000 C Agouron Pharmaceuticals, Inc. San Diego, CA 92121 ===================================================================== Date: Wed, 9 Nov 94 10:39:44 -0800 From: hou@agouron.com (Xinjun Hou) To: WANG@IRBM.IT Subject: Re: CCL:Macromodel_Amber charges >I am waiting for your answer. Bingze: As expected, the total charges I got is -0.236 for guanine (2-amino-6-hydorxypurine only) I think that this is because macromodel takes guanine as part of a ribose monophosphate form. If you make a complete structure by going to "INPUT-NUCLEI-GU", you will see why Xinjun C Xinjun J. Hou (hou@agouron.com) Voice: 619-622-3000 C Agouron Pharmaceuticals, Inc. San Diego, CA 92121 C10110000110100101101110011010100111010101101110010010000110111101110101 ===================================================================== From: "Peter Shenkin" Date: Wed, 9 Nov 1994 12:29:12 -0500 To: Subject: Re: CCL:Macromodel_Amber charges Cc: mmod@still3.chem.columbia.edu Could you email me a .dat, .com and .log file exhibiting this problem? I will look into it and let you know what I find. Technical questions or difficulties about MacroModel are best addressed to "mmod@still3.chem.columbia.edu". -P. -- *"Voters prefer the bandwagon to the burning deck" (V. Bonham Carter)* *Peter S. Shenkin, Box 768 Havemeyer Hall, Chemistry, Columbia Univ.,* * New York, NY 10027; shenkin@columbia.edu; (212) 854-5143 * ** "Illegal immigrants make the best nannies" (Your Congressperson) ** ===================================================================== From: "Peter Shenkin" Date: Thu, 10 Nov 1994 18:06:51 -0500 To: Subject: Re: CCL:Macromodel_Amber charges Cc: mmod@still3.chem.columbia.edu, chemistry@ccl.net Mr. Wang, The charges you obtained were put into the forcefield directly from Kollman's 1984 paper. They are designed for use in the context of ribo- or deoxyribonucleic acids. When they are used in this context, the sugar has a net charge of +0.236, which balances the net charge of -0.236 on the base. Thus, these substructures must be used in the proper context in order for the charges to make sense. I have to say that I am not completely happy with this situation. I think that we should not really have charge substructures in our force-field file that correspond to neutral species, because this can lead to funny side-effects, such as you observe, when not used in the proper context. Perhaps we should really have, for example, guanine-ribose and guanine-deoxyribose in the force-field as substructures. These overall substructures would be neutral. Of course, in this situation, plain old guanine, with no sugar, would not be matched by a special substructure, and would not be given high-quality parameters unless someone went out and derived them from QM calculations. Certainly, as implied by my discussion above, the parameters given for guanine are appropriate to guanine only with ribose or deoxyribose attached, and not to isolated guanine. We will consider altering the force-field to remove things like guanine, and put them back in attached to the appropriate sugars. This will not give you good parameters if what you really want to model is isolated guanine, but good parameters for isolated guanine do not, I beleve, exist in standard AMBER. If they exist in the literature, or if someone does a credible job of deriving them, we'd be happy to add them to MacroModel's AMBER* forcefield. -P. -- *"Voters prefer the bandwagon to the burning deck" (V. Bonham Carter)* *Peter S. Shenkin, Box 768 Havemeyer Hall, Chemistry, Columbia Univ.,* * New York, NY 10027; shenkin@columbia.edu; (212) 854-5143 * ** "Illegal immigrants make the best nannies" (Your Congressperson) ** =================== That's all. Thanks for your time ================== From stoutepf@chemsci1.es.dupont.com