From ccl@www.ccl.net Tue Oct 29 01:32:43 1996 Received: from bedrock.ccl.net for ccl@www.ccl.net by www.ccl.net (8.8.0/950822.1) id AAA25253; Tue, 29 Oct 1996 00:35:12 -0500 (EST) Received: from auric.chem.csiro.au for D.Winkler@chem.csiro.au by bedrock.ccl.net (8.8.0/950822.1) id AAA03078; Tue, 29 Oct 1996 00:35:09 -0500 (EST) From: Received: from [138.194.40.204] (mac-40204.chem.csiro.au) by auric.chem.csiro.au with SMTP id AA11369 (5.67b/IDA-1.5 for chemistry@ccl.net); Tue, 29 Oct 1996 16:31:17 +1100 Date: Tue, 29 Oct 1996 16:31:17 +1100 X-Sender: win097@auric.chem.csiro.au Message-Id: Mime-Version: 1.0 Content-Type: text/plain; charset="us-ascii" Apparently-To: Apparently-To: Apparently-To: Australian Science - Australia's Future Date: Tue, 29 Oct 1996 16:34:23 +1000 To: anchodd@postoffice.utas.edu.au, chminf-l@iubvm.ucs.indiana.edu, chemistry@ccl.net From: "Dr. Dave Winkler" Subject: Papers for RACI medicinal chemistry and pharmacology conference Please excuse cross postings. If anyone wants to register there is still time if they email me back in the next week or so or check URL for registration forms and first circular: http://www.chem.swin.edu.au/ma/mconf.html ROYAL AUSTRALIAN CHEMICAL INSTITUTE MEDICINAL & AGRICULTURAL DIVISION 13TH NATIONAL CONFERENCE "UP AND COMING RESEARCH IN AUSTRALIA" 8-11 DECEMBER, 1996, Monash University, Clayton 3168, Victoria, Australia Sunday 8 December ----------------- Research/Industry Interface Hands on Workshop Monday 9 December ----------------- New Paradigms in Drug Discovery (Chair: Prof Peter Andrews) Mark Gallop Combinatorial Chemistry: New Technologies for Drug Discovery Joe Maeji Parallel solid phase organic synthesis. Ron Quinn High throughput screening in natural product drug discovery New Directions in Drug Development (Chair: Prof. Graham Johnston) Nick Nicola Use of the CytoSensor to study cytokine signal transduction pathways Lew Defining the pharmacophore of omega conotoxin G6a - different results between biochemical and binding assays by alanine scan Paul Rolan Use of models and surrogates to expedite exploratory development. Leighton Medal Lecture (Prof. Graham Johnston) (Chair. Prof. Colin Raston) Workshop on Chemical Databases (Damon Ridley) Combined poster session. Tuesday 10 December ------------------- Biota Medal lecture Emerging disease threats (Chair: Dr. Andrea Robinson) Colin Masters Prions and dementia Seb Marcuccio Synthesis and Evaluation of Selected Acyclic Nucleoside Analogues as Antiviral Agents Colin Barrow Exploring the Chemical basis of Amyloid Formation in Alzheimer's Disease DNA and Cancer (Chair: Prof. Bob Brownlee) Bill Denny The Design of Tumour-Activated Prodrugs for Cancer Chemotherapy Venkataraman Novel Therapeutic Principal: Antisense Paradigm and Role of Computational Chemistry Marg't Harding Organometallic Anticancer Agents Sutherland A Combinatorial Approach to the Base Sequence Selectivity of DNA Binding Molecules McFadyen Prointercalators Based on the Co(III)/Co(II) Redox Couple as Potential Hypoxia-selective Cytotoxins 1400-1530 Agrochemistry (Chair: Dr. Kevin Winzenberg) Jim Peacock Gene shears and gene Technology in Agribusiness Max Tate Monitoring Vetch Toxins in Feed and Food (Keeping "Them" Honest) Delaere Needle in a Haystack. The Chemistry of in situ quantitation Whitelaw Solubilization of Inorganic Soil Phosphates by the Soil Fungus Penicillium radicm (sp. nov.) Parallels between agrochemical and drug discovery (Chair: Dr. Andy Liepa) George Fleet Sugar Mimics: From Hydantocidin to a new Class of Amino Acids Shiela Unkles The Potential of Biosynthetic Pathways as Targets