From ccl@www.ccl.net Wed Nov 6 22:23:00 EST 1996
From: jkl@ccl.net
Date: Thu, 7 Nov 1996 14:19:03 +1100
Subject: 97.04.28 Solid And Solution Phase Combinatorial Synthesis
To: jkl@ccl.net
Solid And Solution Phase Combinatorial Synthesis
An In-Depth, Comparative Evaluation of Both Solid And Solution Phase Techniques
Small Molecule Synthesis Of Mixtures & Solid Compounds
Encoding & Deconvoluting & Screening Methods
Small Molecule Synthesis of Single Compounds
Compound Characterization & Analysis
Assaying Purity & Structural Identity
Automated Synthesis
Synthesis & Post-Synthesis Informatics
Automated Purification Methods
Reagent Preparation & Sample Processing
Sample Registration, Tracking & Structure Retrieval
April 28-29, 1997
The Crowne Plaza, New Orleans
New Orleans, LA
[Attend The Annual "Jazz in Heritage Festival", April 24-27 Register Early!]
Program
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Monday, April 28, 1997
7:45 Registration and Continental Breakfast
8:40 Chair's Opening Remarks
Applications Of Solid And Solution Phase Combinatorial Synthesis
In Drug Discovery
David M. Floyd, Ph.D.
Vice President of Discovery Chemistry
BRISTOL MYERS SQUIBB
SMALL MOLECULE SYNTHESIS Of MIXTURES
9:00 Heterocycles For Lead Generation
-Novel structural elements
-Variable ring size
-Variable flexibility
-Natural product-like with systematic synthesis
-Solid phase synthesis; automated
David Mendel, Ph.D.
Senior Organic Chemist
LILLY RESEARCH LABORATORIES
9:35 Solution Phase Combinatorial Chemistry: Discovery Of Linear And Cyclic
Polyamines With Potent Antibacterial Activity By Solution Phase
Simultaneous Addition Of Functionalities
-Isis has invented a unique combinatorial chemistry composed
of tertiary nitrogen and heterocyclic scaffolds
-Isis builds its libraries by a proprietary "solution phase,
simultaneous addition of functionalities (SPSAF)" approach
-Libraries generated are of low molecular weight, diverse,
information rich and present various levels of constraint
(linear, cyclic, spherical shapes)
-Versatile synthetic methodologies allow a variety of scaffolds
(footprints) to be rapidly prepared
-Extensive libraries from libraries methodologies have been developed
-Libraries can be rapidly prepared (less than 5 days) in
250-1000 mg. quantities
-Methodologies to selectively target RNA motifs with cationic,
constrained tertiary nitrogen scaffolds are in progress
-Libraries are single compounds from linear and cyclic tertiary
nitrogen scaffolds exhibit potent antibacterial activity
P. Dan Cook, Ph.D.
Vice President of Chemistry
ISIS PHARMACEUTICALS, INC.
10:10 Synthesis On Soluble Polymers: Liquid Phase Parallel Synthesis Of
Chemical Libraries
-The "Liquid Phase Parallel Synthesis" combines strategic features
of both solid phase synthesis and solution phase synthesis
-This method uses a supporting polymer (polyethylene glycol) that is
soluble in the reaction media and the polymer can be precipitated
selectively for isolation and purification purposes
-Excess reagents and byproducts were removed by simple filtration
-This technology allows reactions to be followed by NMR and TLC
-The use of PEG resin as a soluble support for the synthesis of small
organic molecules is demonstrated by the synthesis of several chemical
libraries
Soan Cheng, Ph.D.
Senior Research Chemist
COMBICHEM, INC.
10:45 Coffee & Tea
ENCODING & DECONVOLUTION METHODS
11:10 Encoded Combinatorial Library Directed Toward The Discovery Of Aspartyl
Protease Inhibitors
-Design, synthesis and encoding
-Screening against two aspartyl protease enzymes
-Decoding of active components
Theodore O. Johnson, Ph.D.
Research Scientist
PHARMACOPEIA, INC.
11:45 Synthesis And Deconvolution Methods For Mixture-Based Heterocyclic
Combinatorial Libraries
-The synthesis of many complex heterocycles has been achieved on
solid phase
-Synthesis of mixtures of these heterocycles by the "split and
recombine" method greatly enhances the efficiency of the organic
chemist
-Screening libraries of heterocycles as organized mixtures is very
efficient and does not necessitate a high-throughput assay
-Active compounds are identified by iterative deconvolution or
PositionalScan methods
Michael C. Griffith, Ph.D.