Fri Nov 11 09:25:38 1994 Received: from gatekeeper.es.dupont.com for stoutepf@chemsci1.es.dupont.com by www.ccl.net (8.6.9/930601.1506) id JAA02072; Fri, 11 Nov 1994 09:22:09 -0500 Received: by gatekeeper.es.dupont.com; id AA29672; Fri, 11 Nov 94 09:22:07 -0500 Received: from [138.196.64.95] (chem95.es.dupont.com) by chemsci1.es.dupont.com (4.1/SMI-4.1) id AA08911; Fri, 11 Nov 94 09:19:07 EST Message-Id: <9411111419.AA08911@chemsci1.es.dupont.com> Mime-Version: 1.0 Content-Type: text/plain; charset="us-ascii" Reply-To: stoutepf@chemsci1.es.dupont.com X-Organization: The Du Pont Merck Pharmaceutical Company X-Mailer: Eudora 1.4 Date: Fri, 11 Nov 1994 09:22:00 -0500 To: tudor@t10.Lanl.GOV (Tudor Oprea) From: stoutepf@chemsci1.es.dupont.com (Pieter Stouten) Subject: Re: program GALAXY & QSAR Cc: chemistry@ccl.net >But more often than not, people not >familiar with QSAR call it QUASAR. > >The connection between the QSAR program GALAXY and astronomy >becomes dangerously close 8=) > A dangerous association indeed as astronomy is a hard science whereas the "Q" in QSAR stands for "quasi" as we all know :-). Pieter Stouten, Senior Research Scientist || Computer Aided Drug Design Group || The Du Pont Merck Pharmaceutical Company || Adventures get spoiled P.O. Box 80353, Wilmington, DE 19880-0353 || by being reduced to data Phone: +1 (302) 695 3515 || -- Fax: +1 (302) 695 2813 || Poul Anderson E-mail: stoutepf@chemsci1.es.dupont.com || Internet Shogi Server: kzinti || From ZAHAREVITZ@dtpax2.ncifcrf.gov Fri Nov 11 09:45:21 1994 Received: from dtpax2.ncifcrf.gov for ZAHAREVITZ@dtpax2.ncifcrf.gov by www.ccl.net (8.6.9/930601.1506) id IAA01489; Fri, 11 Nov 1994 08:51:06 -0500 Date: Fri, 11 Nov 1994 8:52:11 -0500 (EST) From: Dan Zaharevitz 301-496-8747 To: chemistry@ccl.net CC: ZAHAREVITZ@dtpax2.ncifcrf.gov Message-Id: <941111085211.20207856@dtpax2.ncifcrf.gov> Subject: NCI structure database There are several possibilities for obtaining structural infomation from NCI. There is a set of about 125,000 connection tables in MDL's MACCS format. This set is available via anonymous ftp from helix.nih.gov anonymous ftp to helix.nih.gov cd ncidata/2D In this directory there should be 3 files including a .readme file. The connection table file is compressed with the standard UNIX compress. It takes up about 11 Meg compressed and expands to about 190 Meg. This file contains only the connection table, no coordinates ( 2D or 3D ) are available. If you don't want to build a database from connection tables, you should contact the vendor of your database software. All the companies I know of have been made aware of the availability of these connection tables and I think most have built a database with them. The NCI has had no involvement in these database builds and also has no control of how much money the companies charge for providing the database. At the NCI we have used Chem-X from Chemical Design to build databases from connection tables. Details have been published: Milne, et. al. J. Chem. Info. Comput. Sci. 34:1219-1224(1994) There is also a WWW page that contains very detailed information on how we build and search databases. The URL is: http://www.nih.gov/molecular_modeling/dis_documents/dis3d.html The availability of biological data is under discussion. One of the big concerns is how to make the data available in a form that is useful to people, but doesn't require a lot of support from the NCI staff ( resources are tight ). The WWW page experiment has gotten some positive responses and there should soon be the start of efforts to make some biological data available over the net. I'll try to announce when these attempts come online and would greatly appreciate comments and criticisms. If you have any questions feel free to contact