for Novel Antifungal Agents Winzenberg Strategies for Discovering New Crop Protection Chemicals Johnson Use of Natural Products Sinharine and Strobilurin A, as Lead Structures for Crop Protection Chemicals Wednesday 11 December --------------------- Adrien Albert lecture - Dr. Keith Watson (Chair: Dr. Margaret Wong) Glycomimetic chemistry (Chair: Dr. Dave Winkler) George Fleet Sugar Mimics: Bicyclic and other Nitrogen Analogues of Sugars von Itzstein Synthesis of Functionalized Sialic Acids as Biological Probes Ooi An Investigation of Silaic Acid Lyase from E. coli Novel medicinal approaches (Chair: Dr. Tracy Nero) Dave Manallack Matrix Metalloproteinases in Inflammation Lia Addadi Protein Control Over Formation of Mineral Phases in Biomineralization Breuer A Peptidyl Prodrug of a Bisphosphonate for Improved Oral Absorption Coghlan Nitro Amino Acids as Masked Dehydroamino Acid Residues in Peptides McCluskey Novel Protein Phosphatase 1 and 2A Inhibitors: Analogues of Cantharidin Kuiper Molecular Modelling and Synthesis of Antifreeze Peptides Therapeutic leads from Natural Products (Chair: Dr. Seb Marcuccio) Roufogalis Development of Drug Leads from Plants Against Specific Biological Targets Paul Alewood Conatoxins as Molecular Templates for Drug Design Hood Preliminary Studies into a New Class of Non-nucleoside Inhibitors of Reverse Transcriptase Jones Host-Dependent and Independent Consituents of Mistletoes Learning and Cognition (Chair: Dr. Ted Lloyd) John Bremner Training of Medicinal Chemists: Opportunities to Lead Marg Wong A Year before The Mast: Developing Computational Chemistry Teaching Packages for use via the Internet Maddalena Prediction of Isoreceptor Binding Affinity with Neural Nets Soloviev Molecular Properties of a Unitary NMDA/Non-NMDA Glutamate Receptor Griffith What Makes a Ligand Selective for the Dopamine D4 Receptor Subtype? Jamie Design and Synthesis of Potent Inhibitors of Indoleamine 2, 3-Dioxygenase Cheers, Dave Dr. David A. Winkler Voice: 61-3-9542-2477 Principal Research Scientist Fax: 61-3-9543-8160 CSIRO Division of Chemicals and Polymers http://www.csiro.au Private Bag 10,Clayton South MDC, http://www.wark.csiro.au Clayton 3169, Australia From wwrich@ddix7.monsanto.com Tue Oct 29 09:32:57 1996 Received: from gatekeeper.monsanto.com for wwrich@ddix7.monsanto.com by www.ccl.net (8.8.0/950822.1) id JAA28490; Tue, 29 Oct 1996 09:25:49 -0500 (EST) Received: by gatekeeper.monsanto.com; id AA02250; Tue, 29 Oct 96 08:25:49 CST Received: from ddix7.monsanto.com(137.35.8.5) by gatekeeper.monsanto.com. via smap (V3.1.1) id xma002131; Tue, 29 Oct 96 08:25:38 -0600 Received: by ddix7.monsanto.com (940816.SGI.8.6.9/940406.SGI.AUTO) for CHEMISTRY@www.ccl.net id IAA06217; Tue, 29 Oct 1996 08:25:17 -0600 From: wwrich@ddix7.monsanto.com (Wendy W. Richardson) Message-Id: <199610291425.IAA06217@ddix7.monsanto.com> Subject: IRIX 6.2 and R10000 To: CHEMISTRY@www.ccl.net Date: Tue, 29 Oct 96 8:25:13 CST X-Mailer: ELM [version 2.3 PL12] We are about to upgrade one of our workstations to an R10000 processor, with the corresponding upgrade to IRIX 6.2. The guy from SGI said the 6.2 release was fairly stable, and the systems related stuff should all work fine, but we could have some problems with applications software (he is not familiar with modeling software). Has anyone else done this? Does your modeling software still work? Is it faster? Were there any special things you had to do to get things to work? Will I need to get/create another set of executables? I am most concerned about: Sybyl, Daylight, Gaussian94, Macromodel, Catalyst, Spartan I will summarize any responses I receive... ------------------------------------------------------------- ("`-/")_.