Senior Research Chemist
HOUGHTON PHARMACEUTICALS, INC.
12:20 Luncheon For Speakers And Attendees
1:50 Radiofrequency Encoding As A Tool In The Synthesis Of Organic
Compound Libraries: Combining The Advantages Of Parallel And
Split-Pool Synthesis
-Radiofrequency memory chip technology
-Encoding orthogonal to chemical synthesis
-Synthesis of 102-104 discrete compounds in 5-10 mg amounts
-Automated microreactor handling using the AccusortTM split approach
A. W. Czarnik, Ph.D.
Senior Director, Chemistry
IRORI QUANTUM MICROCHEMISTRY
2:25 Adventures In Screening: To Mix Or Not To Mix...Strategies And
Experiences
-Making and screening mixtures from single compound libraries
-Synthesising non-encoded combinatorial mixtures for lead discovery
-Deconvolution strategies
-Single compound combinatorial synthesis for lead optimization
Alex Harris, Ph.D.
Director, Biochemical Pharmacology
CHIRON CORPORATION
SMALL MOLECULE SYNTHESIS Of SINGLE COMPOUNDS
3:00 Manual And Automated Parallel Synthesis Of Individual Compounds At
Affymax
-Manual and automated parallel synthesis
-Application for chemical library development
-Drug discovery
-Development of instrumentation for parallel synthesis
Valery Antonenko, Ph.D.
Senior Scientist and Group Leader, High-Throughput Parallel Organic
Synthesis
AFFYMAX RESEARCH INSTITUTE
3:35 Coffee & Tea
3:55 Structure-Directed Parallel Unit Synthesis For Lead Generation &
Optimization
Joseph C. Hogan, Ph.D.
Chairman and Chief Scientific Officer
ARQULE, INC.
METHODS FOR COMPOUND CHARACTERIZATION & ANALYSIS
4:30 A Fully Automated Mass Spectrometry-Based System For The Rapid Analysis
And Purification Of Combinatorial Libraries
-Fast HPLC/MS analyses achieved in 5 minutes
-Comparative performance of chromatographic supports for compound
separations
-Fully automated purity assessment (UV and TIC) and data processing
using AppleScriptsTM
-Purification based on "one-sample-one-tube" format, using mass
spectrometer and AppleScriptingTM to trigger fraction collection
-Unattended "batch" purifications (i.e. 50 samples/instrument/night)
at 10-50mg level
Daniel B. Kassel, Ph.D.
Director, Analytical Chemistry
COMBICHEM, INC.
5:05 Chair's Closing Remarks Followed by Wine & Cheese Reception
7:30 Join your colleagues at New Orleans famous Antoine's for dinner tonight!
The meal affords a great opportunity to unwind in a casual atmosphere
after the first day's presentations and get to better know your fellow
attendees. Three courses will be offered and four wines tasted. Price
per person is $65, all inclusive. Transportation will be provided to
and from the Restaurant. Please check the box on the back page
registration form if you would like to join us!
Tuesday, April 29, 1997
7:45 Continental Breakfast
8:30 Chairs's Recap Of Day One
David M. Floyd, Ph.D.
BRISTOL-MYERS SQUIBB PRI
METHODS FOR COMPOUND CHARACTERIZATION & ANALYSIS (Continued)
8:40 Useful Methods To Monitor Solid Phase Reactions
-Examples of common "wet chemical" tools
-Analysis after cleavage from resin: pros and cons
-Spectroscopic methods applied to compounds still attached to resin
with a focus on IR and NMR
-Examples and case histories of reaction monitoring
James R. Wareing, Ph.D.
Senior Fellow and Head of Combinatorial Chemistry
SANDOZ, INC.
9:15 Applications Of Capillary Electrophoresis To The Analysis Of
Combinatorial Mixtures
-Capillary Electrophoresis
-Affinity capillary electrophoresis coupled to mass spectrometry
-Electrospray ionization mass spectrometry
-HPLC mass spectrometry
-High resolution mass spectrometry
Paul Vouros, Ph.D.
Bradstreet Professor of Chemistry
NORTHEASTERN UNIVERSITY
9:50 The Use Of Evaporative Light Scattering In Quality Control Of
Combinatorial Libraries
Cheryl Garr, Ph.D.
Project Manager, Synthetic and Combinatorial Chemistry
PANLABS, Inc.