me. DanZ. /********************************************************************** * Dan Zaharevitz * Information Technology Branch, Developmental Therapeutics Program * National Cancer Institute * EPN Room 811, 6130 Executive Blvd. Rockville, MD 20892-9903 * email: zaharevitz@dtpax2.ncifcrf.gov phone: (301)496-8747 **********************************************************************/ From LONGO@NPD.UFPE.BR Fri Nov 11 11:25:42 1994 Received: from npd1.npd.ufpe.br for LONGO@NPD.UFPE.BR by www.ccl.net (8.6.9/930601.1506) id KAA02875; Fri, 11 Nov 1994 10:46:16 -0500 From: Received: from NPD.UFPE.BR by NPD.UFPE.BR (PMDF V4.2-11 #6339) id <01HJCPM53GRK8WWE2L@NPD.UFPE.BR>; Fri, 11 Nov 1994 12:21:52 -0300 Date: Fri, 11 Nov 1994 12:21:52 -0300 Subject: Lewis A-B To: CHEMISTRY@ccl.net Message-id: <01HJCPM549PE8WWE2L@NPD.UFPE.BR> X-VMS-To: IN%"CHEMISTRY@ccl.net" MIME-version: 1.0 Content-type: TEXT/PLAIN; CHARSET=US-ASCII Content-transfer-encoding: 7BIT Dear Netters, I'd appreciate any references, comments or suggestions on the semiempirical performance (MNDO, AM1, PM3) for structure and energetics of Lewis Acids (BH3, BF3, SnCl4...) - Bases (CO, NH3, RCO...) interactions. Thanks a lot. Ricardo Longo longo@npd1.npd.ufpe.br Departamento de Quimica Fundamental UFPE, Recife, Brazil From janrad@tiger.chem.uw.edu.pl Fri Nov 11 15:25:43 1994 Received: from tiger.chem.uw.edu.pl for janrad@tiger.chem.uw.edu.pl by www.ccl.net (8.6.9/930601.1506) id OAA05272; Fri, 11 Nov 1994 14:32:28 -0500 Received: by tiger.chem.uw.edu.pl (AIX 3.2/UCB 5.64/4.03) id AA15581; Fri, 11 Nov 1994 20:32:17 +0100 Date: Fri, 11 Nov 1994 20:32:17 +0100 From: janrad@tiger.chem.uw.edu.pl (Jan Radomski) Message-Id: <9411111932.AA15581@tiger.chem.uw.edu.pl> To: chemistry@ccl.net Subject: SUMMARY: computer searchable structural & spectral databases (long) Cc: janr@tiger.chem.uw.edu.pl --- Dear All, about two weeks ago I've posted query about computer searchable structural & spectral databases. And then few days latter more detailed one about spec- tral databases only. Here are all responses. Like one of you mentioned this subject wasn't discussed lately very much; before querrying I was through CCL archives. Despite obvious usefulness of such databases there was not much info sent to me. Especially the querry about spectroscopic databases have drawn complete blank. Maybe I should formulate it differently? Like I'm mostly interested in spectral data of all kinds. Acommpanying software to search these data are of less importance, though of course one would like to have it too. Many thanks to all of you who replied, and especially Yvonne Martin and Nanette Butterworth sincerely, Jan Radomski First my own questions: =========================================================================== Date: Thu, 27 Nov 1994 23:01:29 +0100 From: janrad@tiger.chem.uw.edu.pl (Jan Radomski) Subject: CCL: computer searchable structural & spectral databases ---- Dear Netters, I am interested in contact with anyone willing to share their experience on acquiring, installing, running, etc. any kind of spectral, structural, QSAR, safety or any other chemical and material sciences computer database. Public domain, shareware as well as commercial. Of special interest are ease of use, availability of internal data formats, ASCII exports, portability, and of course cost. Please e-mail me direct, I'll summarize for the net if there would be suf- ficient interest. Jan Radomski ========================================================================== Date: Thu, 3 Nov 1994 03:36:25 +0100 From: janrad@tiger.chem.uw.edu.pl (Jan Radomski) Subject: CCL:spectral databases ---- Dear Netters, in two quite recent review articles in Analytical Chemistry (vol. 65, 1045A-1050A; vol. 65, 1087A-1095A) Wendy A. Warr lists several NMR, IR