-'"``-._ Wendy W. Richardson, Ph.D. (. . `) -._ )-;-,_() Sr. Research Investigator (v_,)' _ )`-.\ ``-' Searle _;- _,-_/ / ((,' 4901 Searle Parkway ((,.-' ((,/ Skokie, IL 60077 wwrich@ddix7.monsanto.com From ccl@www.ccl.net Tue Oct 29 23:17:29 1996 Received: from bedrock.ccl.net for ccl@www.ccl.net by www.ccl.net (8.8.2/950822.1) id XAA01738; Tue, 29 Oct 1996 23:00:10 -0500 (EST) Received: from pasteur.sc.ucl.ac.be for drossart@cico.ucl.ac.be by bedrock.ccl.net (8.8.2/950822.1) id XAA27046; Tue, 29 Oct 1996 23:00:08 -0500 (EST) Received: from drossart.cico.ucl.ac.be by pasteur.sc.ucl.ac.be (5.x/SMI-SVR4) id AA29089; Wed, 30 Oct 1996 05:01:41 +0100 Message-Id: <3276D24E.62A@cico.ucl.ac.be> Date: Wed, 30 Oct 1996 04:58:06 +0100 From: DROSSART Claude Reply-To: drossart@cico.ucl.ac.be Organization: U.C.L. - CICO - Chop X-Mailer: Mozilla 3.0 (Win95; I) Mime-Version: 1.0 To: anchodd@postoffice.utas.edu.au, chminf-l@iubvm.ucs.indiana.edu, chemistry@ccl.net Subject: ESOR VI Content-Type: multipart/mixed; boundary="------------29D4745625E4" This is a multi-part message in MIME format. --------------29D4745625E4 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit -- Avec les meilleurs sentiments de Claude Drossart, Universite catholique de Louvain-CICO-Chop 1, place Pasteur, 1348-Louvain la Neuve (Wallonie-Belgique) tel: 32-10-472714/ fax: 32-10-473074 --------------29D4745625E4 Content-Type: text/plain; charset=us-ascii; name="esor1cir.txt" Content-Transfer-Encoding: 7bit Content-Disposition: inline; filename="esor1cir.txt" Notes:- This message is being sent to multiple lists; my apologies if you receive it more than once. - We attach the greatest value to Exhibit and Sponsorship opportunities. ESOR-VI 6th European Symposium on Organic reactivity Louvain-la-Neuve 24 - 29 July 1997 _______________________________________First Circular The Catholic University of Louvain, located in the Belgian city of Louvain-la-Neuve, will host the next conference entitled "European Symposium on Organic Reactivity". This will be the sixth edition of a series of successful meetings held in Paris (1987), Padova (1989), Göteborg (1991), Newcastle-upon-Tyne (1993) and Santiago de Compostela (1995). The conference will be held during the period Thursday 24 to Tuesday 29 July 1997. The scientific sessions will start on Thursday afternoon and the meeting will end at lunchtime on Tuesday. Location ________ Louvain-la-Neuve is located about 30 km South of Brussels in the french-speaking part of Belgium. The city is connected with Brussels by rail and is readily accessible by road (Motorway E411) from everywhere in Europe. Brussels National Airport is linked to all major and most medium-size European cities. The Conference site will be part of the academic facilities of the Catholic University of Louvain (U.C.L.). This University was founded in the old Belgian city of Leuven in 1425 as one of the oldest universities in Europe. In the early 1970's, the french-speaking part of the University moved to a completely new city which was called Louvain-la-Neuve, on the territory of a town named Ottignies. The University population amounts to more than 20,000 students. Courses are organized in all disciplines of human knowledge by ten Faculties : Theology, Philosophy, Law, Economic and Social Sciences, Philology and Arts, Psychology and Educational Sciences, Sciences, Applied Sciences, Medicine and Agronomy. Scientific Programme ____________________ The meeting will be devoted to all aspects of physical organic