10:25 Coffee & Tea
AUTOMATION
10:45 Applications Of Automated Synthesis In Combinatorial Chemistry
-Strategies for automated combinatorial chemistry
-Automation of reagent delivery
-Automated workstation approach to synthesis
-Development and integration of automated quality control
-Data management and compound tracking
Martin A. Murphy, Ph.D.
Research Scientist III
AMGEN, INC.
11:20 Automated Technologies For The Handling And Preparation Of Reagents
And Formulation Reactants For Combinatorial Synthesis
-Setup and labeling of storage containers
-Reagent preparation and formulation
-Inert storage and container handling
-Liquid transfer techniques of reagents and reactants
-Data management and spatial address in an automated system
Brian Lightbody
Vice President Drug Discovery Business Development
ZYMARK CORPORATION
12:00 Luncheon For Speakers And Attendees
AUTOMATION (Continued)
1:20 New Approaches For Solid And Liquid Material Handling At Glaxo-Wellcome
-Customizing solid sample handling
-Automating liquid handling
-Barcoding
-Solid and liquid inventory systems
-Liquid storage
-Future enhancements
Brenda Johnson Ray
Supervisor of Chemical Information Services
GLAXO WELLCOME, INC.
SYNTHESIS & POST-SYNTHESIS INFORMATICS
1:55 Computational Adventures In The Experimental World: Pre- And
Post-Synthesis Instrument Interface
Edward P. Jaeger, Ph.D.
Senior Director
3-DIMENSIONAL PHARMACEUTICALS, INC.
2:30 Information Management And Combinatorial Chemistry: Reagent Tracking,
Sample Registration And Structure Retrieval
Maurizio Bronzetti, Ph.D.
Senior Scientist, Chemistry Solutions
MDL INFORMATION SYSTEMS, INC.
AUTOMATED PURIFICATION METHODS
3:05 Preparative HPLC In Automated Synthesis
-Rapid high-throughput preparative liquid chromatography
-Column dimensions and particle size to optimize rapid analysis without
loss of resolution
-Autoinjection and multiple collectors for queuing capabilities
-User-friendly interface to widen the user base
Marion G. Young, Ph.D.
Senior Research Scientist
BRISTOL-MYERS SQUIBB PRI
3:40 Automated Parallel Purification Methods
The generation of high quality products from combinatorial chemistry
programs requires high-throughput methods for post-synthetic operations
including workup, isolation, purification, and analysis. The following
tools have been integrated in our laboratories to provide methods for
workup, isolation, and purification:
-Parallel processing
-Robotic automation
-Phase separation technology for liquid-liquid extraction
-Solid phase extraction for product purification
Sheila H. DeWitt, Ph.D.
Vice President, Technical Development
DIVERSOMERR TECHNOLOGIES, INC. & PARKE-DAVIS PHARMACEUTICAL
RESEARCH
4:15 Chair's Closing Remarks
WHO SHOULD ATTEND
Pharmaceutical, Biotech and Academic Research Chemists:
-Medicinal Chemists
-Organic Chemists
-Synthetic Chemists
-Structural Chemists
-Licensing
PAYMENTS: The conference registration fee is $995. This includes all
breakfasts, lunches, refreshments, receptions and the conference
documentation workbook. Payments may be made by company check,
American Express, Visa, MasterCard or Diner's Club. Please make checks
payable to Strategic Research Institute, L.P. and be sure to write the
registrant's name on the face of the check along with the conference
code CS110. PAYMENTS MUST BE RECEIVED TEN (10) BUSINESS DAYS PRIOR TO
THE CONFERENCE.
Discounts:
Advance Registration Drawing: Register by February 3 and your name will be
entered into a drawing for a complementary pass to attend the Conference
Academic Discount: The conference registration fee for full-time academic
and government is $695
Poster Session We encourage attendees to display scientific work during
the conference; please contact Mark Alexay at 800-599-4950, extention 251.
Poster board dimensions are 6' X 4'. Registration fees are as stipulated
above. You may submit an abstract for inclusion in the documentation book
until April 1, 1997. The session will be limited to 10 posters.
Hotel Accommodations: We have reserved a limited block of rooms with the
hotel at a special discounted rate for our attendees. To secure your
accommodations, please contact the hotel at least four weeks in advance
and specify that you are a Strategic Research Institute conference
attendee. The "rack" room rate at the Crown Plaza during the "Jazz
In Heritage Festival" is $226.95. The SRI discounted rate is $135.