and MS spectral databases. Most if not all of them are meant to be used on small computers, PCs & Macs. This is perhaps a good choice for interactive work close to bench or spectrometer, but for other applications poses rather severe limitation. I'd appreciate very much any comment about hands-on experience or familiarity with the databases listed below. Of special interest are ease of use, availability of internal data formats, ASCII exports, and most of all portability to UNIX. Please e-mail me direct, I'll summarize for the net. Thanks in advance, Jan Radomski NMR spectral databases: source/vendor ## of 13C 1H other nuclei SADTLER (on PC) 34000 - - -"- CSEARCH 60000 - - SpecInfo 99000 830 13700 NIMCR Japan 8000 11000 - Preston Scientific - - 10000 19F 1300 other Bruker 19000 9000 - Tsukuba Univ. Japan polymer spectra on CD-ROM IR and FT-IR: source/vendor ## spectra remarks SADTLER 160000 (mostly FTIR) -"- vapor phase 9200 FTIR Aldrich-Nicolet 17000 FTIR Sigma-Nicolet 10600 FTIR Aldrich vapor phase 5000 FTIR NIST/EPA vp 5250 FTIR SpecInfo 22600 17000 digitized 5600 peak/intensity list NIMCR Japan 46400 FTIR Coblenz S-ciety 10500 4400 digitized IRDC Japan 19000 peak/intensity list only all IR spectra with accompanying structures. MS: source/vendor # spectra # compounds # structures Wiley 139859 118144 91529 NIST/EPA/NIH >70000 65000 65000 +32000 duplicates SpecData 150000 150000 ? 150000 ? NIMCR Japan 16300 16300 ? ? JICST/ MS Society of Japan 6000 6000 ? CAS Reg.# Jan Radomski and all replies ============================================================================= Date: Fri, 28 Oct 1994 16:56:29 -0500 (CDT) From: Marc Guy Decaire ------ Hi. I read your message about the fact that you were making a list of spectroscopy/structures databases. I saw the message on the CCL list. When you're finished with it, could you email me a copy? Thankyou Marc DeCaire umdecai0@CC.UManitoba.CA ============================================================================ From: kcousins@wiley.csusb.edu (Kimberley Cousins) Date: Sat, 29 Oct 1994 00:54:41 -0700 (PDT) ---- Jan, This subject has not been dicussed much in the last 1.5 yrs. I would be interested in a summary of your responses. Kimberley Cousins Department of Chemistry California State University, San Bernardino 5500 University Parkway San Bernardino, CA 92407 (909)880-5391 kcousins@wiley.csusb.edu =========================================================================== Date: Sat, 29 Oct 1994 13:43:08 -0400 (EDT) From: "William T. Winter" ----- I recommend you contact Dave Kristofferson via biosci-help@net.bio.net He has been involved with this for some years with thanks like genome project and protein sequence databases. =-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-= Dr. William T. Winter Phone: (315)470-6876 315 Baker Lab FAX: (315)470-6856 SUNY-ESF Internet: wtwinter@mailbox.syr.edu Syracuse, NY 13210-2786 ========================================================================== Date: Sat, 5 Nov 94 11:51:52 PST From: ---- > on acquiring, installing, running, etc. any kind of spectral, structural, > QSAR, safety or any other chemical and material sciences computer database. > Public domain, shareware as well as commercial. I have no experience with the above. Sincerely, Dave Kristofferson BIOSCI/bionet Manager biosci-help@net.bio.net ========================================================================= Date: Fri, 28 Oct 1994 12:26:19 -0500 (CDT) From: MARTIN%cmda@randb.abbott.com ---- We are big users of Daylight databases. Information is stored on a "page" associated with a particular chemical structure. The neat thing about it is that it has a wonderful toolkit that allows one to tie chemical knowledge to a particular structure. There are also tools for