From asnani@giaspn01.vsnl.net.in Thu Apr 11 01:45:52 1996 Received: from giaspn01.vsnl.net.in for asnani@giaspn01.vsnl.net.in by www.ccl.net (8.7.1/950822.1) id BAA14482; Thu, 11 Apr 1996 01:16:38 -0400 (EDT) Received: by giaspn01.vsnl.net.in; (5.65v3.2/1.1.8.2/20Feb96-0821PM) id AA15149; Thu, 11 Apr 1996 10:53:19 +0500 Date: Thu, 11 Apr 1996 10:53:19 +0500 (GMT+0500) From: GC Asnani To: CHEMISTRY@www.ccl.net Cc: asnani@giaspno1.vsnl.net.in Subject: Information about access sites. Message-Id: Mime-Version: 1.0 Content-Type: TEXT/PLAIN; charset=US-ASCII Sir, I would like to request you to provide me information about access sites for the following key words; Atomic structure, Nuclear structure, Molecular Geometry, Chiraity, bond dissymmetry, Nuclear Magnetism, Isotopes, Isomerism, . I would be grateful to you if you provide me this information on my e-mail No. asnani@giaspno1.vsnl.net.in Thanking you, Prof. G.C. Asnani. From toukie@zui.unizh.ch Thu Apr 11 02:45:53 1996 Received: from rzusuntk.unizh.ch for toukie@zui.unizh.ch by www.ccl.net (8.7.1/950822.1) id BAA14653; Thu, 11 Apr 1996 01:57:57 -0400 (EDT) Received: by rzusuntk.unizh.ch (4.1/SMI-4.1.9) id AA25067; Thu, 11 Apr 96 07:57:48 +0200 X-Nupop-Charset: Swiss Date: Thu, 11 Apr 1996 07:58:42 +0100 (MET) From: "Hr Dr. S. Shapiro" Sender: toukie@zui.unizh.ch Reply-To: toukie@zui.unizh.ch Message-Id: <28722.toukie@zui.unizh.ch> To: chemistry@www.ccl.net Subject: Seeking examples .... Dear Colleagues; Suddenly and on very short notice I have been requested to make a "sales pitch" relating to the usefulness of receptor structures (as determined by X-ray crystallography or perhaps other means) _OR_ receptor models/theoreti- cal receptor structures (such as mini- or pseudoreceptor surrogates derived from QSAR data) vis-a'-vis drug design. I therefore request that anyone who can provide specific and concrete examples (including references to relevant publications and/or patents) of drugs and/or useful "biologicals" whose development was substantially facili- tated by knowledge of actual or postulated receptor structures to please for- ward that information to me as soon as possible. I shold point out that I am particularly interested here in antimicro- bial agents, but I would be grateful to receive information on _any_ sorts of drugs or "biologicals" whose development was substantially facilitated by knowledge of actual or postulated receptor structures. The structure of the target site for beta-lactam antibiotics such as the penicillins, cephalosporins, and cephamycins is well known. Are there any examples of new beta-lactams which have been designed on the basis of detail- ed knowledge of the target site? Likewise, are there any examples of clavu- lanic acids or other beta-lactamase inhibitors which were designed either in whole or in part on the basis of information regarding their binding to beta- lactamases? Again, references are important. Thanks in advance to all responders, from whom I hope to soon hear. Sincerely, S. Shapiro ZH toukie@zui.unizh.ch From thuber@Physik.TU-Muenchen.DE Thu Apr 11 05:46:01 1996 Received: from srv.cip.physik.tu-muenchen.de for thuber@Physik.TU-Muenchen.DE by www.ccl.net (8.7.1/950822.1) id FAA17260; Thu, 11 Apr 1996 05:12:39 -0400 (EDT) Received: from speedy.cip.physik.tu-muenchen.de by srv.cip.physik.tu-muenchen.de with SMTP id AA05776 for (5.67a/IDA-1.5/bs04); Thu, 11 Apr 1996 11:12:26 +0200 Received: by speedy.cip.physik.tu-muenchen.de (4.1/SMI-4.1) id AA28425; Thu, 11 Apr 96 11:12:25 +0200 Date: Thu, 11 Apr 1996 11:12:24 +0200 (MET DST) From: Thomas Huber To: chemistry@www.ccl.net Cc: Thomas Huber Subject: Looking for P6 benchmark Message-Id: Mime-Version: 1.0 Content-Type: TEXT/PLAIN; charset=US-ASCII Dear Computational Chemist! Are you interested in performing a real worlds application benchmark on YOUR brannew Pentium Pro machine? Yes? Do you have your P6 computer running under linux with >=16 MB ram and some spare MB on your hd? If not, forget all and read your next e-mail message! If yes, please contact me to receive a standard molecular dynamics benchmark to see the quantum leap of your machine compared to common supermarket personal computers! Please reply to thuber@physik.tu-muenchen.de Yours Thomas