PLEASE BOOK YOUR ROOM BEFORE FEBRUARY 28 TO BE ASSURED OF ROOM AVAILABILITY
AT THIS RATE
Venue:
The Crowne Plaza, New Orleans
333 Powdras St.
New Orleans, LA 70130
ph: 504-525-9444
fax: 504-581-7179
Travel Discounts: To take advantage of preferred airfares, please call the
Business Travel Buying Group reservations center at 1-800-327-8728 and
identify yourself as a Strategic Research Institute attendee/speaker.
Cancellations: All cancellations will be subject to a $227 administration fee.
n order to receive a prompt refund, your notice of cancellation must be
received in writing (by letter or fax) five (5) business days prior to the
conference. We regret refunds will not be issued after this date. The
registration may be transferred to you or another member of your organization
for any Strategic Research Institute conference during the next twelve months.
If you plan to send a substitute in your place, please notify us as soon as
possible so that materials and preparations can be made.
In the event of a conference cancellation, Strategic Research Institute
assumes no liability for non-refundable transportation costs, hotel
accommodations or additional costs incurred by registrants.
Dear Colleague:
I hope you will be able to join us for an exciting and informative conference
on Solid & Solution Phase Combinatorial Synthesis in New Orleans, LA
on April 28-29, 1997.
This is a "nuts & bolts", interdisciplinary meeting organized to provide
the pharmaceutical chemist an in-depth analysis of both solid and solution
phase methods and techniques for the synthesis, analysis and evaluation of
combinatorial libraries. The conference is designed to enable you to do
a side-by-side comparison of a variety of combinatorial techniques currently
utlized for drug discovery and to explore some of the emerging techniques in
this rapidly evolving field.
Each section is carefully designed to take you through the steps involved
in automated high-throughput synthesis and to highlight the challenges
that are yet to be overcome. The meeting is set up to maximize your
opportunity to compare and contrast the relative merits of the available
methods in terms of your own research needs.
Some of the highlights include:
-Small Molecule Synthesis of Mixtures
-Encoding and Deconvolution Methods
-Small Molecule Synthesis of Single Compounds
-Methods for Compound Characterization And Analysis
-Automation
-Synthesis And Post-Synthesis Informatics
-Automated Purification Methods
You are also cordially invited to attend the optional wine-tasting dinner
at New Orleans famous Antoine's Restaurant on April 28 after the first
day's presentations. The dinner is organized to promote greater after
hours social interaction among participants in a casual atmosphere - it
should be a lot of fun! Please register by March 21 as the private
dining room will have limited capacity.
To reserve your place at the conference, please complete the registration
form on the back of the brochure and fax it to the sponsor, Strategic
Research Institute, at 212-302-9850. You may also register by phone
at 800-599-4950 (212-302-1800 outside the USA), by E-mail at
info@srinstitute.com or send the form to: SRI, 500 Fifth Ave., 11th floor,
New York, NY. 10110.
I look forward to meeting you, or seeing you again, on April 28.
Sincerely,
David M. Floyd, Ph.D.
Vice President of Discovery Chemistry
Bristol-Myers Squibb PRI
Conference Chairman
David M. Floyd, Ph.D.
Bristol-Myers Squibb PRI
Conference Faculty
Daniel B. Kassel, Ph.D.
CombiChem, Inc.
David Mendel, Ph.D.
Lilly Research Laboratories
Joseph C. Hogan, Jr.
ArQule, Inc.
Valery Antonenko, Ph.D.
Affymax Research Institute
Theodore O. Johnson, Ph.D.
Pharmacopeia, Inc.
Marian G. Young, Ph.D.
Bristol-Myers Squibb PRI
Cheryl Garr, Ph.D.
Panlabs, Inc.
A. W. Czarnik, Ph.D.
IRORI Quantum Microchemistry
Sheila H. DeWitt, Ph.D.
DIVERSOMERR & Parke-Davis Pharmaceutical Research
Martin A. Murphy, Ph.D.
Amgen, Inc.
Alex Harris, Ph.D.
Chiron Corporation
Brian G. Lightbody
Zymark Corporation
Brenda Johnson Ray
Glaxo Wellcome, Inc.
Edward P. Jaeger, Ph.D.
3-Dimensional Pharmaceuticals, Inc.
Paul Vouros, Ph.D.
Northeastern University
James Wareing, Ph.D.
Sandoz
Maurizio Bronzetti, Ph.D.
MDL Information Systems, Inc.
Michael C. Griffith, Ph.D.
Houghton Pharmaceuticals, Inc.
P. Dan Cook, Ph.D.
Isis Pharmaceuticals, Inc.
Soan Cheng, Ph.D.
CombiChem, Inc.
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