showing the 2D or 3D(if stored) structure, for making postscript output, and for doing ordinary things such as chemical structure look-ups from "names" or sub- and super-structure searching in record time (everything is kept in memory). The Da in Daylight is from Dave Weininger, the inventor of the SMILES line notation and associated uniquification & hashing routines. All the new stuff is Unix based. There are tool-kits for making Mac or PC programs that call the Unix programs. Yvonne Martin Abbott Laboratories ========================================================================== Date: Fri, 28 Oct 94 17:04:03 EST From: nxb96@acs.org (Nanette Butterworth) ---- Jan, Please send your complete address and I will send you a catalog of 80 or so programs peer-reviewed by ACS. This includes several packages in the categories you mentioned in your inquiry. Good Luck! NB From wendy@cumbnd.bioc.columbia.edu Fri Nov 11 16:25:43 1994 Received: from cumbnd.bioc.columbia.edu for wendy@cumbnd.bioc.columbia.edu by www.ccl.net (8.6.9/930601.1506) id QAA05993; Fri, 11 Nov 1994 16:12:07 -0500 Received: from cumbna by cumbnd.bioc.columbia.edu (NX5.67d/NX3.0M) id AA08953; Fri, 11 Nov 94 17:11:54 -0400 From: Wendy Chen Message-Id: <9411112111.AA08953@cumbnd.bioc.columbia.edu> Received: by cumbna.bioc.columbia.edu (NX5.67d/NX3.0X) id AA10909; Fri, 11 Nov 94 16:11:31 -0500 Date: Fri, 11 Nov 94 16:11:31 -0500 Received: by NeXT.Mailer (1.95) Received: by NeXT Mailer (1.95) To: chemistry@ccl.net Subject: Focus on Microscopy 1995 Begin forwarded message: To: str-nmr@net.bio.net From: liao@acsu.buffalo.edu (Jui-Ping Liao) Subject: Focus on Microscopy 1995 Sender: nntp@acsu.buffalo.edu Nntp-Posting-Host: autarch.acsu.buffalo.edu Date: Fri, 11 Nov 1994 16:57:31 GMT FOCUS ON MICROSCOPY 95 A joint meeting of 8th International Conference on 3D Image Processing in Microscopy and 7th International Conference on Confocal Microscopy April 18-20, 1995 Howard Plaza Hotel, Taipei, Taiwan, Rep. of China CALL FOR PAPERS _________________________________________________________________ SCIENTIFIC PROGRAM Scientific sessions start on Tuesday, April 18, 1995. Original contributions will be presented in the following areas: Confocal microscopy * theory of confocal imaging * scanning confocal designs: point / slit arrangements, beam scanning, direct field scanning (bilateral, tandem) * high resolution optical 3-D Microscopy * two photon and time resolved fluorescence imaging * transfer functions and deconvolution Applications * confocal microscopy in-vivo: approaches, problems and prospects * 3D imaging for agricultural research * fluorescence 3-D imaging in cell biology and neurobiology * fluorescent probes, in-situ hybridization * 3-D cytometry * microstructures of materals, polymers and thin films * application in environmental sciences Near-field microscopy * near-field scanning techniques (NSOM, STM, AFM) * high resolution DNA - imaging * spectroscopy and surface modification * combined near-field and confocal designs Optical tweezers and scalpel * instrumentation * applications Electron Microscopy * cryo-microscopy * low-voltage SEM * electron beam tomography X-ray microscopy * theory and instrumentation of x-ray microscopy * x-ray sources 3-D imaging processing * 3-D reconstruction of histological, optical and tomographical sections * visualization models in 3-D and 4-D microscopy * supercomputing in microscopy * analysis of serial section images, 3-D scene recognition * 3-D image restoration and image quality CONTRIBUTION AND PUBLICATION OF EXTENDED ABSTRACTS Papers are invited for oral and poster presentation from the fields indicated by the scientific program and related areas. Deadline for submission of abstracts is December 31, 1994. An extented abstract (minimum 