chemistry. The conference programme will focus on three main topics : 1. Mechanisms and reactivity in organic, bioorganic and organometallic chemistry, including theoretical approaches 2. Photochemical and electron transfer activation processes 3. Molecular recognition and enzyme mechanism. The programme will include 12 plenary lectures, two parallel sessions with their own invited lectures. A limited number of oral presentations will be selected among the submitted contributions. Two separate poster sessions are planned on Friday afternoon and Monday afternoon with comfortable discussion times. Persons wishing to present an oral or poster contribution should submit a one-page abstract according to the format detailed below not later than February 15, 1997 and send it to Prof. M. Devillers ESOR-VI Conference Secretary Catholic University of Louvain Laboratory of Inorganic and Analytical Chemistry 1 place Louis Pasteur B-1348 Louvain-la-Neuve , Belgium Tel. : 32-10 47 28 27 Fax : 32-10 47 28 36 e-mail : devillers@inan.ucl.ac.be Plenary lectures ________________ Twelve recognized experts have already agreed to give Plenary Lectures on the following topics : V. Balzani,University of Bologna, Italy, Supramolecular photochemistry. S.J. Benkovic,The Pennsylvania State University, USA, Perspective on biocatalysis. F. Diederich,Swiss Federal Institute of Technology, Zurich, From supramolecular chemistry to medicinal chemistry. J.B. Engberts,University of Groningen, The Netherlands, Vesicles formed from synthetic amphiphiles. Fusogenic behavior and applications as drug carrier systems. J. Fréchet,Cornell University, USA, Designing for novel macromolecular architectures:from concept to applications. B.Giese,University of Basel, Switzerland, Reactivity of DNA radicals. Y. Kishi,Harvard University, USA, Synthetic studies in the field of natural product chemistry. H. Mayr,Technische Hochschule Darmstadt, Germany, Linear free enthalpy relationship : a powerful tool for the design of organic or organometallic syntheses. R. Noyori,Nagoya University, Japan, Asymmetric hydrogenation : mechanistic aspects. M. Poliakoff,University of Nottingham, U.K., Intermediates in organometallic chemistry. P. von Rague Schleyer,University of Erlangen-Nürnberg, Germany, Organic reactivity and computational chemistry. I. Willner,The Hebrew University of Jerusalem, Israel, Electroenzymes, photoenzymes and command surfaces - Tailored assemblies for optobioelectronic devices. Abstracts _________ Full one-page abstracts will be reproduced directly from authors'original documents. They should be typed or printed in English using double line spacing on A4 formatted white paper. The whole of the abstract must be contained within a rectangle of size 242 x 165 mm. It will be reduced to 79 %. The headings should be presented in the format given below, including the full line separating text and heading. References should be indicated within square brackets in the text and listed at the bottom of the abstract using standard Chemical Abstracts Source Service Index terminology followed by volume,(year within brackets) , first page. Example: DECOMPOSITION OF NITROSOUREAS IN THE PRESENCE OF DIFFERENT NUCLEOPHILES S. Amado*, A. Andrade, L. Garcia-Rio, J.R. Leis and A.M. Rios, Departamento de Quimica Fisica, Facultad de Quimica, Universidad de Santiago, 15706 Santiago de Compostela, Spain. The reactivity of different nucleophiles toward the ambident electrophile N-nitroso-N,N'-dimethylurea (NDMU) has been investigated. The experimental results... The Book of Abstracts including all lectures and oral or poster