700 words and maximum 1500 words) is required for each presentation, and will be published as a suplement issue of Zoological Studies (ISSN 1021-5506). All text will be typeset by the publisher. Authors are encouraged to submit their manuscript in electronic forms. Files created from the following word processos are acceptable, otherwise, please submit your manuscript in ASCII form (both Mac and IBM-PC format). Manuscript can also be submitted by e-mail to: elepcc@ ubvms.cc buffalo.edu, however, a hardcopy has to be sent by mail (or faxed) to the address in USA. A hardcopy is required accompany the electronic form. Mac Word, Wordstar, Word Perfect, Microsoft Word, Ventura, ASCII Figures and photos are permitted, however they have to fit the following format specified in the photo and diagram format guide for direct photoreproduction. Original photographs (both B&W and color) and line drawings are required. If it is possible, authors please provide a FAX number to facilatate the transmission of galley proof in early 1995. The organizing committee will make a selection of the abstracts for oral presentation. By the end of January 1995 authors will be notified about acceptance and the final program will be mailed to all registrants. ACCOMMODATION The Howard Plaza Hotel provides subtantially reduced room rates for conference participants of Focus on Microscopy '95. Hotel Accommodation at the Howard Plaza Hotel is offered on a first come, first served basis. Please refer to Focus on Microscopy '95 for qualifying the reduced room rates at booking: (refer to Registration form) Howard Plaza Hotel 160 Jen Ai Road, Sec. 3 Taipei, Taiwan, Republic of China Phone: 886-2-700-2323 FAX: 886-2-700-0729 The room rate includes 10% service charge, welcome wine, fruit basket, newspaper and the use of health club facilities including sauna. Major credit cards (American Express, Visa, Mastercard, JCB, Diners Club) are accepted at the hotel. REGISTRATION & CONFERENCE FEE The conference fee is US$220, which includes, documentation, abstract book and refreshments during breaks. A preregistration fee of US$180.00, is available when postmarked before January 31, 1995. OFFICIAL AIR CARRIER China Airlines is the official air carrier of Focus on Microscopy 95, special discount airfare is available through CAL's world wide branch offices. INFORMATION Registration, abstract forms and enquires: N. America and Europe: Focus on Microscopy '95 c/o Dr. P. C. Cheng Advanced Micrscopy and Imaging Laboratory Department of Electrical and Computer Engineering State University of New York at Buffalo P.O. Box. 84 Getzville, NY 14068 USA Tel and Fax: 716-645-3868 e-mail: elepcc@corn.eng.buffalo.edu Other nations: Focus on Microscopy '95 c/o Dr. J. L. Wu Institute of Zoology Academia Sinica Nankang, Taipei, Taiwan 11529 Republic of China Tel: 886-2-789-9500 Fax: 886-2-789-9503/886-2-785-8059 e-mail: zojlwu@ccvax.sinica.edu.tw ORGANIZERS C.P. Chen (Taipei) G.J. Brakenhoff (Amsterdam) A.Kriete (Giessen) C.H. Chou (Taipei) P. C. Cheng (Buffalo)(Chairman) C.J.R. Sheppard (Sydney) P.P. Hwang (Taipei) C. Cogswell (Sydney) D.M.Shinozaki (London,Cana da) W.Y. Lee (Taipei) M. Gu (Sydney) E.H.K. Stelzer (Heidelberg ) H.K. Wu (Taipei) V. Howard (Liverpool) T. Wilson (Oxford) J.L. Wu (Taipei) H. Kim (Rochester) W.L. Wu (Taipei) _________________________________________________________________ THE CONFERENCE IS JOINTLY O RGANIZED AND SUPPORTED BY The Society for 3-D Imaging Sciences in Microscopy, Amsterdam Institute of Zoology, Academia Sinica, Taiwan, R.O.C. Electron Microscopy Society of China, Taipei, R.O.C. Life Science Research Promotion Center, NSC, R.O.C. AMIL, State University of New York at Buffalo, U.S.A. _________________________________________________________________