contributions will be handed out to all registered participants upon arrival. Social Events _____________ The provisional social programme for Conference participants includes the following events : Thursday : Welcome drink and get-together sandwich buffet at lunchtime Thursday evening : Concert Friday evening : Belgian Cheese and Beer party at the end of the poster session Sunday afternoon : Excursion Monday evening : Conference Dinner An Accompanying Persons' Programme will be arranged for the whole conference period. Further details will be included in the Second Circular. Registration fees _________________ -Normal pre-registration fee before March 31, 1997 BEF 10 000 Registration fee after March 31, 1997 BEF 12 500 -Students before March 31, 1997 BEF 5 000 after March 31, 1997 BEF 6 000 -Participants from Industry before March 31, 1997 BEF 15 000 after March 31, 1997 BEF 18 000 -Accompanying Persons BEF 2 000 Organizing Committees _____________________ Local Organizing committee -------------------------- Chairmen :Prof. J. Fastrez and Prof. L. Ghosez (U.C.L., Louvain-la-Neuve) Conference Secretary :Prof. M. Devillers (U.C.L., Louvain-la-Neuve) Members : Dr. O. B Nagy (U.C.L., Louvain-la-Neuve) Prof. P. De Clercq (R.U.G., Gent) Prof. F. De Schrijver (K.U.L., Leuven) Prof. L. Hevesi, (F.U.N.D.P., Namur) Prof. F. Kirsch-Demesmaeker (U.L.B., Brussels) Prof. A. Laschewsky (U.C.L., Louvain-la-Neuve) Prof. J. Marchand-Brynaert (U.C.L., Louvain-la-Neuve) Prof. J.-P. Soumillion (U.C.L., Louvain-la-Neuve) International Advisory Committee -------------------------------- Prof. P. Ahlberg (Chairman, Göteborg, Sweden) Dr. M. Eckert-Maksic (Zagreb, Croatia) Prof. J. Engberts (Groningen, Netherlands) Dr. R. Leis (Santiago de Compostela, Spain) Dr. H. Maskill (Newcastle-upon-Tyne, England) Prof. R. More O'Ferrall (Dublin, Ireland) Prof. P. Müller (Genève, Switzerland) Prof. M. Page (Huddersfield, England) Prof. Z. Rappoport (Jerusalem, Israel) Prof. M.-F. Ruasse (Paris, France) Prof. G. Scorrano (Padova, Italy) Prof. U. Siehl (Ulm, Germany) For further information, please refer to the Scientific Secretariat of the Conference : Prof. M. Devillers ESOR-VI Conference Secretary Catholic University of Louvain Laboratory of Inorganic and Analytical Chemistry 1 place Louis Pasteur B-1348 Louvain-la-Neuve , Belgium Tel. : 32-10 47 28 27 Fax : 32-10 47 28 36 e-mail : devillers@inan.ucl.ac.be or get a moment to see our page maintained by Claude Drossart at: http://www.chim.ucl.ac.be/CHIM/esor.html To receive the Second Circular/Application Form for this Symposium (January 1997), please print and fill in the following form, send it to the Conference Secretary ( or an Email with the same information). DO NOT SEND YOUR REPLY TO THE LIST ! _______________________________________________________________ Title : Prof. - Dr. - Mr. - Mrs. (circle when applicable) Name : ____________________________________________________________ First Name : ____________________________________________________________ Institution : ____________________________________________________________ Address : ____________________________________________________________ ____________________________________________________________ ____________________________________________________________ ____________________________________________________________ tel:_________________ fax:_____________________ e-mail:__________________________________________ I intend to present a short contribution preferably as oral presentation preferably as a poster I have no preference between oral and poster presentation --------------29D4745625E4--